Diseases of the Eye CC

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Diseases of the Eye

Casey Conway

Jeannie Stall , R.V.T. & ???

Credits : Clip Art graphics/Google images

The Eye

• CDCA has great picture of a cross section.(hint)

• Most highly developed of all senses

• Most pets can live quality lives with a vision loss

• Proper diagnosis, quick treatment – Essential!

• 3 main categories of eye diseases:

▫ Accessory structures

▫ The globe

▫ The retina and the neural pathways

Anatomy Credits: ukvetsonline

Diseases of the Accessory

Structures

• Eyelids, conjunctiva, tear ducts, third eyelid, lacrimal glands

• Red eyes, blepharospasm (squinting), ocular discharge

• Common causes: Trauma & infection

• Conjunctivitis/Epiphora(overflow of tears)/

KCS (Keratoconjunctivitis sicca)/Cherry Eye

Conjunctivitis

• Inflammation of the conjunctiva

• Rarely a primary dz process

• Canine: can be non-infectious or infectious

Feline : is primarily infectious

▫ FHV – seen w/ Upper Resp. Tract symptoms

▫ Calicivirus

Chlamydia psittaci

▫ Mycoplasmas

Conjunctivitis cont’d

• Clinical signs

▫ Chemosis (swelling)

▫ Hyperemia (redness)

▫ Ocular discharge

▫ +/- signs of URT dz

• Dx

▫ PE (thorough exam of conjunctiva/foreign body)

▫ Schirmer Tear Test, conj. scraping (cytology, c & s)

• Tx:

▫ Resolve underlying systemic dz.

▫ Topical antibiotic ointments/drops

▫ Nonsteroidal oint/drops may be needed

▫ Keep eyes clean and clear

• Prevent eye issues – riding out car window!

Epiphora

• Overflow of tears

▫ Overproduction (pain or irritation)

▫ Faulty drainage: (lacrimal duct blocked by swelling or trauma)

• Clinical Signs

▫ Watering of the eye

▫ Wet facial hair

▫ Secondary bacterial infection of facial skin

▫ Discoloration of the facial hair

Epiphora cont’d…….

• Dx:

▫ Eye exam

▫ Fluorescein dye

▫ Dacryocystorhinography ( Radiography of nasolacrimal duct )

• Tx:

Resolve primary cause of pain & irritation /

Flush lacrimal ducts / Surgery / Topical abx/ Trim hairs

Eyelid Diseases

• At the base of each eyelash is a sebaceous gland

Hordeolum: Meibomian gland abscess, usually caused by a staph. infection

Chalazion: When inflammation involves meibomian glands & granulation occurs

• Eyelid neoplasms : Older animals/ most are benign (cat usually malignant),

Squamous cell carcinoma most common tumor

Blepharitis:

Swelling of the eyelids

• Causes:

▫ Allergens

▫ Nutritional Deficiencies

▫ Viral

▫ Dermatitis from any cause

• Clinical signs

▫ Generalized swelling of lid

▫ Periocular pruritis (itchy eyes)

▫ Periocular alopecia ( hairloss)

▫ Rubbing of the eyes

Blepharitis Cont.

• Dx:

▫ Eye exam

▫ Skin scrape

▫ Fungal culture

▫ Bacterial cultures

• Tx: warm compresses

▫ Express hordeolum (staph infection)

▫ Surg. r emoval of chalazion (granulation tissue)

▫ Topical abx or systemic abx

▫ Corticosteroids ( Prednisolone)

▫ Antifungals ( Conofite or Tresaderm)

Blepharitis

Entropion

• Eyelids roll in against the cornea

• Common in dogs, not in cats

• 3 main forms:

▫ Congenital: breeds have large orbits with deep-set eyes, inadequate lid support, lid droops over the lower orbital rim and inverts – Collies, Great Danes, Irish

Setters, Dobes, Goldens, Rotts, Weim (primary lid deformities, poor ocular muscle development)

▫ Acquired nonspastic: surgical or traumatic – scarring of the lid with contraction – lid turns inward

▫ Acquired spastic – most common in cats – secondary to painful corneal lesions, conj. inflam. or both

Entropion

Entropion

• Clinical Signs

▫ Rolling inward of the lid margin(s)

▫ Epiphora (tear overflow)

▫ Chemosis ( conjunctiva swelling )

▫ Swelling

▫ Conjunctivitis

▫ Blepharospasm(eyelid muscle spasm)

