Lesson Plan Course Title: Concepts of Engineering and Technology Session Title: Biotechnology: Science, Technology, and Ethics Performance Objective: After completing this lesson, students will demonstrate they have a broad understanding of the field of biotechnology by completing the biotechnology quiz. Specific Objectives: The student will be able to: Define and describe biotechnology Recall historical and important events involving biotechnology Identify occupations in the biotechnology industry Describe the importance of biotechnology to improvements in the quality of life Evaluate moral and ethical issues involving biotechnology Apply higher order thinking and analysis skills to defend a controversial position Preparation TEKS Correlations: This lesson, as published, correlates to the following TEKS. Any changes/alterations to the activities may result in the elimination of any or all of the TEKS listed. Concepts of Engineering and Technology: 130.362 (c)(7)(A)(B)(C)(D)(E) ...describe the fields of biotechnology; ...describe career opportunities in biotechnology; ...apply design concepts to problems in biotechnology; ...identify fields related to biotechnology; and ...identify currently emerging issues in biotechnology. Interdisciplinary Correlations: Biology: 112.34 (c)(3)(A)(B)(C)(D)(E)(F) ...in all fields of science, analyze, evaluate, and critique scientific explanations by using empirical evidence, logical reasoning, and experimental and observational testing, including examining all sides of scientific evidence of those scientific explanations, so as to encourage critical thinking by the student; ...communicate and apply scientific information extracted from various sources such as current events, news reports, published journal articles, and marketing materials; ...draw inferences based on data related to promotional materials for products and services; Copyright © Texas Education Agency, 2012. All rights reserved. 1 ...evaluate the impact of scientific research on society and the environment; ...evaluate models according to their limitations in representing biological objects or events; and ...research and describe the history of biology and contributions of scientists. 112.34 (c)(5)(D) ...recognize that disruptions of the cell cycle lead to diseases such as cancer. 112.34 (c)(6)(B)(D)(E) ...recognize that components that make up the genetic code are common to all organisms; ...recognize that gene expression is a regulated process; ...identify and illustrate changes in DNA and evaluate the significance of these changes; English: 110.44 (b)(6)(A)(B) …expand vocabulary through wide reading, listening and discussing; …rely on context to determine meanings of words and phrases such as figurative language, connotation and denotation of words, analogies, idioms, and technical vocabulary. 110.44 (b)(7)(H)(I) …use study strategies such as note taking, outlining, and using study-guide questions to better understand texts; …read silently with comprehension for a sustained period time. Teacher Preparation: Review this lesson plan and biotechnology PowerPoint presentation; and perform some background research using internet resources, including those given in the lesson plan. Because of the ethical and moral issues involved in biotechnology, this material is particularly well suited to independent or team based student research. References: Daugherty, E. (2006). Biotechnology: Science for the New Millennium. EMC Publishing. Instructional Aids: 1. Biotechnology PowerPoint presentation 2. Domestic Animals PowerPoint (3 slides) 3. http://bio.org/news/publications/ 4. http://bio.org/speeches/pubs/er/BiotechGuide2008.pdf 5. Definitions, Key Figures, and Major Historical Developments handout for each student 6. Biotechnology quiz and quiz key Materials Needed: 1. Any cereal product (actual or picture) 2. A picture(s) of domesticated animal(s) Copyright © Texas Education Agency, 2012. All rights reserved. 2 3. Technical Report and Presentation Rubric for each student Equipment Needed: 1. Computer with internet access 2. Projector Learner Preparation: None required. Introduction Introduction (LSI Quadrant I): SAY: Today we are going to be talking about one of the most important fields of technology that exists. Historically, biotechnology primarily involved the food we eat, but more recently biotechnology involves our health and health care. ASK: Does anyone know how long biotechnology has existed? SAY: 10,000 years SHOW: Any cereal product. SAY: This is a product that is the result of biotechnology. ASK: Can anyone tell me how many different elements of biotechnology went into the development of this product? SAY: Crop selection, pesticide and fertilizers, vitamin and mineral enrichment, even genetic engineering through DNA manipulation. SHOW: A picture of any domestic animal (dog, horse, cow, etc). ASK: Historically, how have we performed biotechnology on this animal? SAY: Breeding. ASK: How do we perform biotechnology today? SAY: Cloning, genetic engineering. Outline Outline (LSI Quadrant II): Instructors can use the PowerPoint presentation, slides, handouts, and note pages in conjunction with the following outline. MI . Outline I. Start with the definition of biotechnology A. Students should know that some forms of biotechnology have been around for thousands of years B. Current biotechnology is heavily dependent upon laboratory experiments and equipment C. A great resource can be found at http://bio.org/speeches/pubs/er/BiotechG uide2008.pdf Notes to Instructor Begin biotechnology PowerPoint presentation. It is designed to give background and general information; however, the lesson is designed around student research. The intention of the presentation is to prepare the students for their research. Copyright © Texas Education Agency, 2012. All rights reserved. 