Dieusel Paul-
What is the role of inflammation in the immune system?
the immune system's response to harmful stimuli, such as pathogens, damaged cells, toxic compounds, or irradiation. Recruits WBCs to infection.
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what is TLR4 in immunology?
intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system.
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TLR4 recognizes bacterial LPS with these two proteins?
MD2 and CD14
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TLR4 mediated signaling step 1: LPS and LBP
Lipopolysaccharide (LPS)-binding protein (LBP) binds LPS to cell surface receptors (TLR4), thereby initiating an innate host response.
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TLR4 mediated signaling step 2: myD88
provides instructions for making a protein involved in signaling within immune cells.
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TLR4 mediated signaling step 3: IKK
IKK triggers IKB
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TLR4 mediated signaling step 4: IκB kinase
The IkBs bind to NF-kB IκBα is an unstable protein whose rapid degradation is slowed upon binding to NF-κB.
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TLR4 mediated signaling step 5: in the nucleus
NfkB goes through transcription and inflammatory cytokine produced
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TLR4 mediated signaling step 6: cytokines
- leave the cytoplasm
- recruit WBC's
- site of infection traced by PMN
- leads to bacteria. phagocytize.
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what is NfkB's role in the in innate immune response?
NF-κB plays a critical role in regulating the survival, activation and differentiation of innate immune cells and inflammatory T cells
