Hosam Mohamed-
amiodarone, dronedarone, sotalol, dofetilide, ibutilide
What are our K+ channel blockers? (5)
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block potassium, sodium, and calcium channels; also blocks B-adrenoreceptors
MOA of Amiodarone & Dronedarone?
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delay formation of action potential; increase ERP
Blocking sodium = (2)
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slow repolarization; longer phase 3; increase ERP
Blocking potassium =(3)
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decreases automaticity
Blocking B-adrenoreceptors =
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CYP2C9; CYP2D6
Which enzymes does Amiodarone inhibit?
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a
Which can cause pulmonary fibrosis?
a) amiodarone
b) dronedarone
c) sotalol
d) dofetilide
e) ibutilide
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a
Which can interfere with thyroid function?
a) amiodarone
b) dronedarone
c) sotalol
d) dofetilide
e) ibutilide
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a
Which can cause blue-gray skin?
a) amiodarone
b) dronedarone
c) sotalol
d) dofetilide
e) ibutilide
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a
Which one contains an Iodine?
a) amiodarone
b) dronedarone
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b
Which is the least lipophilic?
a) amiodarone
b) dronedarone
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a
Which has a longer half-life?
a) amiodarone
b) dronedarone
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b
Which is more prone to cause liver injury?
a) amiodarone
b) dronedarone
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b
Which has a Boxed Warning against its use in Acute Heart Failure (AHF)?
a) amiodarone
b) dronedarone
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b
Which is less efficacious?
a) amiodarone
b) dronedarone
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a
Which is more toxic?
a) amiodarone
b) dronedarone
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c
Which is a racemic mixture?
a) amiodarone
b) dronedarone
c) sotalol
d) dofetilide
e) ibutilide
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c
Which can cause DOSE-dependent QTc prolongation/TDP?
a) amiodarone
b) dronedarone
c) sotalol
d) dofetilide
e) ibutilide
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d,e
Which block rectifier K+ channels?
a) amiodarone
b) dronedarone
c) sotalol
d) dofetilide
e) ibutilide
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a
Which isomer promotes more beta blocking action
a) L-Sotalol
b) Sotalol
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b
Which promotes slow inward flow of Na+ causing AP prolongation?
a) Doefetilide
b) Ibutilide
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increasing duration of phase 3 & duration of ERP
What is the clinical application of K+ channel blockers?