3 II. History A. Arguably, no field of science has improved global human health more. B. Current biotechnology research and development rely heavily on recombinant DNA. C. Biotechnology fields and categories overlap to some degree, but involve different types of information. D. More than 325 million people worldwide have been helped by the more than 150 biotechnology drugs and vaccines approved by the U.S. Food and Drug Administration.. Slides 3-4 III. Classification of biotechnology A. Fields of study and employment B. Processes involved in research and development C. Categories such as diagnostics or therapies, medical or agricultural Categories: Slides 5-9 V. Ethical and Social Considerations A. There are a number of controversial elements to biotechnology. B. There are often no definitive answers to some of the controversy. C. There are a huge number of Internetbased sources that look at both sides of an issue. D. The nature of this field is almost Uniquely suited for students to perform individual or team based research. E. Research can lead to a written report or a verbal presentation. Slides 13-16 VI. Assign student research and/or presentation A. Evaluation according to assessment rubric Slides 17-18 History can be amplified and covered in more depth at teacher’s own discretion. The definitions and historical figures handout include a timeline that provides a guide. There are a variety of different ways to classify and categorize all of the different elements of biotechnology. Students should be able to find a field or topic that they find interesting and have an opinion on. Leverage their interest to get them to perform the work involved with researching and analyzing both sides an issue. Distribute Technical Report and Presentation Copyright © Texas Education Agency, 2012. All rights reserved. 4 Rubric to each student. (Teacher may modify the assessment rubric provided with this lesson as needed.) Verbal Linguistic Logical Mathematical Visual Spatial Musical Rhythmic Bodily Kinesthetic Intrapersonal Interpersonal Naturalist Existentialist Application Guided Practice (LSI Quadrant III): Use the biotechnology PowerPoint presentation to introduce some of the ways to categorize and classify different elements to the broad field of biotechnology. Then use the historical overview given in pages 6 through 14 of the BioTech guide: (http://bio.org/speeches/pubs/er/BiotechGuide2008.pdf) and ask students to place the developments into one or more of the categories. Independent Practice (LSI Quadrant III): Independent practice will primarily involve individual or team-based student research, but can also involve reviewing the handout on definitions, key figures, and major historical breakthroughs. Summary Review (LSI Quadrants I and IV): Question: What is the major focus of biotechnology today? Answer: Manipulation of DNA through genetic engineering. Question: What is the difference between diagnostics and therapy? Answer: Diagnostics tests for the presence or absence of a disorder, therapy treats the disorder. Question: What are the two categories of agricultural biotechnology? Answer: Crops and livestock. (These can be further subdivided.) Question: What are two other types of technology that are used to develop and improve biotechnology? Answer: Microelectronic technology and nanotechnology. (There can be other answers.) Evaluation Copyright © Texas Education Agency, 2012. All rights reserved. 5 Informal Assessment (LSI Quadrant III): Notes and definitions that are assigned as board work can be graded. As students perform research, give grades for milestones or stages of completion. Formal Assessment (LSI Quadrant III, IV): Quiz based on definitions, key figures, and major historical breakthroughs. The research paper or presentation will be the major component of formal assessment. Quality of research and presentation will be assessed with Technical Report and Presentation Rubric. Extension Extension/Enrichment (LSI Quadrant IV): Have a student do in depth research on any one of a variety of topics: labeling bio engineered foods, genetically modified foods, cloning, patenting DNA, what is DNA, recombinant DNA, methods to treat cancer or HIV. You can have a student pick (or be assigned) any one of dozens of historical figures and people who have made important contributions to biotechnology to perform in depth research. You can have students research the various fields involved in biotechnology, like forensics. Copyright © Texas Education Agency, 2012. All rights reserved. 