Hosam Mohamed-
b,d
Which agents act on the S phase?
a) Vinca alkaloids
b) Antimetabolites
c) Taxanes
d) Topoisomerase inhibitors
-
a,c
Which agents act on the M phase?
a) Vinca alkaloids
b) Antimetabolites
c) Taxanes
d) Topoisomerase inhibitors
-
alkylating agents, platinum analogs
What are the Cell Cycle-Nonspecific agents? (2)
-
covalently bind to nucleophilic sites on DNA to form intrastrand/interstrand cross-links, causing DNA damage and cell death
Platinum Agents MOA?
-
cisplatin, carboplatin
What are the Platinum agents? (2)
-
myelosuppression, nephrotoxicity, N/V, ototoxicity, peripheral neuropathy
What are the DLT associated with Platinum Agents? (5)
-
a
Which has more nephro/GI toxicity?
a) Cisplatin
b) Carboplatin
-
b
Which has more myelosuppression?
a) Cisplatin
b) Carboplatin
-
a
Which is a Folic Acid Analog?
a) Pemetrexed
b) Gemcitabine
-
b
Which is a Deoxycytidine Analog?
a) Pemetrexed
b) Gemcitabine
-
Pemetrexed, gemcitabine
What are the antimetabolites? (2)
-
a
Which causes Hand-Foot Syndrome?
a) Pemetrexed
b) Gemcitabine
-
inhibits: thymidylate synthase & dihydrofolate reductase; inhibits DNA/RNA synthesis
Pemetrexed MOA?
-
polyglutamation; causes drug to remain in cancer cells and maintain inhibition of the purine pathway
What is critical for Pemetrexed's therapeutic activity?
What does this cause?
-
b
Which is a prodrug?
a) Pemetrexed
b) Gemcitabine
-
triphosphate
Gemcitabine's active metabolite is a _________ form.
-
inhibits ribonucleotide reductase-decreases DNA synthesis; directly incorporates into DNA-strand termination; inhibits DNA polymerase- blocks repair
Gemcitabine MOA? (3)
-
a
Albumin-bound form used in patients with hypersensitivity.
a) Abraxane
b) Paclitaxel
c) Docetaxel
-
c
Which has the most neutropenia?
a) Abraxane
b) Paclitaxel
c) Docetaxel
-
c
Which is a semisynthetic derivative?
a) Abraxane
b) Paclitaxel
c) Docetaxel
-
prevent microtubule depolymerization; causing M-phase arrest and apoptosis
Taxanes MOA?
-
abraxane, paclitaxel, docetaxel
What are the Taxanes? (3)
-
Vinorelbine
is a potent vesicant
-
vesicant
- a chemical compound that causes severe skin, eye and mucosal pain and irritation.
-
inhibits microtubule formation; causes M-phase arrest and apoptosis
Vinorelbine MOA?
-
c
Which is a prodrug?
a) Topotecan
b) Etoposide
c) Irinotecan
-
c
Which has BBW for diarrhea?
a) Topotecan
b) Etoposide
c) Irinotecan
-
Tecans; Etoposide
The ________ inhibits topoisomerase I, while _________ inhibits
topoisomerase II.
-
b
Which is available orally & IV?
a) Topotecan
b) Etoposide
c) Irinotecan
-
topoisomerase I
- repairs single strand cuts
-
topoisomerase II
-repairs double-stranded cuts
-
nucleic acid analog; folate antagonist
Gemcitabine is a _______ while Pemetrexed is a _________.
