tetracycline, doxycycline, minocycline
What are first generation tetracyclines?
Tigecycline, Omadacycline, Eravacycline, Sarecycline
What are our second generation tetracyclines?
doxycycline, minocycline, omadacycline, tetracycline,
Which Tetracyclines can be taken orally & IV?
tigecycline, eravacycline
Which Tetracyclines can IV only?
Sarecycline
Which Tetracycline can only be taken orally?
d
Which tetracycline causes CNS SE's like vertigo & ataxia?
a) tigecycline
b) Omadacycline
c) Doxycycline
d) Minocycline
d
Which tetracycline decreases the efficacy of oral contraceptives?
a) doxycycline
b) tetracycline
c) minocycline
d) demecyclocline
chlamydia, genital tract infections, vibrio cholera, CA-MRSA, lyme disease, trench fever
Doxycycline is a 1st line treatment for what ?
doxycycline + AG; aids patients
How do we treat Trench fever? Who is it a first line treatment for?
complicated: skin infection, intra-abdominal infection
Tigecycline tx?
c
Which tetracycline has a black box warning for increased risk of death?
a) omadacycline
b) seracycline
c) tigecycline
d) minocycline
CABP, acute bacterial skin infection
Omadacycline tx?
tc efflux in gm +; ribosome protection
What specific resistance mechanism does Omadacycline possess?
a
Which tetracycline has a fluorine in it?
a) eravacycline
b) tetracycline
c) minocycline
d) demecyclocline
tc efflux in gm+ & gm-; ribosome protection
What specific resistance mechanism does Eravacycline possess?
eravacycline
Which tetracycline failed clinical trials in patients for complicated UTI?
sarecycline
Which tetracycline has an unknown MOA?
complicated intra-abdominal infections
Eravacycline tx?
moderate-severe acne vulgaris
Sarecycline tx?
less active; less damage to GI flora
What are pros & cons associated with Sarecycline?
a
Which tetracycline has a glycylamido group?
a) tigecycline
b) Omadacycline
c) Doxycycline
d) eravacycline
b,d
Which tetracycline has a trimethylamino group?
a) tigecycline
b) Omadacycline
c) Doxycycline
d) eravacycline
tigecycline, minocycline, doxycycline
Which Tetracyclines are semi-synthetic?