Introduction
Biochemize S.L. is a biotechnological company focused in the
design and development of processes based on biocatalysis.
Our technological platform lies in the use of enzymes or
microorganisms to perform chemical reactions able to substitute
manufacturing processes based on classical organic chemistry.
Location
We are located in Terrassa, at 20 km from Barcelona.
Our office and laboratories are part of the facilities of the Technology
Centre of our associate partner Leitat.
Our Technology
Biochemize S.L. develops bioprocesses using biocatalysts (enzymes or
microorganisms) in single or multiple transformation steps.
Our technological platform P2B (Platform to Biochemize) is capable to
perform high throughput screening of biocatalysts, reaction conditions,
suitable substrates and products obtained.
The screening can be done in a short period of time and renders
information about different possible bioprocesses and conditions that could
be further developed at a larger scale.
P2B – Platform To Biochemize
P2B is the key to determine quickly with low risk and at very small scale
if a conceptual biotransformation is technologically viable.
Once the succeeding biocatalysts or bioprocesses have been identified,
Biochemize S.L. investigates at lab scale the experimental conditions
which can lead to the highest yields.
Two approaches can be followed:
P2B Bioprocess
Development of bioprocesses suitable to substitute
established synthetic procedures up to an industrial scale
already
P2B Discovery
Perform biotransformations that can lead to a (new) chemical entity
with improved features compared to the starting molecule
P2B – Discovery
P2B Discovery is an ideal approach for molecules with a complex structure
or different functional groups that can be affected when trying to modify
them by synthetic procedures.
Biocatalysts can be used to obtain new lead, lead optimization, me-too and
me-better compounds by modification of already available structures.
P2B – Discovery
The biotransformation can be:
Directed
The type of transformation is selected based on the functional group or
structure targeted.
This approach is suitable when it is well known what feature is
conferred by the new functional group or structure in the final molecule
(e.g. make it more soluble)
Exploratory
The transformations applicable are diverse in order
To test what kind of molecules can be obtained from
a given starting structure or what kind of final properties may be achieved.
This approach is appropriate to seek new development opportunities
(e.g. improved or different pharmacological properties)
P2B – Discovery Biotransformations
Oxidations / Reductions
Hydration / Dehydration
Glycosilations
Sulfidations / Sulfoxidations
Aromatic Chlorination
N-, O-, S-methylation
Nitrilation
Alkylation / Dealkylation
Amide and Ester formation / hydrolysis
Potentially, any biotransformation already described…
Applications of P2B – Discovery
Evaluation of pharmacological properties
Improve the solubility
Source of building blocks
Obtain more stable molecules
Increase the IP of the company or the pipeline of products
Support in Analytical Methods development
More…
Project Management in P2B – Discovery
The P2B Discovery process consists of the following phases:
Bibliography
Assessment
PHASE I
Biotransform.
Screening
Biocatalyst
Selection &
Reproduction
Compound
Characteriz.
PHASE II
PHASE III
PHASE IV
Small Scale
Production
Tests of
Properties
by Customer
PHASE V
 Flexible: Phases can be omitted, merged, delimited or adapted to each project or
customer requirements.
 Step-wise: Each phase is not planned nor quoted until the previous phase is
completed and the results presented.
 Risk-Control: The customer decides the project continuation at each phase
depending on results and conclusions obtained so far.
 Fast: The objective is to provide small amounts of promising (new) molecules in a
short time, avoiding setting-up long, difficult and low yield synthetic procedures.
 Results oriented: The customer is able to decide if full development is a business
opportunity according to the properties tests of molecules provided.
Operations
Biochemize S.L. offers the most outstanding and up to date technology
options, while maintaining an industrial scope.
If necessary, many operations can be outsourced to other companies and
research centres under our direction and supervision.
We have a powerful network of contacts in biocatalysis and
bioprocessing. Several partnership agreements have been established.
Advisors
Analytical Services
Biocatalyst Suppliers
Bioprocessing Services
Biotransformation Experts
Enzyme Screening
Enzyme Immobilization
Genetic Engineering
Manufacturers
Research & Development
Scaling-Up Services
Austria
Bulgaria
China
Denmark
Ireland
Italy
Korea
Netherlands
Spain
United Kingdom
United States
Why contracting Biochemize?
We offer the most outstanding and up to date technology options.
Industrial scope guaranteed: productivity, costs and risks are the key
drivers of our evaluations.
Our technology platform (P2B) is a powerful tool for fast, low risk and
small scale proof of concept verifications.
We increase the success possibilities through the P2B platform and our
network of contacts.
Project management based on a development by phases approach.
The customer controls the risks and costs associated to the project
development.
Contact
Jaume Mir
Founder
CEO and Commercial Director
E-mail:
jmir@biochemize.com
Telephone:
++34 686 441 120
Address:
C/. de la Innovació, 2
(Leitat Centre Tecnològic)
88225 – Terrassa
(Barcelona) SPAIN