6 Biotechnology Definitions, Key Figures, and Major Historical Developments Definitions: Autoimmune disorders - A condition which occurs when the immune system mistakenly attacks and destroys healthy body tissue. Biotechnology - The application of technology to the study or manipulation of living things. Chemical bases - Adenine (A), Guanine (G), Cytosine (C) and Thymine (T). The genes that make up your body by stringing together to form DNA. Cloning - To generate a population of genetically identical molecules, cells, plants or animals. Diamond vs. Chakrabarty - A United States Supreme Court case dealing with whether genetically modified organisms can be patented. DNA (deoxyribonucleic acid) - The genetic material of most living organisms. DNA fingerprinting - A test to identify and evaluate the genetic information called DNA in a person's cells. Fermentation - The anaerobic conversion of sugar to carbon dioxide and alcohol by yeast. Genes - A region of DNA that controls a hereditary characteristic. Genetics - The branch of biology that deals with heredity, especially the mechanisms of hereditary transmission and the variation of inherited characteristics among similar or related organisms. Genetic engineering - A laboratory technique used by scientists to change the DNA of living organisms. Gene therapy - A technique for correcting defective genes responsible for disease development. Human genome map - The finished sequence of the human genome. Human Genome Project - An international scientific research project with a primary goal to determine the sequence of chemical base pairs which make up DNA and to identify and map the approximately 20,000–25,000 genes of the human genome from both a physical and functional standpoint. Copyright © Texas Education Agency, 2012. All rights reserved. 7 Immunology - The study of our protection from foreign macromolecules or invading organisms and our body’s responses to them. Interferon - A naturally occurring substance that interferes with the ability of viruses to reproduce. Molecular biology - The study of biology at a molecular level. It chiefly concerns itself with understanding the interactions between the various systems of a cell. Nucleotide - A nucleotide is the monomer structural unit of nucleotide chains that form the nucleic acids RNA and DNA; in other words, the building blocks for DNA and RNA. Proteins - Any of a group of complex organic macromolecules that are composed of one or more chains of amino acids. Recombinant DNA - The joining — or recombining — of two pieces of DNA from different sources, such as from two different organisms. RNA (ribonucleic acid) - One of the two main types of nucleic acid (the other being DNA), that consists of strands of repeating nucleotides joined in chainlike fashion, but the strands are single (except in certain viruses), and it has the nucleotide uracil (U) where DNA has thymine (T). Somatic cell nuclear transfer - Or therapeutic cloning involves removing the nucleus of an unfertilized egg cell, replacing it with the material from the nucleus of a "somatic cell" (a skin, heart, or nerve cell, for example), and stimulating this cell to begin dividing. Stem cells - A class of undifferentiated cells that are able to differentiate into specialized cell types. Thalidomide - introduced as a sedative drug in the late 1950s, then banned in the early 1960s after it was found to cause deformed limbs in the children of women who took it early in pregnancy. Transgenic - An organism whose genetic material has been altered using genetic engineering techniques. Xenotransplantation - The transplantation of living cells, tissues or organs from one species to another, such as from pigs to humans. Copyright © Texas Education Agency, 2012. All rights reserved. 8 Key Figures: Stanley Cohen and Herbert Boyer invented the technique of DNA cloning, which allowed genes to be transplanted between different biological species. Their discovery signaled the birth of genetic engineering. Robert Hooke developed inventions including the spring control of the balance wheel in watches, and the first reflecting telescope. The first to apply the word "cell" to describe the basic unit of life. Edward Jenner discovered in 1796 that inoculation with cowpox gave immunity to smallpox, an immense medical breakthrough that has saved countless lives. Louis Pasteur invented pasteurization and discovered the germ theory of disease. William James Beal was one of the pioneers in the development of hybrid corn. Walther Flemming developed a new staining technique in 1879, using synthesized aniline dyes to identify chromosomes, the structures of the cell nucleus. This allowed observation of mitosis, a term first used by Flemming for cell division. George Washington Carver worked on improving soils, growing crops with low inputs, and using species that fixed nitrogen as alternative crops to cotton. Peyton Rous was involved in the discovery