John C. Yoon, M.D., Ph.D.
Clinical Interests
Research/Academic Interests
Dr. Yoon's clinical interests are in Diabetes Mellitus.
Dr. Yoon is interested in molecular studies of metabolic regulation and human disease, with a
particular focus on diabetes mellitus. Ongoing work utilizes a combination of experimental
systems and approaches to investigate the role of specific intracellular signaling pathways such as
the Wnt pathway in the regulation of muscle metabolism and their impact on physiological and
pathological adaptations.
Another area of interest is the contribution of mitochondrial defects and inflammatory processes to
the development of metabolic disease. Large-scale genetic screens in muscle cells have been
performed to isolate regulators of mitochondrial function and some of the identified genes are
being characterized.
Title
Specialty
Department
Assistant Professor
Endocrinology, Diabetes, and Metabolism, Internal Medicine
Internal Medicine
UC Davis Medical Group
Division
Clinic
Center/Program Affiliation
Address/Phone
Endocrinology, Diabetes, and Metabolism
UC Davis Medical Group, Sacramento
UC Davis Medical Group
Lawrence J. Ellison Ambulatory Care Center, Endocrinology, Diabetes & Metabolism Clinic, 4860
Y St. Suite 0400 Sacramento, CA 95817
Phone: 916-734-2737
Additional Phone
Clinic Fax: 916-734-5484
Physician Referrals: 800-4-UCDAVIS (800-482-3284)
Languages
Education
Korean
M.D., Harvard Medical School, Boston MA 2002
Ph.D., Biological Chemistry, Harvard Graduate School, Boston MA 2002
A.B., Harvard University, Cambridge MA 1990
John C. Yoon, M.D., Ph.D.
Internships
Internal Medicine, New York Presbyterian Hospital, New York NY 2002-2003
Residency
Internal Medicine, New York Presbyterian Hospital, New York NY 2003-2004
Fellowships
Genetics, Brigham and Women's Hospital, Boston MA 2007-2009
Endocrinology, Massachusetts General Hospital, Boston MA 2004-2007
Board Certifications
American Board of Internal Medicine
American Board of Internal Medicine, Endocrinology, Diabetes and Metabolism
Honors and Awards
Damon Runyon Cancer Research Foundation Fellow, 2007
Leon Reznick Prize for Excellence in Research, Harvard Medical School, 2002
Select Recent Publications
Yoon JC, Ling AL, Isik M, Lee DD, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair
DA, Elledge SJ. GLTSCR2/PICT-1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci
USA. 2014;111: 3781-3786.
Davoli T, Xu W, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ. Cumulative
haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome.
Cell. 2013;155:948-962.
Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ. Wnt signaling regulates mitochondrial
physiology and insulin sensitivity. Genes Dev. 2010;24:1507-1518.
Puigserver, P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong
H, Accili, and Spiegelman BM. Insulin-Regulated Hepatic Gluconeogenesis through FOXO1-PGC1 Interaction. Nature. 2003;423(6939):550-555.
Yoon JC, Puigserver P, Chen G, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK,
Newgard CB, and Spiegelman BM. Control of Hepatic Gluconeogenesis through the Transcriptional
Coactivator PGC-1. Nature. 2001;413:131-138.
John C. Yoon, M.D., Ph.D.
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