2023-04-15T05:14:15+03:00[Europe/Moscow] en true <p>methenamine, nitrofurantoin, sulfasalazine</p>, <p>inhibits tetrahydrofolate synthesis by inhibiting dihydropteroate synthase; acts as PABA analogue </p>, <p>inhibits dihydrofolate reductase; needed to synthesize tetrahydrofolate</p>, <p>strep, pneumococcal, mssa</p>, <p>uti, pneumocystis pneumonia, sinusitis, otitis media</p>, <p>steven johnson's syndrome, crystalluria </p>, <p>Pseudomonas</p>, <p>anaerobes</p>, <p>rickettsia </p>, <p>e.coli, shiegella, chlamydia, h.flu</p>, <p>toxoplasma, pneumocystis </p>, <p>prodrug that generates superoxide anion that destroys DNA and proteins; cidal</p>, <p>N&amp;V, disulfiram-like activity, furry tongue</p>, <p>1st line: anaerobic infections, c.diff, PMC</p>, <p>coumarin anticoagulants, increased lithium levels, avoid alcohol</p>, <p>bacterial vaginosis </p>, <p>no disulfiram reaction</p> flashcards
Sulfonamides and other UTI agents (General)

Sulfonamides and other UTI agents (General)

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  • methenamine, nitrofurantoin, sulfasalazine

    Which drugs are Prodrugs? (3)

  • inhibits tetrahydrofolate synthesis by inhibiting dihydropteroate synthase; acts as PABA analogue

    What is the MOA for Sulfonamides?

  • inhibits dihydrofolate reductase; needed to synthesize tetrahydrofolate

    What is the MOA for Trimethoprim?

  • strep, pneumococcal, mssa

    What Gm (+) bacteria are Sulfa drugs active against?

  • uti, pneumocystis pneumonia, sinusitis, otitis media

    What conditions do we use Sulfa drugs to treat?

  • steven johnson's syndrome, crystalluria

    What general SE's do we see with Sulfa drugs?

  • Pseudomonas

    Which Gm (-) are these NOT active against?

  • anaerobes

    Which group of bacteria are these NOT active against?

  • rickettsia

    Sulfa drugs can stimulate the growth of

  • e.coli, shiegella, chlamydia, h.flu

    What Gm (-) species are these active against?

  • toxoplasma, pneumocystis

    Patients with aids are susceptible to ______ & _______. Using Sulfa drugs are helpful with infections caused by these organisms.

  • prodrug that generates superoxide anion that destroys DNA and proteins; cidal

    Metronidazole MOA?

  • N&V, disulfiram-like activity, furry tongue

    What are SE's associated with Metronidazole?

  • 1st line: anaerobic infections, c.diff, PMC

    Metronidazole Tx?

  • coumarin anticoagulants, increased lithium levels, avoid alcohol

    CI's associated with Metronidazole?

  • bacterial vaginosis

    Secnidaozle Tx?

  • no disulfiram reaction

    How is Secnidazole different from Metronidazole?