of the role of viruses in the transmission of certain types of cancer. Alexander Fleming was the bacteriologist who discovered penicillin. Henry Wallace experimented with breeding high-yielding strains of corn (maize), and developed a breed of chicken that at one point accounted for the overwhelming majority of all egg-laying chickens sold across the globe. Oswald Avery proved that DNA — not protein, as many believed at the time — is the agent of heredity. Linus Pauling is the only person who has won two undivided Nobel Prizes, studied and published papers on the effects of certain blood cell abnormalities, the relationship between molecular abnormality and heredity, the possible chemical basis of mental retardation, and the functioning of anesthetics. James Watson and Francis Crick were discoverers of the DNA molecular structure. Norman Borlaug helped to develop the high-yield, low-pesticide dwarf wheat upon which a substantial portion of the world's population now depends for sustenance. Copyright © Texas Education Agency, 2012. All rights reserved. 9 Paul Berg performed pioneering work involving recombinant DNA, leading to the development of modern genetic engineering. Kary Mullis received the Nobel Prize for his development of the Polymerase Chain Reaction (PCR), a process that allows the amplification of specific DNA sequences. Richard Lower was concerned principally with two areas of investigation: transfusion and cardiopulmonary function. Rachel Carson is author of Silent Spring, and credited with advancing the global environmental movement. Major Historical Developments: Antiquity: Humans domesticate crops and livestock. 4000–2000 B.C. ●● Biotechnology is first used to leaven bread and ferment beer with yeast (Egypt). ●● Production of cheese and fermentation of wine begin. 1590–1608 ●● The compound microscope is invented in the Netherlands. 1663 ●● English physicist Robert Hooke discovers existence of the cell. 1675 ●● Dutch scientist Antonie van Leeuwenhoek discovers bacteria. 1830–1833 ●● 1830 — Proteins are discovered. ●● 1833 — First enzyme is discovered and isolated. 1911 ●● American pathologist Peyton Rous discovers the first cancer causing virus. 1914 ●● Bacteria are used to treat sewage for the first time in Manchester, England. 1944 Canadian-born American bacteriologist Oswald Avery and colleagues discover that DNA carries genetic information. Copyright © Texas Education Agency, 2012. All rights reserved. 10 1946 ●● Scientists discover that genetic material from different viruses can be combined to form a new type of virus, an example of genetic recombination. 1953 ●● The scientific journal Nature publishes James Watson and Francis Crick’s manuscript describing the double helical structure of DNA, which marks the beginning of the modern era of genetics. The 1950s ●● Interferons are discovered. ●● The first synthetic antibiotic is created. 1963 ●●New wheat varieties developed by American agricultural scientist Norman Borlaug increase yields by 70 percent. 1966 ●● The genetic code is cracked, demonstrating that a sequence of three nucleotide bases (a codon) determines each of 20 amino acids. (Two more amino acids have since been discovered.) 1972 ●● American biochemist Paul Berg publishes the results of his work creating the first DNA molecules that combine genes from different organisms. 1976 ●● The tools of recombinant DNA (rDNA) are first applied to a human inherited disorder. 1978 ●● Recombinant human insulin is first produced. 1980 ●● The U.S. Supreme Court, in the landmark case Diamond v. Chakrabarty, approves the principle of patenting organisms, which allows the Exxon oil company to patent an oil-eating microorganism. ●● The U.S. patent for gene cloning is awarded to American biochemists Stanley Cohen and Herbert Boyer. 1982 ●● The first biotech drug is approved by FDA: human insulin produced in genetically modified bacteria. 1984 ●● The DNA fingerprinting technique (using PCR) is developed. Copyright © Texas Education Agency, 2012. All rights reserved. 11 1986 ●● The first recombinant vaccine for humans is approved, a vaccine for hepatitis B. ●● Interferon becomes the first anticancer drug produced through biotech. 1987 ●● The first field test for a biotech crop — virus-resistant tomatoes — is approved. ●● Frostban, a genetically altered bacterium that inhibits frost formation on crop plants, is field-tested on strawberry and potato plants in California, the first authorized outdoor tests of a recombinant bacterium. 1990 ●● Chy- Max™, an artificially produced form of the chymosin enzyme for cheesemaking, is introduced. It is the first product of recombinant DNA technology in the U.S. food supply. ●● The Human Genome Project — an international effort to map all the genes in the human body — is launched. ●● The first experimental gene therapy treatment is performed successfully on a 4-yearold girl suffering from an immune disorder. ●● The first transgenic dairy cow — used to produce human milk proteins for infant formula — is created. ●● The first insect-protected biotech corn is produced: Bt corn. ●● The first food product of biotechnology is approved in U.K.: modified yeast. 