‫‪Drugs of Cardiovascular system‬‬
‫‪Section no : 3‬‬
‫‪Supervisor : DR. Mayada‬‬
‫‪Done by:‬‬
‫نور احمد صالح‬
‫اسماء احمد جبير‬
‫االء خليل اسعد‬
‫رنا توفيق ريان‬
‫اسيل هاشم أيوبي‬
‫‪0095008‬‬
‫‪0094955‬‬
‫‪0094957‬‬
‫‪0095973‬‬
‫‪0091324‬‬
ACE-Inhibitors : used in the management of Hypertension and CHF
Generic name
Trade name
Drug
Contraindications and Side effects
store/Producer
Captopril
Capoten
‫طنوس‬/
1. Hypersensitinity to any of these drugs or to
Bristol Myers
any component of the formulation.
2. Angioedema related to previous treatment
‫دار الدواء‬
Capocard
with an ACE inhibitor.
‫دار الدواء‬
Captopriland
Capocardplus
3.
Primary hyperaldosteronism.
hydrochlorothiazide
4. Pregnancy
Enalapril
Renitec
‫اداتكو‬/
MSD B. V
Enalapril with
hydrochlorothiazide
Vasopril
Lapril
Angiotec
Ace-press
Angiozide
Co-Renitec
‫الرام‬
‫الشرق االوسط‬
‫االردنية‬
‫االردنية السويدية‬
‫االردنية‬
‫اداتكو‬/
Siberian
‫محمد زريقات‬/
MSD B. V
Side effects:






Itching
Protein in the urine
Skin flushing
Increased heart rate (tachycardia)
Chest pain
Heart palpitations
Jamieson
Fosinopril
Imidapril
Lisinopril
Sinotic
Tanatril
Lisopril
‫المتحدة‬
‫الحكمة‬
‫الحياة‬
Linopril
‫الدولية‬
Angiotensin 2 : used in the management of Hypertension, CHF, selected case of diabetic neuropathy associated
with DM type 2
Generic name
Trade name
Drug
Contraindications and Side effects
store/Producer
Cadesartan
1. Hypersensitivity to any of these druge or any
Atacand
‫شاوي ورشيدات‬/
AstraZeneca
Candesartan and
hydrochlorothiazide
Eprosartan
Atacand plus
‫شاوي ورشيدات‬/
AstraZeneca
Blopress16 plus
Blo-press 8 plus
Teveten
‫العربية‬
‫العربية‬
‫خريم‬/
Solvay
pharmaceutical
Eprosartan and
hydrochlorothiazide
Teveten plus
Irbesartan
Aprovel
‫خريم‬/
Solvay
pharmaceutical
‫االلفة‬/
Sanofi-Aventis
Losartan
Valsartan
Azarten
Arbiten
‫الحياة‬
‫االردنية السويدية‬
Anti ischematicagents , used in the management of Angina.
component of the formulation.
2. Hypersensitivity to all other A-II receptor
antagonists.
3. Pregnancy
Side effects:
 unexplained skin rash
 Itching
 Difficulty in breathing or swallowing
 Dizziness, light-headedness.
Generic name
Trade name
Trimetazidine
Vastarel
Drug
store/Producer
‫مستودع االدوية االردني‬
Contraindications and Side effects
Side effects:
Gastrointestinal disturbances, vomiting, nausea.
Anti arrhythmic : used in the management of Tachyarrhythmia and VF
Generic name
Trade name
Lidocaine
LidocaineHCl
Amiodorone
Cordarone
Drug
store/Producer
‫العربية‬
‫االلفة‬/
Sanofi-Aventis
Contraindications and Side effects
1. Hypersensitivity to these drugs or any
component of the formulation.
2. In sever degree of Heart Block
Side effects of amiodarone:

Deposits on the cornea of the eyes

Sensitizes the skin to sunlight

Thyroid disorders, both hypothyroidism (low
thyroid) and hyperthyroidism (high thyroid.).

