RNA-Seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), uses next-generation sequencing (NGS) to reveal the presence and quantity of RNA in a biological sample at a given moment in time.
The hammerhead ribozyme is a RNA molecule motif that catalyzes reversible cleavage and joining reactions at a specific site within an RNA molecule.
EteRNA is a browser-based "game with a purpose", developed by scientists at Carnegie Mellon University and Stanford University, that engages users to solve puzzles related to the folding of RNA molecules.
RNA polymerase (RNAP or RNApol) (Ribonucleic acid), also known as DNA-dependent RNA polymerase, is an enzyme that produces primary transcript RNA.
A transfer RNA (abbreviated tRNA and formerly referred to as sRNA, for soluble RNA) is an adaptor molecule composed of RNA, typically 76 to 90 nucleotides in length, that serves as the physical link between the mRNA and the amino acid sequence of proteins.
RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression, typically by causing the destruction of specific mRNA molecules.
Small interfering RNA
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA molecules, 20-25 base pairs in length.
Five prime untranslated region
The 5' untranslated region (5′ UTR) (also known as a Leader Sequence or Leader RNA) is the region of an mRNA that is directly upstream from the initiation codon.
Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.
A microRNA (abbreviated miRNA) is a small non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression.
RNase III is a type of ribonuclease that specifically binds to and cleaves double-stranded RNA (dsRNA).
A non-coding RNA (ncRNA) is an RNA molecule that is not translated into a protein.
History of RNA biology
Numerous key discoveries in biology have emerged from studies of RNA (ribonucleic acid), including seminal work in the fields of biochemistry, genetics, microbiology, molecular biology, molecular evolution and structural biology.
Polymorphism in microRNA Target Site (PolymiRTS) is a database of naturally occurring DNA variations in putative microRNA target sites.
RNA Biology is a peer-reviewed scientific journal in the field of ribonucleic acid (RNA) research.
In bioinformatics, lncRNAdb is a biological database of Long non-coding RNAs The database focusses on those RNAs which have been experimentally characterised with a biological function.
Rfam is a database containing information about non-coding RNA (ncRNA) families and other structured RNA elements.
Atlas of UTR Regulatory Activity
It includes basic annotation, phylogenetic conservation, binding sites for RNA-binding proteins and miRNA, cis-elements, RNA methylation and editing data, and more, for human and mouse.
Signal recognition particle RNA
The signal recognition particle RNA, also known as 7SL, 6S, ffs, or 4.
snRNPs (pronounced "snurps"), or small nuclear ribonucleo proteins, are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs.
Nucleic acid analogue
Nucleic acid analogues are compounds which are analogous (structurally similar) to naturally occurring RNA and DNA, used in medicine and in molecular biology research.
RNA-dependent RNA polymerase
RNA-dependent RNA polymerase (RdRP), (RDR), or RNA replicase, is an enzyme that catalyzes the replication of RNA from an RNA template.
Post-transcriptional regulation is the control of gene expression at the RNA level, therefore between the transcription and the translation of the gene.