1994 ●● FDA approves the first whole food produced through biotechnology: FLAVRSAVR™ tomato. ●● The first breast-cancer gene is discovered. 1997 ●●Dolly the sheep is unveiled in Scotland as the first animal cloned from an adult cell. 1998 ●●Human embryonic stem cell lines are established. ●● The FDA approves the breast cancer drug Herceptin® (trastuzumab) for patients whose cancer overexpresses the HER2 receptor. It is widely considered the first pharmacogenomic (or personalized) medicine. ●● An early rough draft of the human genome map is produced, showing the locations of thousands of genes. 2000 ●● A rough draft of the human genome sequence is announced. Copyright © Texas Education Agency, 2012. All rights reserved. 12 Biotechnology Quiz 1. Biotechnology is the application of technology to the study or manipulation of a. b. c. d. 2. How long has mankind been performing biotechnology? a. b. c. d. 3. DNA fingerprinting Medical diagnostics Bioremediation Cloning Pharmaceuticals fall into which category of biotechnology? a. b. c. d. 6. Discovery of cells A new recombinant DNA technique Genetic engineering Crop and animal breeding Which of the following is an example of forensics? a. b. c. d. 5. 6,000 years 2,000 years 200 years 40 years What was the key to the emergence of the biotechnology industry in the 1900s? a. b. c. d. 4. Plants Animals Living things People Diagnostics Therapeutics Agriculture Bioremediation Decreasing pesticide applications falls into which category of biotechnology? a. b. c. d. Diagnostics Therapeutics Agriculture Bioremediation Copyright © Texas Education Agency, 2012. All rights reserved. 13 7. Which of the following is NOT a biotechnology procedure? a. b. c. d. 8. Which of the following is performed by a bioindustry supplier? a. b. c. d. 9. Animals have feelings Animals have the same rights as humans Experts are reliable and impartial Concern about environmental consequences Which of the following would be characteristic of a biomedical researcher? a. b. c. d. 12. Gene isolation Gene modification Basic molecular biology Develop transgenes Which of the following would be characteristic of an animal rights activist? a. b. c. d. 11. Specialized software development Creating new sources of energy Treatment of cancer Perform genetic engineering Which of the following is NOT an example of genetic engineering? a. b. c. d. 10. Production of human insulin Cultivation of microorganisms Fermentation Development of technical instruments Animals don’t have feelings Animals have no rights Experts are reliable and impartial No concern about environmental consequences Which of the following is an example of xenotransplantation? a. b. c. d. Kidney donation from a father to a son Using stem cells to treat cancer Cloning a pet Using a pig heart valve to treat heart disease Copyright © Texas Education Agency, 2012. All rights reserved. 14 13. Which of the following court ruling made DNA patentable? a. b. c. d. 14. Diamond vs. Chakrabarty Brown vs. Board of Education Scopes monkey trial Roe vs. Wade Which of the following needs to be considered from an ethical standpoint? a. b. c. d. Gene isolation Production of human insulin Animal research Products that cure or reduce the incidence of disease 15. Which of the following is a laboratory technique used by scientists to change the DNA of living organisms? a. b. c. d. Molecular biology Genetic engineering Cloning Immunology 16. Which of the following is a class of undifferentiated cells that are able to differentiate into specialized cell types? a. b. c. d. 17. Stem cells Interferon Recombinant DNA Genetics Which of the following is a test to identify and evaluate the genetic information called DNA in a person's cells? a. b. c. d. 18. Genetic engineering DNA fingerprinting Recombinant DNA Immunology What is a gene? a. b. c. d. A region of DNA that controls a hereditary characteristic. The transplantation of living cells, tissues or organs from one species to another, such as from pigs to humans. A naturally occurring substance that interferes with the ability of viruses to reproduce. An organism whose genetic material has been altered using genetic engineering techniques. Copyright © Texas Education Agency, 2012. All rights reserved. 15 19. Who discovered the DNA molecular structure? a. b. c. d. George Washington Carver Louis Pasteur James Watson and Francis Crick Linus Pauling 20. Who was the only person who has won two undivided Nobel Prizes? a. b. c. d. George Washington Carver Louis Pasteur James Watson and Francis Crick Linus Pauling 21. List several biotechnology fields. 22. What is bioremediation? 23. Why do we use animals in biotechnology research? 24. Where do we use fermentation? 25. Describe ethical analysis. Copyright © Texas Education Agency, 2012. All rights reserved. 