Separating a Synthetic
Pain Relief Mixture
What is the mass percent of pain reliever in
your mixture?
Methods of Separation
• Filtration, evaporation,
crystallization, distillation,
extraction
What is extraction?
Based on immiscible (liquidliquid) substances
Use about
50 mL ethyl
acetate and
let sit for 57 minutes.
How to use separatory funnel
1. Close stop cock to ensure liquid will
not spill.
2. Hold stopper when inverting the
funnel to avoid having the stopper
fall out when funnel is upside down.
3. Open stopcock to VENT excess
pressure.
4. Repeat the shaking/venting process
to ensure equilibrium distribution
of the organic solute between the
desired layers.
Reaction of Acid and Base
Reaction of Acid and Base
+ NaOH  salt and water
COONa
Salt
+ H2O
Reaction of Acid and Base
+ NaOH  salt and water
+ H2O
NaO
Salt
Reaction of Acid and Base