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krok 1 2021 13 may solution with highlights

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1. A patient suffering from gout Was prescribed allopurinol. What pharmacological
property of allopurinol provides therapeutic effect in this case?
A. Competitive inhibition of xanthine oxidase
B. Acceleration of nitrogen-containing substances excretion
C. Acceleration of nucleic acids synthesis
D. Deceleration of pyrimidine nucleotides salvage
E. Acceleration of pyrimidine nucleotides catabolism
2. Autopsy of the body of a 9-year-old child shows numerous irregular defects of varying
depth with uneven margins and gray-white films tightly attached to the underlying tissue
on the rectal mucosa. What disease can be suspected?
A. Salmonellosis
B. Amebiasis
C. Dysentery
D. Typhoid fever
E. Cholera
An infant, who was on synthetic formula feeding, developed signs of vitamin B1
deficiency. What reactions docs this vitamin take part in?
A. Proline hydroxylation
B. Redox reactions
C. Keto acids oxidative decarboxylation
D, Amino acids transamination
X. Amino acids decarboxylation
A 43-year-old patient suffers from acute Pancreatitis with disturbed common bile duct
patency. What condition can develop in this case?
A. Hepatic coma
B. Mechanical jaundice
C. Portal hypertension
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D. Parenchymal jaundice
E. Hemolytic jaundice
the first-aid center has received a victim of a traffic accident diagnosed with closed
displaced fracture of the middle third of the thigh. For repositioning of bone fragments
the patient received 10 Ml of 2% dithylinum solution intravenously, which resulted in
prolonged period of apnea and muscle relaxation. What enzyme is deficient, resulting in
such pharmacogenetic enzymopathy?
A. Pseudocholinesterase
B. N-acetyltransferase
C. Uridine diphosphate glucuronyltransferase
D. Glucose 6-phosphate dehydrogenase
E. Methemoglobin reductase
During a surgery on the submandibular salivary gland, the patient developed bleeding.
What artery, topographically connected with this gland, can cause bleeding?
A. Superficial temporal artery
B. Maxillary artery
C. Facial artery
D. Ascending pharyngeal artery
E. Carotid artery
The level of tissue excitability needs to Be measured in an experiment. For this purpose
one should determine:
A. Action potential duration
B. Action potential amplitude
C. Depolarization threshold
D. Resting potential
E. Critical level of depolarization
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8. An 18-year-old woman has disproportioned body, wing-like folds on the skin of her
neck, underdeveloped ovaries, the nuclei of her buccal epithelium cells have no Barr
bodies. What provisional diagnosis can be made in this case?
A. Turner syndrome
B. Patau syndrome
C. Kleinfelter syndrome
D. Edward syndrome
E. Cri du chat (cat cry) syndrome
A 37-year-old woman complains of headache, vertigo, troubled sleep, numbness of
limbs. For the last 6 years she has been working at the gas- discharge lamp-producing
factory in a lead-processing shop. Blood test findings: low hemoglobin and RBC levels,
serum iron concentration several times exceeds. The norm. Specify the type of anemia:
A, Minkowsky-Shauffard disease
B. Iron refractory anemia
C. Iron-deficiency anemia
D. Metaplastic anemia
E. Hypoplastic anemia
Signs of pellagra (vitamin PP deficiency) are particularly pronounced in patients with
low protein diet, because in the human body the nicotinamide precursor is one of the
essential amino acids. Name this amino acid:
A. Arginine
B. Threonine
C. Histidine
D. Lysine
E Tryptophan
Patients with ischemic heart disease are usually prescribed small doses of aspirin. This
drug inhibits synthesis of platelet aggregation activator, thromboxane A2. What
substance is this activator synthesized from?
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A. Acetic acid
B. Malonic acid
C. Glutamic acid
D. Homogentisic acid
E. Arachidonic acid
12 A patient complains of pain in the upper umbilical region. On palpation there is a
mobile painful intestine. What intestine is being palpated by the doctor?
A. Sigmoid colon
J. Transverse colon
C. Ileum
D. Jejunum
E. Duodenum
Examination of boy's external genitalia Revealed a full closure of the upper part of
urethra. The urethral canal remains open only from below, as a small fissure. What
developmental anomaly of the external genitalia can be observed in this case?
A. Hypospadias
B. Epispadias
C Phimosis
D. Hermaphroditism
E. Paraphimosis
The key reaction of fatty acid synthesis production of malonyl-CoA. What metabolite is
the source of malonyl-CoA synthesis?
A. Citrate
B. Acetyl-CoA
C. Malonate
D. Succinyl-CoA
E. Acyl-CoA
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The obstetrician-gynecologist measuring the pelvis of a pregnant woman. A caliper was
used to measure the distance between her iliac crests. What pelvic size was measured?
A. Distantia spinarum
B. Distantia cristarum
C Distantia throchanterica
D. Conjugata anatomica
E. Conjugata vera
Four months after a stroke, a man was brought in for rehabilitation with signs of central
paralysis. Objectively, his right arm and leg are immobile, their muscle tone is
increased, local reflexes are intensified. What term should be used to describe the
patient's condition in this case?
A. Functional paralysis
B. Paraplegia
C. Tetraplegia
D. Monoplegia
E. Hemiplegia
A medical student was hospitalized to the infectious diseases unit on the 2nd day after
the discase onset. The patient is suspected to have infectious mononucleosis. What
results of laboratory analysis can confirm this diagnosis immediately on the day of the
hospitalization?
A. Fourfold increase in the number of antibodies to Epstein-Barr virus was DETECTED
B. IgM antibodies to Epstein-Barr virus was detected
C IgM antibodies to herpes simplex virus were detected
D. Herpesvirus was isolated
E. Cytomegalovirus antibodies were detected
An experiment was aimed at testing the flexor reflex in a spinal frog, which was initiated
by simultaneous stimulation with isolated pre-Threshold electrical impulses The
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frequency of those impulses was such, that the reflex occurred. What process in the
nerve centers can be observed during this experiment?
A. Threshold summation
B. Postsynaptic summation
C. Spatial summation
J. Presynaptic summation
E. Temporal summation
An oncology patient is to undergo a surgery on the descending colon. Name the main
source of blood supply to this organ:
A. Splenic artery
B. Celiac trunk
e Inferior mesenteric artery
D. Middle colic artery
E. Superior mesenteric artery
A patient with pulmonary tuberculosis prescribed a specific antituberculosis antibiotic.