16 Biotechnology Quiz Key 1. Biotechnology is the application of technology to the study or manipulation of a. b. c. d. 2. How long has mankind been performing biotechnology? a. b. c. d. 3. DNA fingerprinting Medical diagnostics Bioremediation Cloning Pharmaceuticals fall into which category of biotechnology? a. b. c. d. 6. Discovery of cells A new recombinant DNA technique Genetic engineering Crop and animal breeding Which of the following is an example of forensics? a. b. c. d. 5. 6,000 years 2,000 years 200 years 40 years What was the key to the emergence of the biotechnology industry in the 1900’s? a. b. c. d. 4. Plants Animals Living things People Diagnostics Therapeutics Agriculture Bioremediation Decreasing pesticide applications falls into which category of biotechnology? a. b. c. d. Diagnostics Therapeutics Agriculture Bioremediation Copyright © Texas Education Agency, 2012. All rights reserved. 17 7. Which of the following is NOT a biotechnology procedure? a. b. c. d. 8. Which of the following is performed by a bioindustry supplier? a. b. c. d. 9. Animals have feelings Animals have the same rights as humans Experts are reliable and impartial Concern about environmental consequences Which of the following would be characteristic of a biomedical researcher? a. b. c. d. 12. Gene isolation Gene modification Basic molecular biology Develop transgenes Which of the following would be characteristic of an animal rights activist? a. b. c. d. 11. Specialized software development Creating new sources of energy Treatment of cancer Perform genetic engineering Which of the following is NOT an example of genetic engineering? a. b. c. d. 10. Production of human insulin Cultivation of microorganisms Fermentation Development of technical instruments Animals don’t have feelings Animals have no rights Experts are reliable and impartial No concern about environmental consequences Which of the following is an example of xenotransplantation? a. b. c. d. Kidney donation from a father to a son Using stem cells to treat cancer Cloning a pet Using a pig heart valve to treat heart disease Copyright © Texas Education Agency, 2012. All rights reserved. 18 13. Which of the following court ruling made DNA patentable? a. b. c. d. 14. Diamond vs. Chakrabarty Brown vs. Board of Education Scopes monkey trial Roe vs. Wade Which of the following needs to be considered from an ethical standpoint? a. b. c. d. Gene isolation Production of human insulin Animal research Products that cure or reduce the incidence of disease 15. Which of the following is a laboratory technique used by scientists to change the DNA of living organisms? a. b. c. d. Molecular biology Genetic engineering Cloning Immunology 16. Which of the following is a class of undifferentiated cells that are able to differentiate into specialized cell types? a. b. c. d. Stem cells Interferon Recombinant DNA Genetics 17. Which of the following is a test to identify and evaluate the genetic information called DNA in a person's cells? a. b. c. d. Genetic engineering DNA fingerprinting Recombinant DNA Immunology Copyright © Texas Education Agency, 2012. All rights reserved. 19 18. What is a gene? a. b. c. d. A region of DNA that controls a hereditary characteristic. The transplantation of living cells, tissues or organs from one species to another, such as from pigs to humans. A naturally occurring substance that interferes with the ability of viruses to reproduce. An organism whose genetic material has been altered using genetic engineering techniques. 19. Who discovered the DNA molecular structure? a. b. c. d. George Washington Carver Louis Pasteur James Watson and Francis Crick Linus Pauling 20. Who was the only person who has won two undivided Nobel Prizes? a. b. c. d. George Washington Carver Louis Pasteur James Watson and Francis Crick Linus Pauling 21. List several biotechnology fields. Genetic engineering Environmental technology Ecology and environmental problems Bioremediation Crop and animal breeding Medicine Diagnostics Pharmaceuticals Nutrition Forensics 22. What is bioremediation? It involves using biotechnology-designed organisms to clean up oil or other spills. Copyright © Texas Education Agency, 2012. All rights reserved. 20 23. Why do we use animals in biotechnology research? Animals are biologically similar to humans. They are susceptible to many of the same health problems, and they have short life-cycles so they can easily be studied throughout their whole life-span or across several generations. In addition, scientists can easily control the environment around the animal (diet, temperature, lighting, etc.), which would be difficult to do with people. However, the most important reason why animals are used is that it would be wrong to deliberately expose human beings to health risks in order to observe the course of a disease. 24. Where do we use fermentation? We use fermentation in brewing, baking, and cheese production. 25. Describe ethical analysis. 1. Formulation of the dilemma; 2. Finding out the possible options of action in this situation; 3. Assignment of the optional actions to values that are touched by the action and reflection of the consequences; 4. Taking a justified decision for one of the options of action in respect to the reflections in step 3; 5. Assignment of the decision taken to one of the two higher categories of argumentation; 6. Description and discussion of the consequences of the decision taken in step 4 for the individual and for the society. Copyright © Texas Education Agency, 2012. All rights reserved. 