▫ Pain

▫ +/- corneal ulceration

▫ Photophobia

Entropion Con’t……

• Dx:

▫ Observe lids interaction with globe

▫ Eye exam while awake

• Tx: Surgical correction

Ectropion:

Eyelids that roll outward, exposing the cornea

• Excessive lid droops outward

• Natural breed characteristic for:

Basset hounds, bloodhounds, cocker span, clumber span,

Eng. bulldogs, St. Bernards – usually asymptomatic

• All breeds: Secondary to muscular dz in senile dogs/

Dogs w/ surgical overcorrection of entropion

• Clinical signs

▫ Lid eversion

▫ Conjunctivitis

▫ Epiphora

▫ Keratitis

▫ Purulent exudate

Ectropion Cont.

• Dx:

▫ Observe lids

▫ Interaction with globe

▫ Eye exam while awake

• Tx: Surgical correction advised if clinical signs present

“Cherry Eye” or

Hypertrophy of Nictitans Gland

• Third eyelid:

▫ Protective structure/Spreads pre-corneal tear film

Covers eye to protect from injury/ Produces ~50% of lacrimal fluid

• Prolapse of 3 rd eyelid/gland: “passive forward displacement when eye withdrawn into orbit”

Hypertrophy of gland ONLY occurs in K9’s

• Etiology: Unknown cause

• Breeds: Basset, beagle, Boston, cocker

Cherry Eye

• Usually seen in young dogs (< 2 yrs. old)

-usually neoplasia if seen in old K9’s & cats

• Medial canthus is filled with red, swollen, third eyelid, resembles a small cherry

• Clinical signs

▫ Reddened enlargement of tissue in the medial canthus of the eye

▫ Mild irritation

▫ Usually no pain

▫ Epiphora ( tears)

▫ +/- conj. irritation

Cherry Eye continued…..

• Dx:

▫ Clinical signs

▫ Predisposed breed

▫ Rule out tumor (usually older dogs & cats)

• Tx:

▫ Surgical replacement of the gland, Tuck sutured

Avoid excision – predisposes to KCS

– only excise in cases of neoplasia

• W/O sx., corneal damage can occur & may affect vision

Cherry Eye

Glaucoma:

• In healthy eye:

Aqueous fluid production =‘s aq. fluid amt. leaving eye, so IOP(intraocular pressure) remains fairly constant

• More aqueous fluid produced than leaves = glaucoma

• Normal k9/fel IOP range: 12-22 mm Hg w/ Tono-pen

• Most K9’s have decreased outflow, not increased prod.

• Primary – inherited defect (cocker, basset, chow)

• Secondary –drainage angle obstruction secondary to another dz.– ie: Neoplasia, uveitis, lens luxation, hemorrhage

Glaucoma cont’d

Acute – elevated IOP (> 60 mm Hg ) can produce blindness within hours

Clin. signs: Ocular pain, vascular congestion, diffuse corneal edema, dilated pupil, sluggish or unresp to light,

+/- blind

Chronic – painful, blind eye which is unresponsive to med. therapy. Make pet comfy w/salvage procedures

Clin. Signs: Enlarged lobe, corneal striae, optic disk cupping, pain, blindness

• Dx: IOP > 30 mm Hg,/ clin. signs/ r/o luxated lens

• Tx: Acute – true emergency – decrease IOP rapidly, sx

Chronic – sx – enucleation

• Bilateral disease – even if one eye is asymptomatic

Corneal Ulcers

Ulcerative Keratitis

• Cornea:Window of the eye- has 4 layers

▫ Epithelium

▫ Stroma

▫ Descemet’s membrane

▫ Endothelium

• Full-thickness loss of corneal epithelium exposing stroma

• Etiology: Trauma, chemicals, foreign body, prev. dz. ie:

KCS/ Herpes in cats, conformation issues, distichiasis (tiny, inwardly –facing meibomian gland hairs)

• Clinical signs

▫ Pain

▫ Epiphora

▫ Blepharospasm

▫ Conjunctival hyperemia

Corneal Ulcers

• Dx:

▫ Fluorescein dye- absorbed by stroma, not by epithelium (green uptake of dye)

WARN client about fluorescent green dye !!

