Hosam Mohamed-
omalizumab
What is our anti-IgE mAb?
-
f; can also reduce late phase by preventing IgE binding to other cells
Omalizumab can only inhibit early phase response. T/F?
-
IL-5
- the major cytokine involved in growth, differentiation, and activation of eosinophils
-
a,c
Which are anti-IL-5s?
a) Mepolizumab
b) Benralizumab
c) Reslizumab
-
b
Which is an Anti-IL-5 receptor blocker?
a) Mepolizumab
b) Benralizumab
c) Reslizumab
-
IL4; IL-13
_______ and ______ are key cytokines that promote IgE synthesis and
inflammatory cell recruitment
-
blocks the IL-4Ra common subunit; blocks signaling of IL-4 & IL-13
Dupilumab MOA?
-
tezepelumab
What is our anti-TSLP mAb?
-
d
Which is involved in the early asthmatic response?
a) IL-5
b) IL-4
c) IL-13
d) IgE
-
mast cells; smooth muscle contraction
Once produced, IgE binds to _______ in the airway mucosa; this eventually
leads to ___________.
-
a
Which is involved in growth, differentiation, and activation of eosinophils?
a) IL-5
b) IL-4
c) IL-13
d) IgE
-
IL-5 secreting T2 lymphocytes
What is the cause of eosinophilic asthma?
-
b,c
Which promote IgE synthesis & inflammatory cell recruitment?
a) IL-5
b) IL-4
c) IL-13
d) IgE
-
e
Which is derived from epithelial cells and heavily involved in the pathogenesis of asthma?
a) IL-5
b) IL-4
c) IL-13
d) IgE
e) TSLP