21 Technical Report and Presentation Rubric Item Issue Writing Overall effectiveness of communication Wgt Exceptional (3) Acceptable (2) Marginal (1) Unacceptable (0) The writer’s decisions about focus, organization, style/tone, and content made reading a pleasurable experience. Writing could be used as a model of how to fulfill the assignment. The purpose and focus of the writing are clear to the reader and the organization and content achieve the purpose well. Writing follows all requirements for the assignment. The writer has made good decisions about focus, organization, style/tone, and content to communicate clearly and effectively. The purpose and focus of the writing are clear to the reader and the organization and content achieve the purpose well. Writing follows all requirements for the assignment. The writer’s decisions about focus, organization, style/tone, and/or content sometimes interfere with clear, effective communication. The purpose of the writing is not fully achieved. All requirements of the assignment may not be fulfilled. The writer’s decisions about focus, organization, style/tone, and/or content interfere with communication. The purpose of the writing is not achieved. Requirements of the assignment have not been fulfilled. Writing flows smoothly from one idea to another. Evidence of analysis, reflection and insight. Sequencing of ideas within paragraphs and transitions between paragraphs make the writer’s points easy to follow. Sentences are structured and words are chosen to communicate ideas clearly. Some idea development supported by relevant details. Transitions between paragraphs make the writer’s points easy to follow. Sentence structure and/or word choice sometimes interfere with clarity. Idea development and sequencing between paragraphs need improvement. Unelaborated and/or repetitious details. Sentence structure, word choice, lack of transitions and/or sequencing of ideas make reading and understanding difficult. Minimal idea development, limited and/or unrelated details. Demonstration of full knowledge of the subject with explanations and elaboration. Writer is at ease with content and able to elaborate and explain to some degree. Writer is uncomfortable with content. Only basic concepts are demonstrated and interpreted. No grasp of required subject matter. No understanding of major issues. No interpretation of results. Information is presented in a logical, interesting way, which is easy to follow. Organizes material in a clear, appropriate, and precise manner. Information is presented in a logical manner, which is easily followed. Organizes material in an appropriate manner. Work is hard to follow as there is very little continuity. Some evidence of a cohesive plan. Sequence of information is difficult to follow. No apparent structure or continuity. Little evidence of a cohesive plan. 2 Negligible errors. Effective editing and revisions improve overall quality of work. Minor errors. Much evidence of revision and editing. Several errors. Some evidence of Numerous errors. Little revision and editing. evidence of revision or editing. 3 Correct interpretation of data or information. Analysis and conclusion are based on research. Correctly interprets data or information, but analysis or conclusion may not be supported by research. Correctly interprets data or information but provides little or no evidence of analysis or conclusion. Research is limited. Incorrectly interprets data or information with little or no analysis or conclusion. Little or no evidence of research presented. Report was free of “noise issues.” Describes all examples with detail and clarity. Articulates appropriate vocabulary and terms associated with the subject matter. Some instances of “noise.” Describes some examples with detail and clarity. Articulates appropriate vocabulary but is still limited somewhat. Many instances of “noise.” Describes simple examples with little detail. Some inappropriate vocabulary present, or limited use of appropriate vocabulary. Report plagued with distractions and ‘noise.” Has trouble describing examples used to support the adjectives. Inappropriate vocabulary use occurs. 