Radiopharmaceuticals

-an unstable isotope which undergoes radioactive transformation

-in the transformation emits energy in the form of radiation

- a radionuclide combined with a chemical molecule to confer localized effects

90% of radiopharmaceuticals are used for therapeutics. T/F?

Which is the fundamental unit of radioactivity?

a) Curie (Ci)

b) Rad

c) Becquerel (Bq)

d) Gray (Gy)

Which is the international unit of disintegration per second?

a) Curie (Ci)

b) Rad

c) Becquerel (Bq)

d) Gray (Gy)

Which is the amount of radiation absorbed by body tissue?

a) Curie (Ci)

b) Rad

c) Becquerel (Bq)

d) Gray (Gy)

Which is the international unit for absorbed dose?

a) Curie (Ci)

b) Rad

c) Becquerel (Bq)

d) Gray (Gy)

-fission/neutron bombardment

-consists of high and low flux neutron beams

-electromagnetic field to propel charged particles in a vacuum at high speeds and energies

•Charged particles such as protons, deuterons, ⍶ particles, ³He particles, are accelerated in circular path under vacuum by an electromagnetic field and bombard non-radioactive materials to create radioisotopes

-is an imaging test that can reveal the metabolic or biochemical function of tissues and organs.  Primarily for cardiac, cancer, neurological scans

What is the purpose of Clyclotrons?

Which particle has the largest mass; is composed of 2 protons & 2 neutrons?

a) alpha particle

b) beta particle

c) gamma photon

d) auger-electron

Which particle ONLY has a positive charge

a) alpha particle

b) beta particle

c) gamma photon

d) auger-electron

Which particle can be either positive or negative?

a) alpha particle

b) beta particle

c) gamma photon

d) auger-electron

Which particles are primarily used for therapeutics?

a) alpha particle

b) beta particle

c) gamma photon

d) auger-electron

Which particle is the most widely used in nuclear medicine, primarily for diagnostics & imaging?

a) alpha particle

b) beta particle

c) gamma photon

d) auger-electron

Which particle relies on a large number of low-energy of electrons for its effect?

a) alpha particle

b) beta particle

c) gamma photon

d) auger-electron

Which particle possess no ionizing ability to other atoms?

a) alpha particle

b) beta particle

c) gamma photon

d) auger-electron

-most commonly used medical radioisotope

- widely used for diagnostic tissue imaging

-can be used therapeutically and diagnostically

•the period of time to reduce the radioactivity level of an internal organ or of the whole body to half its original value due to both elimination and decay, T_eff

-conjugation to an antibody via a compound (linker) that can chelate the isotope

-polymer matrix that contains radionuclide that forms a gel when deposited into tissue

-places radioactive sources directly into tumor tissues.

-inserted into arteries through a catheter into tumor tissue.

Which carrier type has improved localized distribution of radiation dose?

a) radioconjugate

b) radiogel

c) seed implant

d) beads

Which carrier type is a form of precision nuclear medicine unique for a particular type of tumor?

a) radioconjugate

b) radiogel

c) seed implant

d) beads