Name this drug:
A. Streptocide
B. Eurasolidone
C. Rifampicin
D. Bactrim (Co-trimoxazole)
E. Doxycycline
A 30-year-old patient's blood test Revealed the following: erythrocyte count is 6. 10/L.
hemoglobin is 10.55 mmol/L. Vaquez's disease was diagnosed. Name the leading part
of the pathogenesis in this case:
A. Iron-deficiency
B. Acidosis
C. Biz-deficiency
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D. Hypoxia
E. Neoplastic erythroid hyperplasia
A patient with periodontitis of the lower molar came to the doctor. It was determined that
the inflammatory process spread to the lymph nodes. What lymph nodes were the first
to be affected by the inflammatory process?
A. Facial
B. Lateral cervical
C. Anterior cervical
D. Submental
E. Submandibular
Examination of the femoral bone detected chronic suppurative inflammation of the
compact substance and bone marrow, formation of bone sequestrate. What disease is
associated with such changes?
A. Reticulosarcoma
B.Osteomyelitis
C. Periostitis
D. Multiple myeloma
E. Giant cell tumor of bone
A patient has developed paroxysmal ventricular tachycardia against the background of
cardiac infarction. What antiarrhythmic drug should be chosen to avoid lowering the
cardiac output?
A. Verapamil
B. Potassium chloride
C. Novocainamide (Procainamide)
D. Lidocaine hydrochloride
Apaprilin (Propranolol)
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25 A 15-year-old teenager complains general weakness, dizziness, and rapid
fatigability. Examination detected deformed erythrocytes, their number is decreased.
The provisional diagnosis of sickle-cell anemia was made. What amino acid
replacement in hemoglobin causes the development of this pathological condition?
X. Glutamate replaced with valine
B. Valine replaced with aspartate
C. Glutamate replaced with alanine
D. Glutamate replaced with aspartate
E. Valine replaced with glutamate
Antileukocytic antibodies are detected in the blood of a patient with leukopenia. What
type of Coombs-Gell hypersensitivity reaction developed in this case?
A. immune complex-mediated
B. Cytotoxic
C. Stimulating
D. Delayed-type hypersensitivity
E. Anaphylactic
27) Those organisms, which in the process of evolution failed to develop protection from
H2o2, can exist only in anaerobic conditions. Which of the following enzymes can break
down hydrogen peroxide?
A. Cytochrome oxidase, cytochrome B5
B. Flavin-dependent oxidase
e Peroxidase and catalase
D. Oxygenase and hydroxylase
E. Oxygenase and catalase
Examination of the duodenal contents revealed there pear-shaped protozoa with two
nuclei and four pairs of flagella. The organisms have two axostyles between the nuclei
and a ventral adhesive disc. What protozoan representative was found in the patient?
A. Intestinal trichomonad
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B. Lamblia
C. Trypanosome
D. Leishmania
E. Toxoplasma
A 48-year-old man is unconscious. He has a history of several syncopal episodes with
convulsions. ECG shows deformed ORS complexes unconnected with P waves, atrial
are approximately 70/min., ventricular contractions are 25-30/min. Name the type of
arrhythmia in this case:
A. first-degree atrioventricular block
B. Complete atrioventricular block
C. Second-degree atrioventricular block
D. Intraatrial block
E. Intraventricular block
(30) Parents of a 5-year-old sick girl came to the genetic consultancy. Examination of
the child's karyotype shows 46 chromosome. One of the chromosomes in the 15th pair
is longer than normal, because it has a fragment of 21st chromosome attached to it.
What type of mutation is observed in the girl?
A. Deficiency
B. Deletion
C. La version
3. Translocation
E. Duplication
21 A 35-year-old patient has been Administered a depolarizing muscle relaxant during a
surgery. Name this drug:
A. Proserin
B. Aminazine
C. Rocuronium
B. Dithylinum
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E. Atracurium
A biopsy material was obtained from the arches of the patient's soft palate due to a
suspected tumor (macroscopy detected an ulcer with the dense floor). In the biopsy
material the following was detected: necrosis of the mucosa with infiltration of the
submucosal layer by lymphocytes, epithelioid cells, plasma cells, and single neutrophils.
Notable is the presence of marked endovasculitis and perivasculitis. The described
changes are characteristic of:
A. Primary syphilis
B. Pharyngeal diphtheria
C. Aphthous stomatitis
D. Necrotizing ulcerative stomatitis
E. Ulcerative stomatitis
Encephalopathy has developed in child with hemolytic disease of the newborn. What
substance increased in the child's blood, resulting in damage to the CNS?
A. Bile acids
B. Bilirubin-albumin complex
C. Bilirubin glucuronide
D. Verdohemoglobin
E. Unconjugated bilirubin
Therapeutics unit of a hospital received man suffering from hyperacid peptic ulcer
disease of the stomach. Which of the listed group of drugs must be used as a part of the
complex therapy for this patient?"
A. Nonsteroidal antiinflammatory drugs
B. Histamine H1-receptor blockers
e Histamine H2-receptor blockers
D. Steroidal antiinflammatory drugs
E. Calcium channel blockers
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A 41-year-old man has a history recurrent attacks of heartbeats (paroxysms).profuse
sweating, headaches Examination revealed hypertension hyperglycemia, increased
basal metabolic rate, and tachycardia. These clinical presentations are typical of the
following adrenal pathology
A. Hyperfunction of the adrenal cortex
B. Hypofunction of the adrenal cortex
C. Hypofunction of the medulla
D. Primary aldosteronism
E. Hyperfunction of the medulla
36 A 62-year-old patient has been hospitalized due to massive cerebral hemorrhage.
Blood pressure is 70/30 mm Hg. heart rate is 120/min., respiratory rate is 4/min.,
unconscious, no response to external stimuli. Such condition can be determined as:
A. Agony
B. Coma
e Shock
D. Stress
E. Collapse
A person becomes less receptive to pain in physically or emotionally straining situations
due to activation of:
A. Antinociceptive system
B. Parasympathetic nervous system
C. Adrenal glands functions
D. Nociceptive system
E. Thyroid gland functions
A boy has a large trema between his incisors. It is known that the gene for this anomaly
is the dominant one. This boys natural sister has normal teeth placement. It means that
genotypically she is:
A. di Heterozygous
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B. homozygous-recessive
C. Heterozygous
D. Homozygous-dominant
E. Triheterozygous
39. A 50-year-old woman with a long History of glomerulonephritis died with progressing
signs of intoxication (uremia). Autopsy shows thickened wall of the large intestine, with
a gray-white film on the mucosa The film is tightly attached to the underlying tissues. On
the pleura there are grayish films that can be easily removed. What type of inflammation
can be observed?