liver toxicity
Anti hemorrhagic : used in the management of capillary hemorrhage including Hemorrhoids.
Generic name
Trade name
Etamsylate
Dicynone
Drug
store/Producer
‫مستودع االدوية العربي‬/
Lidocaine
Proctolar
‫المركز العربي‬/
OM pharma
Contraindications and Side effects
----------------------------------------------------------------
Arab Center for
pharmaceuticals &
Chemicals
Proctoheal
Protoglyvenol
‫دار الدواء‬
‫النابلسي‬/
Novartis
Consumer health
Herbal remedy
Neohealar
‫العربية‬
Anti thrombotic and platelet aggregation inhibitor agents : used to prevent thrombotic attacks in susceptible
patients including DVT, Pulmonary embolism,
Generic name
Trade name
Drug
Contraindications and Side effects
store/Producer
Tinzaparin
‫ شركة العرب للصناعات‬1. Hypersensitivity any of these agents.
Innohep
‫الطبية والغذائية‬/
2. History of heparin or dalteparin- induced
LEO Phar.
thrombocytopenia
Products
Dalteparin
Fragmin
prefilled syringe
‫الخوري‬/
Pharmacia
Side effects:
Clopidogrel
hydrogen sulphate
Clovex
Plavix
‫االردنية السويدية‬
‫االلفة‬/
Sanofi-Aventis
Platil
Dipyramidole
Antiplate
Acetylsalisyclic acid
Aspirin
‫الدولية‬
‫الشركة العربية‬
‫للصناعات الدوائية‬
‫والزراعية‬
‫الخوري‬/






Unusual headaches, dizziness, or
weakness, which may be signs of bleeding
in the brain
Unusual bruising (bruises that develop
without known cause or grow in size)
Blood in the urine and the stool.
Bleeding gums
Bleeding from cuts that takes a long time to
stop
Coughing up blood.
Bayer Health care
Salisal
‫المتحدة‬
Anti varicose agents : used in the management of Varicose veins and Hematoma
Generic name
Trade name
Drug
Contraindications and Side effects
store/Producer
Heparin
Lioton
‫الشرق‬/
Side effects:
A.Menarini
International
Heparin and
allantoin
Contractubexgel
Heparinoid
Lasonil
‫جرش‬/



Merz
pharmaceuticals
Mild pain
Redness
Mild itching of the feet and bluish-colored
skin.
‫الخوري‬/
Bayer Health care
Hirudoid
‫الكرمل‬/
Sankyo-Pharma
B-blockers : used in the management of Hypertension , Angina, HF and cardiac arrhythmia
Generic name
Trade name
Drug
Contraindications and Side effects
store/Producer
Nebivolol HCL
Nebilet
‫الشرق‬/
1. Hypersensitivity to any of these drugs
A.Menarini
2. Undercompensated heart failure
International
3. Pregnancy and lactation.
Atenolol
‫الحكمة‬
Hypoten
4. Non-selective blocker( Propranolol) is not
‫الرام‬
Loten
used with asthmatic patients or in case of
Tenormin
‫الشاوي ورشيدات‬/
COPD.
AstraZeneca
Atelol
Bisoprolol
Cardiosafe
B-cor
Bisoprol
Con-Cor
‫العربية‬
‫االردنية‬
‫االردنية السويدية‬
‫المتحدة‬
‫النابلسي‬/
Merck
Carvidilol
Cardilol
Dilatrend
‫الحكمة‬
‫شاوي ورشيدات‬/
Roche
Metoprolol
Betalock
‫شاوي ورشيدات‬/
Propranolol
Inderal
‫شاوي ورشيدات‬/
AstraZeneca
Side effects:






Dizziness, lightheadedness, or fainting
spells
Cold, tingling, or numbness in the hands or
feet
Worsening of asthma
Worsening of heart failure
Confusion
An irregular heartbeat (arrhythmia)
AstraZeneca
Indicardin
Atensin
‫العربية‬
‫الهالل‬/
Medochemie
CCB : used in the management of hypertension and Angina ( reversible vasospasm )
Generic name
Trade name
Drug
Contraindications and Side effects
store/Producer
Amlodipine
‫الحكمة‬
Vascor
Amlodar
Hypodipine
Norvasc
‫دار الدواء‬
‫الشرق االوسط‬
‫الصباغ‬/
Hypersensitivity to any of these agents.
Pfizer
Lowvasc
Diltiazem
Bi-tildiem
‫المتطورة‬
‫االلفة‬/
Sanofi-Aventis
Monotildiem
‫االلفة‬/
Sanofi-Aventis
Dilzem
‫الدوجاني‬/
Pfizer
Felodipine
Corzem
Plendil
Nefidipine
Adalat
‫المتحدة‬
‫شاوي ورشيدات‬/
AstraZeneca
‫الخوري‬/
Bayer Health care
Verapamil
Isoptin
‫السختيان‬/
Abbott
Diuretics : relive Edema and used in combination with other drugs in the management of Hypertension.
Generic name
Trade name
Drug
Contraindications and Side effects
store/Producer
Furosemide
Lasix
‫االلفة‬/
1. Hypersensitivity to any of these agents.
Sanofi-Aventis
2. In sever electrolyte depletion until the case
‫العربية‬
Diusemide
is corrected.
‫دار الدواء‬
Amiloride and
Amuretic
hydrochlorothiazide Uniretic
‫المتحدة‬
Side effects:
Spironolactone
Aldactone
‫الصباغ‬/
 Headache and dizziness
Pfizer
Spironolactone and
hydrochlorothizide
Hydrochlorothiazide
Chlortadilone and
atenolol
Norcatone
Aldactide
‫االردنية‬
‫الصباغ‬/
Pharmacia
Monozide
Modrex
Hyporetic
Tenoretic
‫االردنية‬
‫المتحدة‬
‫الحكمة‬
‫شاوي ورشيدات‬/
AstraZeneca



