2012 Publications Total 30 1. The case for treating hypercholesterolemia at an earlier age: Moving toward consensus. Steinberg, D. and Grundy, S.M. J Am Coll Cardiol, 2012. 2. Fasting glucose, obesity, and metabolic syndrome as predictors of type 2 diabetes: The Cooper Center Longitudinal Study. Defina, L.F., Vega, G.L., Leonard, D and Grundy S.M. J Investig Med, 2012 60:1164‐1168. 3. Treatment targets in the management of dyslipidemias: Which targets in whom? Grundy, S.M. Curr Cardiol Rep, 2012 [Epub ahead of print]. 4. Cardiorespiratory fitness, LDL cholesterol, and coronary heart disease mortality in men. Farrell, W.S., Finley, C.E. and Grundy S.M. Med Sci Sports Exerc, 2012 [E pub ahead of print]. 5. Homozygous null mutations in ZMPSTE24 in restrictive dermopathy: evidence of genetic heterogeneity. Ahmad Z, Phadke SR, Arch E, Glass J, Agarwal AK, Garg A. Clin Genet, 2012 81:158‐64. PMID: 21108632. 6. Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis Li Z.J., Huang Y., Karaman R., Ivanova P.T, Brown A.H., Roddy T., Castro‐Perez J., Cohen J.C., and Hobbs H.H. J. Clin. Invest, 2012 122:4130–4144. 7. Atypical angiopoietin‐like protein that regulates ANGPTL3 Quagliarini F., Wang Y., Kozlitina J., Grishin N.V., Hyde R., Boerwinkle E., Valenzuela, D.M., Murphy A.J., Cohen J.C., and Hobbs H.H. Proc. Natl. Acad. Sci., 2012 USA, 109:19751. 8. Influence of upper and lower body adipose tissue on insulin sensitivity in South Asian men. Balakrishnan, P., Grundy, S.M., Islam, A., Dunn, F., Vega, G.L. J Investig Med, 2012 60: 999‐1004. 9. Low prevalence of mutations in known loci for autosomal dominant hypercholesterolemia in a multi‐ethnic patient cohort. Ahmad Z, Adams‐Huet B, Chen C, Garg A. Circ Cardiovasc Genet., 2012 Oct 11. [Epub ahead of print] PMID: 23064986. 10. Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults. Neeland, I.J., Turer, A.T., Ayers, C.R., Rowell‐Wiley, T.M., Vega, G.L., Farzaneh‐Far, R., Grundy, S.M., Khera, A., McGuire, D.K, de Lemos, J.A. JAMA, 2012 308:1150‐1159. 11. Atherogenic low density lipoprotein phenotype in long‐term survivors of childhood acute lymphoblastic leukemia. Malhotra J, Tonorezos ES, Rozenberg M, Vega GL, Sklar CA, Chou J, Moskowitz CS, Eshelman‐Kent DA, Janiszewski P, Ross R, Oeffinger KC. J Lipid Res., 2012 Dec; 53(12):2747‐54. doi: 10.1194/jlr.P029785. Epub 2012 Sep 13. PubMed PMID: 22984143; PubMed Central PMCID: PMC3494249. 12. Molecular characterization of proprotein convertase subtilisin/kexin type 9‐mediated degradation of the LDLR. Wang Y, Huang Y, Hobbs HH, Cohen JC. J Lipid Res., 2012 53:1932‐43. 13. Selective cannabinoid‐1 receptor blockade significantly benefits fatty acid and triglyceride metabolism in weight‐stable nonhuman primates. Vaidyanathan V, Bastarrachea RA, Higgins PB, Voruganti VS, Kamath S, DiPatrizio NV, Piomelli D, Comuzzie AG, Parks EJ. Amer J Physiol, 2012 [PMID: 22761159, PMIC 3468508], Endocrinology and Metabolism, 2012 303(5):E624‐34. 14. Use of emerging lipoprotein risk factors in assessment of cardiovascular risk. Grundy, S.M. JAMA, 2012 307:2540‐2542. 15. Fat distribution and insulin resistance in young adult non‐obese Asian Indian women. Szuszkiewicz‐Garcia, M., Li, R., Grundy, S.M., Abate, N., and Chandalia, M. Metab Syndr Relat Disord, 2012 [E pub ahead of print]. 