A. In the large intestine croupous inflammation, on the pleura – diphtheritic
inflammation.
B. In the large intestine diphtheritic inflammation, on the pleura – croupous
C. In the large intestine - suppurative inflammation, on the pleura – croupous
D. In the large intestine - serous catarrh inflammation, on the pleura - croupous
E. In the large intestine – suppurative inflammation, on the pleura – diphtheritic
A 46-year-old woman suffering from Cholelithiasis developed jaundice. Her urine
became dark yellow, while feces are light-colored. What substance will be the most
increased in concentration in the blood serum in this case?
A. Urobilinogen
B. Mesobilirubin
C. Biliverdine
D. Conjugated bilirubin
E. Unconjugated bilirubin
41.
Histological examination of the biopsy material obtained from the lower third of
the esophagus of 57 year old man with the signs of continuous reflux revealed the
change of the stratified squamous epithelium to the single layer columnar glandular
epithelium with signs of mucus production. Specify the pathological process in the
mucuos membrane.
A.
Hyperplasia
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B.
Hypertrophy
C.
Regeneration
D.
Metaplasia
E.
Organisation
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42.
A 40 year old woman with Cushing disease has steroid diabetes biochemical
examination shows hyperglycemia and hyperchloremia . what process activates in the
first place in such patient?
A. Glycogenolysis
B. Glucose transportation into a cell
C. Glucose reabsorption
D. Gluconeogenesis
E. Glycolysis
43.A 35 year old man complains of a severe rhinitis and a loss of the sense of smell for
a week. Examination detected in the nasal cavity a large amount of mucus that covered
the mucosa and blocked the olfactory receptors Where in the nasal cavity are these
receptors located?
A.
middle nasal concha
B.
common nasal meatus
Vestibule of the nose
Superior nasal concha
Inferior nasal concha
44 . To loose some weight women has been Limiting the amount of protein in her diet .
Three months later she developed edemas and her diuresis increased. What dietary
components deficiency is the cause of this?
A.Vitamins
B.carbohydrates
C.Fats
D.
Minerals
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E.
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Proteins
45.T lymphocytes are determined to be affected by HIV .in this case viral enzyme
reverse transcriptase (RNA_dependent DNA polymerase) catalysis the synthesis.
A.Viral DNA based on the DNA matrix
B.Viral RNA based on the DNA matrix
C.DNA based on the viral RNA matrix
D.Information RNA based on the viral protein matrix
E.Viral protein based on the viral RNA matrix
45.
For the study of serum proteins various physical and physio chemical methods
can be used . in particular serums Albumins and globulins can be separated by this
method
A.Electrophoresis
B.refractometry
C.polarography
D.Dialysis
E.spectrophotometry
47.A patient consulted a dentist about limited mouth opening (trismus).he has a history
of a stab wound of the lower extremity what infection can cause these symptoms?
A.pertusis
B.tularemia
C.tetanus
D.rabies
48 Autopsy of the body of a 15 year old child revealed moderate hyperemia and edema
of nasopharyngeal mucosa small hemorrhages in mucosa and internal organs ,
markedly dystrophic changes in the liver and myocardium, acute necrotic nephrosis,
and massive hemorrhages in the adrenal glands. These changes are characteristic of
the following disease
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A.
Diphtheria
B.
Scarlet fever
C.
Meningococcal disease
D.
Measles
E.
Epidemic typhus
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49.A patient After disrupted cerebral circulation has developed paralysis choose the
anticholinesterase drug To be prescribed in this case
A. methacin
B. proserin
C. Aceclidine
D. Benzohexonium (hexamethonium)
E. cordiamin
50.A specimen of a parenchymal organ shows poorly delineated hexagonal lobules
sorrounding a central vein .The intralobular connective tissue contains embedded triads
(and artery and vein and an excretory duct ) what organ is it?
A.
Thymus
B.
Spleen
C.
thyroid
D.
E.
pancreas
liver
51.
Granulomas Containing lymphocytes and macrophages were detected during
analysis of skin biopsy material. Among macrophages there are large cells with fat
inclusions which contains microorganisms in spheric packages (Virchow’s cells) what
disease is based on the described type of hypersensitivity
A.
Epidemic typhus
B.
Tuberculosis
C.
Rhinoscleroma
D.
Syphilis
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Leprosy
52.
A sample of ovoid non motile bacteria with bio polar staining was obtained from a
patient in the body they form a soft capsule. Inoculated on agar they grow Colonies with
an off white Dead with a scalloped border resembling lace.They produce mice toxin
what causative agent has such characteristics?
A.
Tularaemia
B.
Brucellosis
C.
plague
D.
pertussis
53.
Microscopy of women’s swabs made from vaginal secretions revealed Gram
negative bean shaped diplococci. What provisional diagnosis can be made?
A.
gonorrhoea
B.
toxoplasmosis
C.
chlamidiasis
D.
syphillis
E.
mycoplasmosis
55.
A 60 year old with Chronic hepatitis frequently develops nosebleeds and
bleeding gums hemorrhagic rash spontaneously develops on his skin mucosa .What is
the cause of this phenomena?
A.
appearance of macroglobulins and cryoglobulins in the blood
B.
decreased blood levels of choline esterase
C.
Decreased synthesis of prothrombin and fibrinogen
D.
Decreased formulation of serum albumin
E.
Increased levels of aminotransferase
56 . A 40 year old woman during examination present with intensified basal metabolic
rate. What hormone present in excess , leads to such condition?
A.
triiodothyronine
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B.
glucagon
C.
thyrocalcitonin
D.
somatostatin
E.
Aldosterone
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57.