5 Writing Writing process 4 Writing Organization Mechanics Research Readability Demonstration of knowledge Flow of information Spelling and Grammar Research and Interpretation of Data 4 2 Clarity of writing 2 Copyright © Texas Education Agency, 2012. All rights reserved. Points 22 References References Reference section complete, comprehensive and follows required format. Minor inadequacies in references or inconsistencies in format. Inadequate list of references or failure to follow required format. No referencing system used. Exceptional (A-Level) Acceptable (B-C Level) Marginal (C-D Level) Unacceptable (D-F Level) Exceptional (3) Acceptable (2) Marginal (1) Unacceptable (0) Poised, clear articulation; proper volume; steady rate; enthusiasm; confidence. Presenter is clearly comfortable in front of the group. Correct, precise pronunciation of terms. Selects rich and varied words for context and uses correct grammar. Clear articulation but not as polished. Presenter slightly uncomfortable at times. Most can hear presentation. Pronounces most words correctly. Selects words appropriate for context and uses correct grammar. Audience occasionally has trouble hearing the presentation. Presenter seems uncomfortable. Sometimes incorrectly pronounces terms. Selects words inappropriate for context; uses incorrect grammar. Presenter is obviously anxious and cannot be heard or is monotone with little or no expression. Student mumbles, pronounces words incorrectly. Selects words inappropriate for context; Uses incorrect grammar. Graphics are designed, reinforce presentation thesis and maximize audience understanding; use of media is varied and appropriate, with media not being added simply for the sake of use. Visual aids were colorful and large enough to be seen by all, even those in back of the class. Media are prepared in a professional manner. Details are minimized so that main points stand out. While graphics relate and aid presentation thesis, these media are not as varied and not as well connected to presentation thesis. Font size is appropriate for reading. Appropriate information is prepared. Some material is not supported by visual aids. Occasional use of graphics that rarely support presentation thesis; visual aids were not colorful or clear. Choppy, time wasting use of multimedia; lacks smooth transition from one medium to another. Font is too small to be easily seen. Communication aids are poorly prepared or used inappropriately. Too much information is included. Unimportant material is highlighted. Student uses superfluous graphics, no graphics, or graphics that are so poorly prepared that they detract from the presentation. 4 Encourages audience interaction. Calls on classmates by name. Involved the audience in the presentation; held the audience's attention throughout. Demonstrates extensive knowledge of the topic by responding confidently, precisely and appropriately to all audience questions. Maintains eye contact; seldom returning to notes; presentation is like a planned conversation. Encourages audience interaction. Held the audience's attention most of the time. Demonstrates knowledge of the topic by responding accurately and appropriately addressing questions. At ease with answers to all questions but fails to elaborate. Student maintains eye contact most of the time but frequently returns to notes. Reluctantly interacts with audience. Goes off topic. Demonstrates some knowledge of topic in response to questions. Some eye contact, but not maintained, and at least half the time reads report. Avoids or discourages active audience participation. Audience lost interest. Demonstrates incomplete knowledge of the topic by responding inaccurately and inappropriately to questions. Student reads all or most of report with no eye contact. 2 Introduces the purpose of the presentation clearly and creatively. Student presents information in logical, interesting sequence which audience can follow. Ends with an accurate conclusion showing thoughtful, strong Introduces the purpose of the presentation clearly. Most information presented in logical sequence. A few minor points may be confusing. Ends with a summary of main points showing some Introduces the purpose of the presentation. Student jumps around topics. Several points are confusing. Ends with a summary or conclusion; little evaluation of content based on evidence. Does not clearly introduce the purpose of the presentation. Presentation is choppy and disjointed; no apparent logical order of presentation. Ends without a 1 Overall Performance Item Issue Wgt Overall effectiveness of presentation Presentation 5 Media and graphics Presentation 4 Audience interaction Presentation Flow of information Organization Copyright © Texas Education Agency, 2012. All rights reserved. TOTAL Points Font is too small to be easily seen. 23 Mechanics Presentation Overall Performance 2 evaluation of the evidence presented. evaluation of the evidence presented. summary or conclusion. Level of presentation is appropriate for the audience. Personal appearance is completely appropriate for the occasion and the audience. Within 1 minute of allotted time. Level of presentation is generally appropriate. For the most part, personal appearance is appropriate for the occasion and the audience. Within 3 minutes of allotted time Portions of presentation are too elementary or too sophisticated for audience. Personal appearance is somewhat inappropriate for the occasion and audience. Within 5 minutes of allotted time Presentation consistently is too elementary or too sophisticated for the audience. Personal appearance is inappropriate for the occasion. Well outside of allotted time. Exceptional (A-Level) Acceptable (B-C Level) Marginal (C-D Level) Unacceptable (D-F Level) Copyright © Texas Education Agency, 2012. All rights reserved. TOTAL 24