2023-10-27T01:59:34+03:00[Europe/Moscow] en true <p>12&gt; mg/dL</p>, <p>kidney stones, bone pain, pancreatitis, constipation, polyuria, depressed/confused</p>, <p>lithium, thiazides</p>, <p>hyperparathyroidism </p>, <p>positive allosteric modulators of CaSR on PTH gland; provide feedback to PT gland that calcium levels are appropriate and PTH secretion can slow </p>, <p>cinacalcet, etecalcetide </p>, <p>activate VDR to reduce PTH synthesis and promote calcium absorption/homeostasis </p>, <p>calcifediol, paricalcitol, doxercalciferol </p>, <p>c</p>, <p>recombinant analog of human calcitonin; counters PTH; increases osteoblast deposition of calcium </p>, <p>correct dehydration, identify underlying disorders, reduce calcium absorption in GI, increase renal excretion of calcium, promote bone deposition, inhibit bone resorption </p>, <p>b</p>, <p>c</p>, <p>c</p>, <p>a,d</p>, <p>osteonecrosis of jaw, atypical femoral fracture, injection site reactoins</p>, <p>d</p>, <p>inhibits farnesyl pyrophosphate; this reduces osteoclasts ability to bind to bone; also increases apoptosis</p>, <p>bind to RANK-L receptor and reduce osteoclast maturation; decreasing the function/survival of osteoclasts </p>, <p>-nate suffix</p>, <p>d</p>, <p>Pamidronate, Alendronate, Zoledronate</p> flashcards
Pharmacology of Hypercalcemia

Pharmacology of Hypercalcemia

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  • 12> mg/dL

    Hypercalcemia is defined as

  • kidney stones, bone pain, pancreatitis, constipation, polyuria, depressed/confused

    Symptoms of Hypercalcemia? (6)

  • lithium, thiazides

    Which medications can cause hypercalcemia? (2)

  • hyperparathyroidism

    What is the most common cause of hypercalcemia?

  • positive allosteric modulators of CaSR on PTH gland; provide feedback to PT gland that calcium levels are appropriate and PTH secretion can slow

    Calcimimetics MOA?

  • cinacalcet, etecalcetide

    What are the calcimimetics? (2)

  • activate VDR to reduce PTH synthesis and promote calcium absorption/homeostasis

    Vitamin D analogs MOA?

  • calcifediol, paricalcitol, doxercalciferol

    What are the Vitamin D analogs? (3)

  • c

    Which requires bioactivation in the liver?

    a) calcimimetics

    b) Paricalcitol

    c) Doxercalciferol

    d) calcitonin

  • recombinant analog of human calcitonin; counters PTH; increases osteoblast deposition of calcium

    Calcitonin MOA?

  • correct dehydration, identify underlying disorders, reduce calcium absorption in GI, increase renal excretion of calcium, promote bone deposition, inhibit bone resorption

    What are the strategies for treating Hypercalcemia? (6)

  • b

    Which are used to reduce calcium absorption in the GI?

    a) Denosumab

    b) prednisone

    c) calcitonin

    d) -Nates

  • c

    Which is used to increase renal excretion of calcium?

    a) Denosumab

    b) prednisone

    c) calcitonin

    d) -Nates

  • c

    Which is used to promote bone deposition?

    a) Denosumab

    b) prednisone

    c) calcitonin

    d) -Nates

  • a,d

    Which is used to inhibit bone resorption?

    a) Denosumab

    b) prednisone

    c) calcitonin

    d) -Nates

  • osteonecrosis of jaw, atypical femoral fracture, injection site reactoins

    What are AE's of Denosumab & Bisphosphonates? (3)

  • d

    Which have a half-life of over 100 hours?

    a) Denosumab

    b) prednisone

    c) calcitonin

    d) -Nates

  • inhibits farnesyl pyrophosphate; this reduces osteoclasts ability to bind to bone; also increases apoptosis

    Bisphosphonates MOA?

  • bind to RANK-L receptor and reduce osteoclast maturation; decreasing the function/survival of osteoclasts

    Denosumab MOA?

  • -nate suffix

    What are the bisphosphonates?

  • d

    Which is contraindicated in esophageal abnormalities?

    a) Denosumab

    b) prednisone

    c) calcitonin

    d) -Nates

  • Pamidronate, Alendronate, Zoledronate

    Rank these in terms of potency. (least to most)

    Zoledronate, Pamidronate, Alendronate