An conscious young man in the state of morphine intoxication has been brought
into an admission room. The patients respiration is slow and shallow due to suppression
of the respiratory center what kind of respiratory failure occurred in this case?
A.
perfusion
B.
Ventilatory restrictions
C.
Ventilatory dysregulation
D.
diffusion
58.
A man with constant headache pain in the occipital region tinnitus, dizziness has
been admitted to the cardiology department. objectively his blood pressure is
180/110mm Hg, heart rate 95/min . Radiographically there is a stenosis of one of the
renal arteries. Hypertensive condition in the patient has been caused by the activation
of the following system.
A.
Hemostatic
B.
Immune
C.
Renin_ angiotensin
D.
Sympathoadrenal
E.
Kinin
59 Patient for a long time was on imbalance diet low in proteins which resulted in
hepatic fatty infiltration. this condition is likely to develop if a certain substance is absent
in a persons diet . Name the substance:
A.
Alanine
B.
Methionine
C.
Biotin
D.
Cholesterol
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Acetic acid
60. Depression an emotional disturbance result from the lack of noradrenaline .
serotonin and other biogenic amines in the brain . Their levels in the synapses can be
increased through administration of antidepressants that inhibit the following enzyme:
A.
Diamine oxidase
B.
Monoamine oxidase
C.
Phenylalanine monoxygenase
D.
L amino oxidase
D
amino acid oxidase
61 . Leading Terms of a primary hyperparathyroidism are osteoporosis and renal
damage. Resulting in urolithiasis development. What substances make up the basis
uroliths in such cases?
A.
Cholesterol
B.
Bilirubin
C.
Cystine
D.
Calcium phosphate
E.
Uric acid
62.
A 67 year old man with clinical diagnosis of Chronic bronchitis, pneumosclerosis
An cardiopulmonary decompensation has the biopsy material taken from the suspicious
area in his right bronchus mucosa. Cellular and tissue atypism along with pearly bodies
can be histological detected. What pathologic process is characterized by the described
histological changes?
A.
Bronchiectasis
B.
polypoid chronic bronchitis
C.
Squamous cell carcinoma of bronchus with keratinization
D.
Acute bronchitis
E.
Squamous cells metaplasia of bronchial mucosa
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63.
Coronary artery thrombosis resulted in development of myocardial infarction.
What mechanism of cell damage are leading in this disease?
A.
protein
B.
Lipid
C.
Electroosmotic
D.
Calcium
E.
Acidotic
64.
Name the supramolecules are multi enzyme complex that is integrated into the
lipid layer of inner mitochondrial membrane that creates condition for redox reactions
A.
pyruvate kinase
B.
G protein transducer
C.
Hexokinase
D.
Carboxypeptidase
E.
Respiratory chain
65.
Experimental stimulation off sympathetic nerve branches that innervate heart
caused an increase in the force of heart contraction’s because the membrane of typical
cardiomyocytes permitted an increase in:
A.
calcium and potassium ion influx
B.
Potassium ion efflux
C.
Calcium ion efflux
D.
Calcium ion influx
E.
potassium ion entry influx
66.
During acute hemorrhage the body loses not only fluid but also electrolytes what
substance solution can be used as A simple blood substitute?
A.
Sodium nucleotide
B.
Albumin
C.
Sodium bromide
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D.
sodium chloride
E.
Calcium chloride
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67.A patient complaints that at the bare mention of the tragic events that once occurred
in his life he experiences tachycardia ,dyspnea and an abrupt rise in the pressure .what
structures of the CNS Are responsible for these cardiorespiratory reactions in the
patient?
A.
Quadrigemina of the mesencephalon
B.
cerebral cortex
C.
Specific thalamic nuclei
D.
Cerebellum
E.
Lateral hypothalamic. Nuclei
68 . A 13 year old teen-ager underwent X ray examination of the hip joint. Examination
revealed a 3 mm wide radiolucent zone between the head and the shaft of the femur.
This situation should be regarded as
A.
Normal incomplete ossification
B.
Dislocation of the femoral head
C.
Radiographic fil artifact
D.
Fissured fracture of femoral neck
E.
Fracture of the femoral neck
69 UN Volunteers have arrived in Nigeria to assist the locals in the aftermath of
earthquakes. What drug should they prescribe for individual chemo prophylaxis of
malaria?
A.
laferon
B.
Pyrantel
C.
primaquine
D.
chloridinium (pyrimethamine)
E.
chingamin
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70.
During autopsy of the body of a man who had been suffering from mitral stenosis
the lungs revealed to be dense and Brown colored what pathologic process had
occurred in the lungs?
A.
Hemochromatosis
B.
lipofuscinosis
C.
Hemomelanosis
D.
jaundice
E.
Hemosiderosis
71.
A bioterrorist mailed and enveloped with the powder that is suspected to contain
anthrax causitive agent. This envelop can remain dangerous for a long time, because
anthrax causative agent agent.
A.
forms a polysaccharide capsule
B.
forms flagella
C.
belongs to actinomycetes
D.
is a spore former
E.
forms a protein capsule
72.
During a surgery performed in abdominal cavity, a surgeon located a ligament of
liver, stretching from the Anterior abdominal wall (navel) to the interior surface of liver.
What ligament is it?
A.
Falciform ligament of the liver
B.
triangular ligament of the liver
C.
round ligament of the liver
D.
Coronary ligament of the liver
E.
venous ligament of the liver
73.
In a hypothetical experiment the action of a toxic substance disrupts the
mechanism of nerve impulse transmission between neurons. What structure enables
this function?
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A.
Mitochondrion
B.
Neurofibril
C.
synapse
D.
neuroleprescribnce
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74.
18 year old patient has developed candidiasis after the case of pneumonia
treated with beta lactam antibiotic. What antimycotic should be prescribed?
A
streptomycin
B.
Phthalazol(phthalysulfathiazole)
C.
Ampicillin
D.
flucanozole
E.
biseptol (Trimethoprim+ sulfamethoxazole)
75.
Patient with clinical signs of a primary immunodeficiency, presents with
functionally disturb mechanism of antigen presentation to the immunocompetent cells .
what cells that are likely to have structural defect?
A.
B lymphocytes
B.
o lymphocytes
C.
T lymphocytes
D.
fibroblast
E.