• Tx:

▫ Topical Atropine

▫ Topical abx

▫ Sx

• Meds. w/ cortisone slow healing & makes condition worse

• Frequent re-evaluations needed to monitor progress/healing

Pannus:

Chronic Superficial Keratitis

• Superficial corneal vascularization & infiltration of granulation tissue (lymphocytes & plasma cells)

• Progressive, bilateral, degenerative, can result in blindness

• Cause – immune-mediated, animals at > 5000 ft most susceptible (G.shep, B. Terv, B. Collie, Greyh, SibHusky)

• C/S: breed predisposed with opaque lesion – pink or tan

• Dx: corneal scraping – infiltrate, eye exam

• Tx: Antiinflam. for life of patient, +/- subconj. inj., cryosurgery, superficial keratectomy

• No cure

Treatment to maintain regression of lesion is life-long

Pannus

“KCS”:

Keratoconjunctivitis Sicca

• Loss of both lacrimal glands

• Viral inf., drug-related toxicities, Imm-mediated dz, inflamm, breed predisp., congenital abn

• Most cases idiopathic, older >7 yr. – neutered

• Clinical signs

▫ Recurrent conjunctivitis

▫ Corneal ulcers

▫ Keratitis

▫ Cornea & conj. appear dull, dry, & irregular

▫ Ocular discharge

▫ Blepharospasm

▫ Crusty nares

KCS cont’d …..

• Dx:

▫ Schirmer Tear Test <15mm/min on repeat testing (k9 15-

25, fel 11-23) NOTE: Perform this test 1st

▫ 2 nd : Fluorescein dye –assess ulcer presence

• Tx:

▫ Stimulate tear prod. w/meds (cyclosporine)

▫ Topical art. tears

▫ Surgery if medical tx are unsuccessful

(parotid duct transposition)

• Failure to treat will result in blindness

Cataracts :

• Most common dz. involving the lens

• An opacity of the lens sufficient enough to cause a reduction in visual function – aging cells w/in lens become dehydrated & overlap each other, producing a central change in the reflection of light- lens may appear grey and opaque

• Freq. cause of blindness in dog, occas. seen in cat

• Etiology: Inherited, secondary to diabetes mel., hypocalcemia, trauma, nutritional deficiency, electric shock, uveitis, or lens luxation

(Photo Credits: dog-health-handbook.com )

Cataracts cont’d

• Clinical signs

▫ Progressive loss of vision

▫ Opaque pupillary opening

▫ Signs related to systemic dz. (diabetes mellitus or hypocalcemia)

• Dx:

▫ Complete eye exam/Assess via obstacle course/

Lack of menace /Failure to track visual responses

Photo Credits: petdig.com

Cataracts cont’d……..

• Pupillary light response is usually normal

• Tx:

▫ Sx removal

▫ Tx of any other dz

Anterior Uveitis

• Inflammation of the uvea (iris, ciliary body, choriod)

• Trauma, extension of local infx, foreign body, neoplasm, thermal trauma, parasites, protozoa

(bact, viral, mycotic dz – hematogenous spread)

• C/S: epiphora, photophobia, blepharospasm, +/vision defects, corneal edema, chemosis, prolapsed

3rd eyelid, pain, change in iris color

• Dx: c/s, hx, labs, x-ray, ultrasound, tonometry

• Tx: I.D. & elim. cause, control inflamm w/topical steroids (w/o tx, vision will eventually be lost)

Progressive Retinal Atrophy

• Group of hereditary retinal disorders seen in many breeds of dogs

(can occur in cats, but not as frequently)

• Toy poodles, min poodles, goldens, Irish sett, cockers, min sch, collies, samoyed, gordon sett,

Norw. Elkhound

• C/S: defective night vision, slowly progressive loss of day vision, cataract formation

• Dx: labs, eye exam of retina

• No Tx. currently exists

Horses

• Entropion

• Conjunctivitis – Summer/ dry, dusty condition /flies

• Corneal ulcers

• Cataracts – Sx. prognosis is good in foals

• Many blind horses can still be ridden safely, if owner doesn’t exceed horse’s ability & comfort level … (or the owner’s !)

“Moon Blindness”

Periodic Opthalmia, Recurrent Uveitis

• Comes & goes/ exact cause undetermined

• Many animals have high Lepto antibody titer

• Signs: cloudy eye, blepharospasm, excessive tears

• Dx: visualization of protein flare in fluid of anterior chamber, affected eye may be smaller, corneal stain, Lepto titer

• Tx: topical corticosteroids, atropine, banamine or Subconjunctival long-acting steroid injections

Sheep and Goats

Entropion – most common ocular abnormality in neonatal lambs

Infectious Conjunctivitis (Pinkeye) – responds well to medication – herd management

Cataracts – most common lens abnormality in sheep and goats

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