• Choice of GCC:

• Biologic half-life = Time to leave body tissues• More representative than plasma half-life for GCC

• Avoid GCC with high mineralocorticoid (fluid retention) potency

• Administration

Multiple routes: Oral, parenteral, topical, inhalational, etc.

Admin in the morning (before 9AM) = Optimal

• Dosage Guidelines

Individualised via trial & error

High-dose prolonged therapy only if 1) Life-threatening or 2) Potential for permanent disability

• Alternate-day therapy = Intermediate-acting GCC every other day

Advantages: ↓ Adrenal Suppression + Growth delay & Overall toxicity

Drawback: Symptoms flare-up on the non-dosing day

Spell: 5. endocrine pathopharmacology