Macrophages, monocytes
76.
A 40 year old man with pulmonary tuberculosis was prescribed isoniazid.
Prolonged taking of this drug can be result in the deficiency of vitamin?
A.
Thiamine
B.
pyridoxine
C.
cobalamin
D.
biotin
E.
folic acid
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77.
During ascent into mountains a person developed increased respiration rate and
rapid heart rate. What is the cause of these changes?
A.
Increase of blood pH
B.
Increase of nitrogen content in air
C.
Increase of air humidity
D
increase of co2 partial pressure
E.
Decrease of O2 partial pressure
78.
A 9 year old boy an acute onset of the disease sore throat, body temperature of
39°5°c .On the second day diffuse skin rash detected all over his skin except for the
nasolabial triangle. Examination of oral cavity shows crimson tongue , flaming pharynx ,
necrotic tonsillitis?
A.
Meningococcemia
B.
Influenza
C.
Diptheria
D.
measles
E.
Scarlet fever
79.
initial inoculation of water in 1% peptone water result in growth of a thin film on
the medium surface in 6 hours such cultural properties are characteristics of the
causative agent of the following disease
A.
cholera
B.
tuberculosis
C.
pseudotuberculosis
D.
Dysentery
E.
plague
80.A patient with lobar pneumonia has had body temperature of 39°c with daily
Temperature fluctuations of no more than 1°c for 9 days .this fever can be characterized
by the following temperature curve.
A.
recurrent
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B.
Hyper pyretic
C.
Persistent
D.
Hectic
E.
remittent
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81. Old burial ground for animal refuse which has not been in use for the last 50 years,
is planned to be given for housing development. However, the soil analyses detected
valuable spores of a causative agent of an extremely dangerous disease. What
microorganism is the most likely to remain in the soil for such long periods of time?
A
tularemia
B
brucella
C.
Bacillus anthracis
D.
Mycobacterium bovis
E.
Brucella abortus
Autopsy of a man, who served in a nuclear submarine, revealed the following
pathologies: bone marrow atrophy (panmyelophthisis), anemia, leukopenia,
thrombocytopenia, lymphocytes disintegration in the lymph nodes, spleen,
gastrointestinal lymphatic system, and hemorrhages into the adrenal glands. What
disease developed in this case?
A. Vibration disease
B. Acute anemia
C Acute leukemia
D. Decompression sickness
Acute radiation sickness
A woman with a dense area in her mammary gland came to a surgeon. To minimize the
trauma to the mammary gland lobule during the operation, the surgeon should make the
incision:
A
B. Radially
C Arcuately
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D. Transversely
E. Vertically
During ventricular systole, the cardiac muscle does not respond to additional stimulation
because it is in the phase of
B. Absolute refractoriness
C. Hyperexcitability
D. Subnormal excitability
E. Relational refractoriness
A 65-year-old woman, who had been suffering from deep vein thrombophlebitis of the
lower leg suddenly died when awaiting her appointment with the doctor Autopsy
revealed loose friable red masses with corrugated dull surface in the main pulmonary
artery and its bifurcation. What pathologic process was discovered by the pathologist in
the pulmonary artery?
A. Thrombosis
B. Foreign body embolism
Thromboembolism
D. Fat embolism
E.Tissue embolism
(86. Blood pressure of an adult person has Cropped from 120/70 to 90/50 mm Hg.
which caused a reflex vasoconstriction. In what organ will the vasoconstriction be
minimal?
A. Heart
B. Skin
E Intesting
D. Skeletal muscles
E Liver
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A newborn presents with weak suckling. frequent vomiting, and hypotonia. Blood and
urine citrulline are very high. What metabolic process is disturbed?
X. Ornithine cycle
B. Glycolysis
C. Gluconeogenesis
D. Tricarboxylic acid cycle
E Coricycle
88.) A 12-year-old child has developed nephritic syndrome 2 weeks after a case of
tonsillitis, which is a sign of affected glomerular basement membrane in the kidneys.
What mechanism is the most likely to cause the basement membrane damage?
X. Cytotoxic
B. Réaginic
e Immune complex
D. Antibody-mediated
E. Granulomatous
89. After dehelmintization, a 35-year-old man passed a 3.5 m tapeworm during a bowel
movement. A stool examination reveals scolex with four suckers and hooks. Mature
proglottids are static with up to 12 primary uterine branches. Which of the following is
the most likely diagnosis?
Taeniasis
B. Diphyllobothriasis
C Opisthorchiasis
D. Echinococcosis
E.-
Due to the blockage of the common bile duct which was radiographically flow to
duodenum was stopped. We should expect the impairment of
A. Secretion of hydrochloric acid
B. Carbohydrate hydrolysis
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fat emulsification
D. Protein absorption
E. Salivation inhibition
91. Due to prolonged stay in the mountains at the altitude of 3000 m above the sea
level, a person developed increased oxygen capacity of blood which was directly
caused by intensified production of:
A Catecholamines
X. Erythropoietins
C. 23-bisphosphoglycerate
D. Carbaminohemoglobiny
E. Leukopoietins
92. Influenza progression was later accompanied by respiratory mycoplasmosis in a 12year-old boy. What type of infection developed in this case?
A. Mixed infection
B. Superinfection
C. latrogenic infection
D. Relapse
E. Auldinfection
A family of healthy students, who have arrived from Africa, gave birth to a child with
signs of anemia. The child died shortly after. Examination revealed that the child's
erythrocytes were abnormally crescent-shaped. The disease has autosomal recessive
inheritance pattern. Determine the genotype of the child's parents:
А. Аах Аа
B. aa xaa
C. Aa x AA
D. AA X AA
Е. Аа хаа
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(94)A patient demonstrates functional loss of nasal halves of the retinas. What area of
visual pathways is affected?
A. Right optic tract
B. Lelt optic tract
C. Bight optic nerve
D. Optic chiasm
E. Let optic nerve
A 64-year-old woman presents with disturbed fine motor function of her fingers, marked
muscle rigidity and tremor. The neurologist diagnosed her with Parkinson's discase.
What brain structures are damaged, resulting in this disease?