Increased blood sugar (hyperglycemia).
Low blood pressure
Some agents results in sensitization of skin.
Vaso-protective and capillary stabilizing agent : used in the management of hemorrhoids.
Generic name
Trade name
Drug
Contraindications and Side effects
store/Producer
Diosmin and
Diovenor
‫الجودة‬/
flavonoid expressed
Innotech
---------------------------------------------------------------in hesperidin
‫مستودع االدوية‬
Daflon
‫االردني‬/
Les Laboratories
Servier
Rutoside
Venoruton
‫النابلسي‬/
Novartis
Consumer Health
Vasodilators : used in the management of Angina and vascular occlusive disorders.
Generic name
Trade name
Drug
Contraindications and Side effects
store/Producer
Naftidrofuryl
Praxilene
‫النابلسي‬/
1. Hypersensitivity to any of these agents.
Merck
2. Avoid the concurrent use of
Pentoxifyllin
‫الدولية‬
Pentyllin
isosorbidedinitrate with sildenafil.
‫طنوس‬/
Isosorbidedinitrate Isoket
Schwarz
Side effects of isosorbidedinitrate:
 Dizziness
 Flushing of the face and neck
 Headache
 Nausea and vomiting.
 severe allergic reactions
Lipid modifying agents : used in the management of Dyslipidemia
Generic name
Trade name
Drug
Contraindications and Side effects
store/Producer
Fibrates
1. Hypersensitivity to any of these agents.
2. Breast feeding and pregnancy.
Gemfibrozil
Lopid
‫الدوجاني‬/
Pfizer
Low lip
HMG-CoA inhibitors
Atorvastatin
Zocor
‫المتحدة‬
‫اداتكو‬/
MSD B. V
Atorvast
Vastor
Lipodar
Lipitor
‫االردنية السويدية‬
‫الحكمة‬
‫دار الدواء‬
‫الدوجاني‬/
Caduet
‫الصباغ‬/
Aditor
Tulip
‫المتطورةللصناعةالدوائية‬
‫النابلسي‬/
Pfizer
Pfizer
Sandoz GmbH
Rosuvastatin
Crestor
Simvastatin
Simvatin
Lipomid
Sivacor
Simver
‫الشاوي ورشيدات‬/
AstraZeneca
Anti hypertensive agents
Generic name
Trade name
Methyldopa
Moxonidine
Dopanore
Physioten
‫الدولية‬
‫الشرق االوسط‬
‫المتطورة‬
‫نهر االردن‬
Drug
store/Producer
‫االردنية‬
‫خريم‬/
Solvay
pharmaceutical.
Alpha-blocker
Doxazosin
Alpha press
‫الشرق االوسط‬
Contraindications and Side effects
Hypersensitivity to any of these agents.
Side effects of Methyl dopa:







Dizziness
Drowsiness
Dry mouth
Headache
Severe allergic reactions
Weight gain
Yellowing of the skin or eyes
Cardiac stimulants and cardiac glycosides : used in the management of CHF
Generic name
Trade name
Drug
Contraindications and Side effects
store/Producer
Digoxin
Lanoxin
‫سليمان طنوس‬/
1. Hypersensitivity to any of these agents.
GlaxoSmithKline
2. Avoid using digoxin in case of history of
Cardiac stimulants
toxicity.
Dopamine
Dopamine HCl
‫المنى – الهالل‬/
DEMO S.A
Milrinone
Primalon
‫الحكمة‬
Side effects of Digoxin:
Elevations of Digoxin levels can also be
associated with visual hallucinations, blurred
vision, and nausea.