Heather Hill
Department of Chemistry and Biochemistry
University of North Carolina at Wilmington
Wilmington, NC 28403

 Molecules being constructed in our lab:

 This molecule binds in the groove of DNA


Crystal Structure of DNA with molecule
(modified in Titan)

 DNA with molecule and an attached linker and glucose ring (modified in Insight II)

Methods
 Build/model molecules with two different targeting molecules and several different linkers
 Submit for calculations
 Compare to lab results

Benefits of Project
 Save time
 Save money
 Identify possible candidates and eliminate those that do not work

References
 Zhang, Y., Chen, F.-X., Mehta, P., and
Gold, B. (1993) Biochemistry 32, 7954-
7965.
 Varadarajan, S., Dharini, S., Dande, P.,
Settles, S., Chen, F.-X., Gilberto, F., and
Gold, B. (2003) Biochemistry 42,
14318-14327.

Acknowledgements
 Dr. Varadarajan
 Dr. Martin
 Dr. Bartolotti ( East Carolina University)