A. Substantia nigra
B. Cerebellum
C. Thalamus
D. Red nuclei
E. Reticular formation
A woman, who has been suffering from marked hypertension for 15 years, has lately
developed dyspnea. palpitations, slightly decreased systolic pressure, while diastolic
pressure remains the same. What is the main mechanism of heart failure development
in this case?
X. Cardiac overload due to increased blood volume
B. Dysregulation of cardiac function
c Cardiac overload due to increased vascular resistance
D. Dis of impulse conduction in the myocardium
E. Damage to the myocardium
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Among lymphocytes there is a population of cells that have membrane receptors to IgM,
activate in response to certain antigens, reproduce mitotically, differentiate into plasma
cells that produce antibodies (immunoglobulins) Name these cells:
A. Killer T cells
B. B lymphocytes
C. Memory T cells
D.
E. Suppressor T cells
During local anesthetization the patient has gone into anaphylactic shock What drug
must be administered to the Patent
A. Adrenaline hydrochloride
B. Atropine sulfate
C.Suprastin (Chloropyramine)
D. Diazepam
E. Prednisolone
A patient has gradually developed skin plaque on his face. In the center of this plaque
there are a necrotic patch and in ulcer. Histopathological analysis of the biopsy material
reveals proliferation of atypical epithelial cells with large number of pathologic mitoses
What is the most likely diagnosis?
A. Trophic ulcer
B. Sarcoma
C Fibroma
D. Papilloma
Skin cancer
A 30-year-old man with diabetes mellitus type I was hospitalized. The patient is
comatose. Laboratory tests revealed hyperglycemia and ketonemia. What metabolic
disorder can be detected in this patient?
A. Respiratory alkalosis
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B. Normal acid-base balance
C. Metabolic alkalosis
D. Metabolic acidosis
Respiratory acidosis
(101. A risk of cerebral EDema arose in a Narcotized patient. What drug should be
administered in this case?
A. Dopamine
B. Triamterene
C. Spironolactone
1. Sodium bromide
E. FURESEMIDE
A patient has problems with motor function of the tongue, which indicates a
pathology of the following nerve:
A. Facial nerve
B. Glossopharyngeal nerve
C. Vagus nerve
D. Hypoglossal nerve
2. Trigeminal nerve
A 6-year-old child suffers from delayed growth, disrupted ossification processes,
decalcification of the teeth. What can be the cause?
A. Vitamin D deficiency
B. Insulin deficiency
C. Hyperthyroidism
D. Decreased glucagon production
E. vitamin C deficiency
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Examination of a 56-year-old woman with a history of type 1 diabetes mellitus revealed
a disorder of protein metabolism that in the laboratory blood test values is manifested as
aminoacidemia, and clinically - as delayed wound healing and decreased synthesis of
antibodies. Which of the following mechanisms causes the development of
aminoacidemia?
Hyperproteinemia
Increased proteolysis
Decreased concentration of amino acids in blood
D. Increased oncotic pressure in the bloodplasma
E. Increased levels of high-density lipoproteins
105) A man is prescribed an enzymatic drug with cytochrome C. This enzyme
intensifies the following process:
A. Glycolysis
B. Tricarbonic acid cycle
C Phospholipid synthesis
D. Tissue respiration
E. Collagen synthesis
A patient was diagnosed with alkaptonuria. This pathology is caused by a defect in the
following enzyme:
A. DOPA decarboxylase
B. Homogentisic acid oxidase
c. Glutamate dehydrogenase
D. Pyruvate dehydrogenase
E. Phenylalanine hydroxylase
(107. Renal examination shows the kidney to be swollen and plethoric, with easily
removable capsule Renal pelvis and calyces are dated and filled with turbid urine; their
mucosa is dull and has hemorrhagic foci. On section the renal tissue is variegated,
there are yellow- gray areas surrounded with plethoric and hemorrhagic zone. What
disease can be characterized by such results of macroscopic examination?
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A. Nephrolithiasis
B. Polycystic kidney
C. Acute pyelonephritis
W. Acute glomerulonephritis
E. Repal amyloidosis
(108) A woman complains of vision Impairment. On examination she was found to have
obesity and fasting hyperglycemia. What can be the cause of vision impairment in this
case?
A. Diabetic macroangiopathy
B. Glomerulopathy
C. Diabetic microangiopathy
B. Diabetic neuropathy
E. Atherosclerosis
A 30-year-old woman-exhibits Signs of virilism (growth of body hair, balding temples,
menstrual disorders). This condition can be caused by the overproduction of the
following hormone:
A. Oxytocin
B. Progesterone
C. Oestriol
D. Testosterone
E Relaxin
Typical manifestations of poisoning caused by C. botulinum are double vision,
abnormal functioning of the swallowing and breathing. These symptoms develop as a
result of:
A. Enterotoxin effects
B. Enterotoxic shock development
C. Activation of adenylate cyclase
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D. Exotoxin effects
E. Pathogen adhesion to the enterocyte receptors
During examination of a patient a doctor should use anatomical division of anterior
abdominal wall into regions for more precise diagnostics. How many such regions can
abdomen be divided into?
A. 6
B.4
2.9
D.8
E.5
(112 Corticosteroid hormones, regulate adaptation processes of the body as a whole to
environmental changes and ensure the maintenance of internal homeostasis. What
hormone activates the hypothalamo-pituitary-adrenal axis?
A. Sematoliberin
B. Somatostatin
C Thyroliberin
D. Corticostatin
E. Corticoliberin
(113. Pupil dilation occurs when a person Steps from a light room into a dark one. What
reflex causes such a reaction?
A Sympathetic conditioned reflex
B. Sympathetic unconditioned reflex
C. Parasympathetic unconditioned reflex
D. Metasympathetic reflex
E. Parasympathetic conditioned reflex
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(114. Human skin has very high tensile Strength. It is known that the skin consists of
epithelial tissue and two kinds of connective tissue. Which of the following tissues
provides the skin strength?
A Transitional epithelium
H. Stratified squamous epithelium
C. Loose connective tissue
D. Single-layer epithelium
E. Unformed dense connective tissue
A patient with myocardial infarction in the acute phase has been hospitalized into the
cardiology unit. To induce platelet lysis in the patient's coronary vessels during the early
hours of infarction, the following enzyme should be used:
A. Trypsin
B. Chymotrypsin
C. Lidase (Hyaluronidase)
J. Lysozyme
E. Streptokinase
An unconscious man was brought the admission room. He presents with cold skin,
constricted pupils, difficult respiration with Cheyne-Stokes pattern, low blood pressure,
overfilled urinary bladder. He was diagnosed with morphine poisoning. What drug
should the patient be given as an antagonist in this case?