16. Insulin activation of plasma non‐esterified fatty acid uptake in metabolic syndrome. Ramos‐Roman MA, Lapidot SA, Phair, Parks EJ. [PMC: 3417322]. Arteriosclerosis Thrombosis, & Vascular Biology, 2012 32:1799‐1808. 17. Deletion of GPIHBP1 causing severe chylomicronemia. Rios JJ, Shastry S, Jasso J, Hauser N, Garg A, Bensadoun A, Cohen JC, Hobbs HH. J Inherit Metab Dis., 2012 35:531‐40, PMID: 22008945. 18. Adiponectin as an independent predictor of the presence and degree of hepatic steatosis in the Dallas heart study. Turer, A.T., Browning, J.D., Ayers, C.R., Das, S.R., Khera, A, Vega, G.L., Grundy, S.M., and Scherer, P.E. J Clin Endo Metab, 2012 97:E982‐
E986. 19. The effect of angiotensin receptor blockade on insulin sensitivity and endothelial function in abdominally obese hypertensive patients with impaired fasting glucose. Perlstein, T.S., Henry, R.R., Mather, K.J., Rickels, M.R., Abate, N.I., Grundy, S.M., Mai, Y., Albu, J.B., Marks, J.B., Pool, J.L., Creager, M.A. Clin Sci (Lond), 2012 122:193‐202. [Epub ahead of print]. 20. Postprandial changes in plasma acylcarnitine concentrations as markers of fatty acid flux in overweight and obesity. Ramos‐Roman MA, Sweetman L, Valdez MJ, Parks EJ: [PMC3219812]. Metabolism, 2012 61(2):202‐212. 21. Pre‐diabetes, metabolic syndrome, and cardiovascular risk. Grundy, S.M. J Am Col Cardiol, 2012 59:635‐643. 22. Homozygosity mapping identifies a bile acid biosynthetic defect in an adult with cirrhosis of unknown etiology. Molho‐Pessach V, Rios JJ, Xing C, Setchell KD, Cohen JC, Hobbs HH. Hepatology, 2012 55:1139‐45. 23. Low levels of circulating troponin as an intermediate phenotype in the pathway to heart failure. de Lemos, J.A. and Grundy S.M. J Am Coll Cardiol, 2012 59:490‐492. 24. Getting the label in: Practical research strategies for tracing dietary fat. Lambert JE, Parks EJ: International J of Obesity, 2012 2:S43‐S50. 25. Enhanced fatty acid flux triggered by adiponectin over‐expression. Shetty S, Ramos‐Roman MA, Cho Y‐R, Brown J, Plutzky J, Muise ES, Horton JD, Scherer PE, Parks EJ. [PMIC 3249680]. Endocrinology, 2012 153(1):113‐122. 26. Genetic variant in PNPLA3 associated with nonalcoholic fatty liver disease in China. Li Y, Xing C, Cohen JC, Hobbs HH. Hepatology, 2012 55:327‐8. 27. Adipokines, body fatness, and insulin resistance among survivors of childhood leukemia. Tonorezos ES, Vega GL, Sklar CA, Chou JF, Moskowitz CS, Mo Q, Church TS, Ross R, Janiszewski PM, Oeffinger KC. Pediatr Blood Cancer, 2012 Jan 58(1):31‐6. doi: 10.1002/pbc.22964. Epub 2011 Jan 19. PubMed PMID: 21254377; PubMed Central PMCID: PMC3520427. 28. Postprandial metabolism of meal triglyceride in humans. Lambert JE, Parks EJ: [PMID: 22281699], Biochim Biophys Acta ‐ Molecular and Cell Biology of Lipids, 2012 1821(5):721‐726. 29. Cardiorespiratory fitness and metabolic risk. Grundy, S.M., Barlow, C.E., Farrell, S.W., Vega, G.L., and Haskell, W.L. Am J Cardiol, 2012. REVIEW ARTICLES/ EDITORIALS/ COMMITTEE REPORTS Lysophospholipid acyltransferases: 1‐acylglycerol‐3‐phosphate O‐acyltransferases (AGPATs) From discovery to disease. Agarwal AK. Current Opinion in Lipidology, 2012 23, 290‐302. BOOK CHAPTERS Lipodystrophy. Garg A. In Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K (eds). Fitzpatrick's Dermatology in General Medicine, 8th Edition, 2012 McGraw Hill, New York, NY, pp 755‐764, 2012