A. Sodium thiosulfate
B. Cytitone
C. Unithiol
D. Bemegride
Naloxone
A patient with chronic bronchitis was prescribed a drug with mucolytic action. Name this
drug:
A, Ambroxol
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Glaucine hydrochlorido
C. Codeine
D. Paracetamol
E, Anaprilin (Propranolol)
As a result of a craniocerebral injury, patient presents with decreased skin sensitivity.
What area of the cerebral cortex is likely to be damaged?
A. Anterior central gyrus
2. Posterior central gyrus
C. Frontal cortex
D. Occipital region
E. Cingulate gyrus
Prolonged taking of a certain medicine can result in osteoporosis, gastric mucosal
erosions, hypokalemia. Sodium and water retention, and decreased blood content of
corticotropine. Specify this medicine:
. Prednisolone
B. Indometacin
C. Digoxin
D. Rilampicin
E. Hypothiazid (Hydrochlorothiazide)
120. A patient with parkinsonism was prescribed levodopa, which led to rapid
improvement of the patient's condition What is the mechanism of action of this drug?
A. Stimulation of dopamine synthesis
B. Muscarinic acetylcholine receptor stipulation
Stimulation of dopamine receptors
D. Muscarinic acetylcholine receptor blockade
E. Anticholinesterase action
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121) An 11-year-old girl is brought to the doctor's office by her mother who states that
her daughter has been presenting with weakness and swollen face for 3 days. The
mother claims that her daughter had always been healthy and active until the initiation
of symptoms. Upon inquiry the girl describes a foamy appearance of her urine but
denies blood in urine, urinary frequency at night, or pain during urination. Physical
examination reveals generalized swelling of the face and pitting edema on the lower
limbs. Laboratory study shows proteinuria and microscopic hematuria. Which of the
following is the most likely cause of findings in the laboratory study of urine?
A. Increased glomerular hydrostatic pressure
B. Increased hydrostatic pressure in the Bowman's capsule
C. increase plasma oncotic pressure
J. Increased permeability of the glomerular capillary wall
122. Autopsy of a dead patient, who died from pulmonary edema, revealed a large
yellow grey nidus in the myocardium, and a fresh thrombus in the coronary artery What
is the most likely diagnosis?
A. Myocarditis
8. Cardiosclerosis
C. Cardiomyopathy
B. Myocardial infarction
E. Amyloidosis
A 3-year-old child had eaten some Strawberries, Soon he developed a rash and itching
What was found in the child's leukogram?
A. Lymphopenia
B. Eesinophilia
Neutrophilic leukocytosis
D. Lymphocytosis
E. Monocytosis
124. A patient with inoperable lung cancer accompanied by unbearable pain was
prescribed an analgesic. Against the background of analgesic therapy the patient
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developed signs of intestinal obstruction. What analgesic could havecaused this
complication?
A. Analgin (Metamizole)
B. Fentanyl
C Morphine
D. Omnopon (Papaveretum)
E Promedol (Trimeperidine)
125. During cholecystectomy besides cystic another artery was pulled into the ligature.
Ligation of this artery resulted in right-sided necrosis of the liver which led to the death
of the patient. What artery was mistakenly ligated along with a cystic?
A. A. pancreato-duodenalis sup
B. A hepatica communis
C. Ramus sinister a hepatica propria
P. Ramus dexter a hepatica propria
E. A. poro-duodenalis
A man, complaining of infertility, has made an appointment with the doctor. He has tall
stature, low intelligence, and underdeveloped gonads. His oral mucosa epithelium has
sex chromatin (1 Barr body). What pathology can be suspected in this case?
A. Cushing syndrome
B. Acromegalia
C. DiGeorge syndrome
D. Adrenogenital syndrome
Klinefelter syndrome
During histological analysis of the lymph node located in the posterior neck triangle of
an 18-year-old patient, a morphologist detected a cluster of cells, among which there
were isolated multinucleate Reed-Sternberg cells, large and small Hodgkin's cells,
numerous lymphocytes isolated plasma cells, and eosinophils. What disease has
developed in the patient?
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A. Burkitt's lymphoma
B. Lymphocytic lymphoma
Lymphogranulomatosis
D. Chronic lymphocytic leukemia
E. Nodular lymphoma
128. Against the background of prolonged heparin treatment, the patient developed
gastric bleeding. What specific heparin antidote must be used in this case ?
A. Sodium citrate
B. Dipiroxim (Ttrimedoxime bromide)
Vicasol (Menadione)
D. Bemegride
E Portamine sulfate
129) Histological specimen shows organ parenchyma that consists of lymphoid tissue
and forms lymph nodules. The nodules are located diffusely and have a central artery.
What anatomical structure has such morphological characteristics?
A. Thymus
Jl. Spleen
C. Liver
D. Red bone marrow
E Lymph node
(130. A 3-year-old child has been brought ambulance to the intensive care unit of the
infectious diseases hospital. On examination the child is in severe condition, skin and
mucosa are dry tissue turgor is reduced. The patient's history states that profuse
diarrhea and recurrent vomiting were observed throughout the previous day after the
child had eaten food products of poor quality. What type of salt and water imbalance is
likely to have developed in the patient?
Hypoosmolar dehydration
B. Isoosmolar hyperhydration
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C.Hyperosmolar hyperhydration
D. Isoosmolar dehydration
E Hypoosmolar hyperhydration
A patient presents with steatorrhea, His disorder can be linked to disturbed supply of the
intestine with the following substances
A. Tripsin
B. Amylase
Chymotrypsin
. Bile acids
E. Carbohydrates
132. An 18-year-old student presents with enlarged thyroid gland accompanied by
accelerated metabolism and increased heart rate. These signs can be observed during
hypersecretion of thyroxin. What organelles of thyroid cells are primarily responsible for
hormone production and secretion?
A. Centrosomes
B. Ribosomes
C. Mitochondria
D. Lysosomes
E. Golgi apparatus
135 Due to a case of diphtheria, preventive immunization of the whole contact group of
students is necessary What preparation should be used to produce artificial active
immunity?
A. DTP vaccine
B. Anti-diphtheria serum
C. Specific immunoglobulin
D. Inactivated vaccine
F Diphtheria anatoxin
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134. Poisoning caused by botulinum toxin that prevents calcium ions from entering axon
nerve endings of motoneurons is life-threatening because it can lead to:
A. Respiratory arrest
B. Vomiting
C. Vasotonic disorder
e Cardiac arrest
E. Diarrhea
135 A patient complains of acute increase in diuresis (up to 5-7 liters of urine per 24
hours). Examination revealed decreased secretion of vasopressin in this patient. What
cells have insufficient secretory activity in this case?
Neurosecretory cells of the hypothalamus
B. Pars tuberalis cells
Endocrinocytes of the anterior pituitary.
D. Endocrinocytes of the intermediate pituitary
E. Pituicytes
A 45-year-old woman suffers set arterial hypertension with high blood concentration of
angiotensin II. What antihypertensive drug is the most recommended in the given case?
A. Verapamil
B. Prazosin
Anaprilin (Propranolol)
D. Metoprolol
Lisinopril
A histological specimen demonstrates a vessel with the wall that consists of
endothelium, basement membrane, and loose connective tissue. This vessel belongs to
the following type:
Non-muscular vein
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B. Muscular vein
C. Lymph capillary
D. Hemocapillary
E. Artery
138. A patient presents with increased thickness of alveolar-capillary membrane caused
by a pathologic process. The direct consequence will be the reduction of the following
value:
A. Expiratory reserve volume
B. Respiratory minute volume
Diffusing lung capacity
D. Alveolar ventilation of lungs
E Oxygen capacity of blood
129.A 52-year-old man presents with fever and pain in the joints. Both of his first
metatarsophalangeal articulations are deformed, swollen, and reddened. Blood urea is
high. The patient is diagnosed with gout. What is the main developmental factor in the
pathogenesis of this disease?
A. Citrullinuria
B. Hyperaminoacidemia
C Hyperazotemia
J. Hyperuricemy
E Argininosuccinic aciduria
140] A patient with signs of intestinal infection (vomiting, diarrhea, abdominal pain) has
been presenting with increasing signs of intoxication for three days. Papular rash
appeared on the uncovered skin areas and spread to the torso. A doctor suspects
pseudotuberculosis. What laboratory test allows confirming this diagnosis within the first
week after the onset of disease?
A. Biological
B. Microscopic
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C. Allergic
B. Bacteriological
E. Serological
141. A patient has cardiac rhythm disturbance. ECG shows heart rate of 60/min.,
prolongation of PQ interval periodical loss of QRS complex. What cardiac rhythm
disturbance is it?
A. sick sinus syndrome
B. second-degree incomplete AV block
C. Complete AV block
D. First-degree incomplete AV block
E.His right bundle branch block
A shepherd, who tended to the Hock of sheep with his dogs, gradually developed pain
in the chest and bloody expectorations. X-ray revealed spheric helminth larvae in the
patient's lungs, Specify the helminth that could be the causative agent of this disease:
A. Fasciola hepatica
B. Echinococcus
C. Hymenolepis nana
D. Taenia solium
E. Diphylobotrium latum
A lab rat has subcutaneously received mercury(II) chloride in the amount of 5 mg/kg. 24
hours later the plasma creatinine concentration increased several times. What
mechanism of retention azotemia is observed in this case?
A. Increased creatinine reabsorption
B. Decreased glomerular filtration
C. Increased creatinine production in the renal tubules
D. Increased creatinine production in the muscles
E. Increased glomerular filtration
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144. A 4-year-old child died of cardiopulmonary failure. Autopsy shows dense pancreas,
there are obturative atelectasis and bronchiectasis in the bronchi and fatty liver
infiltration, Microscopy of the pancreas shows cystically dilated ducts, atrophy of the
glandular parenchyma, diffuse fibrosis, and lymphohistiocytic infiltration. What is the
most likely diagnosis?
A. Gametopathy
B. Fetal mucoviscidosis
C. Fetopathy
D. Embryopathy
E. Hirschsprung disease
145. The cells of these living organisms have no membranous organelles and their
genetic material has no nucleus organization. Name these living organisms
A. Protozoa
B. Prokaryotes
C. Eukaryotes
D. Ascomycetes
E Viruses
(146) Due to destruction of certain Structures of the brainstem an animal has lost its
orientation reflexes in response to strong light stimuli. What structures were destroyed?
A. Substantia nigra
B. Red nuclei
C. Vestibular nuclei
J. Anterior quadrigeminal bodies
E. Posterior quadrigeminal bodies
A patient has problems with peripheral circulation, because of limited arterial blood
supply. The affected area is pale and its local temperature is low. This condition is
caused by:
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A, Venous hyperemia
8. Blood "sludge phenomenon
C. lymphocytosis
W. Arterial hyperemia
E. ischemia
148. Hematologic study shows the Following pattern: erythrocytes 2.8 1012/L, Hb - 80
g/L, color index - 0.85. reticulocytes - 0.1%, platelets – 160 thousand per microliter,
leukocytes 60 · 10°/L. Basocytes 2%, eosinophils 8%, promyelocytes - 5%, myelocytes
- 5%, juvenile - 16%, stab neutrophils 20%, segmented neutrophils - 34%, lymphocytes
5%, monocytes - 5%. This clinical presentation indicates the following blood pathology:
A. Chronic myeloleukemia
B. Hemolytic anemia
C. Undifferentiated leukemia
D. Acute myeloleukemia
E. Hypoplastic anemia
149 Patients with hereditary defect of heme-synthesizing enzymes have red urine and
skin that is very sensitive to sunlight. What hemoglobin metabolites accumulate in these
patients, causing these signs?
4. Porphyrinogens
B. Bilirubin
C. Mesobilinogens
D. Stercobilinogens
E_Urobilinogens
150.Investigation of an isolated cardiac myocyte determined that it does not generate
excitation impulses automatically, which means this cardiac myocyte was obtained from
the following cardiac structure:
A. His' bundle
B. Ventricles
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C. Purkinje's fibers
D. Sinoatrial node
E. Atrioventricular node
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