2023-04-25T00:44:30+03:00[Europe/Moscow] en true <p>primary packaging </p>, <p>secondary packaging </p>, <p>container closure</p>, <p>market package</p>, <p>glass containers</p>, <p>a</p>, <p>b</p>, <p>c</p>, <p>a,b</p>, <p>thermoplastics</p>, <p>thermosets </p>, <p>permeation </p>, <p>leaching </p>, <p>sorption</p>, <p>chemical reactivity</p>, <p>modification</p>, <p>a</p>, <p>b</p>, <p>c</p>, <p>closure</p>, <p>closure liners</p>, <p>metal tube</p>, <p>plastic tube </p>, <p>laminated </p>, <p>functional packaging </p>, <p>overt tamper</p>, <p>a</p>, <p>a</p>, <p>c</p>, <p>d</p>, <p>a</p>, <p>b</p>, <p>a</p>, <p>c</p>, <p>d</p> flashcards
Packaging

Packaging

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  • primary packaging

    - a packaging component that is or may be direct contact with the dosage form.

  • secondary packaging

    -a packaging component that is not and will not be in direct contact with the dosage form

  • container closure

    - the sum of packaging components that contain & protect the dosage form; can include primary & secondary packaging.

  • market package

    -container closure system and labeling

    - associated components like: dosing cups, droppers, spoons

  • glass containers

    - is the traditional gold standard for pharmaceutical packaging.

  • a

    Which type of glass is the highest quality and used for the MOST demanding applications?

    a) Type I: Borosilicate

    b) Type II: Treated Soda-Lime

    c) Type III: Regular Soda-Lime

  • b

    Which type of glass is suitable for most acidic and neutral aqueous products?

    a) Type I: Borosilicate

    b) Type II: Treated Soda-Lime

    c) Type III: Regular Soda-Lime

  • c

    Which type of glass is NOT used for parenteral products?

    a) Type I: Borosilicate

    b) Type II: Treated Soda-Lime

    c) Type III: Regular Soda-Lime

  • a,b

    Glass used for pharmaceutical containers is which type(s)?

    a) Type I: Borosilicate

    b) Type II: Treated Soda-Lime

    c) Type III: Regular Soda-Lime

  • thermoplastics

    -high molecular weight; amorphpous polymers with weak intermolecular bonds

  • thermosets

    -polymers that cross-link and form irreversible bonds between polymer chains

    -excellent chemical resistance & mechanical properties

  • permeation

    -transmission of gasses, vapors, or liquids through plastic packaging; materials have an adverse effect on the drug

    -oxidation, hydrolysis

  • leaching

    -constituent from plastic container leaches into drug product causing toxic effect or catalyzes a reaction

  • sorption

    -removal of constituents from the drug product by the package material; losses can affect efficacy and cause the loss of preservatives

  • chemical reactivity

    -when ingredients in the drug product and the plastic formulation interact with one another

  • modification

    -physical and/or chemical alteration of the packaging material by the drug product

  • a

    Which plastic is the most widely used packaging material for drug products

    a) high density polyethylene (HDPE)

    b) low density polyethylene (LDPE)

    c) Polyproylene

    d) Polyvinyl chloride

  • b

    Which plastic is the material of choice for liquid dispensing applications?

    a) high density polyethylene (HDPE)

    b) low density polyethylene (LDPE)

    c) Polyproylene

    d) Polyvinyl chloride

  • c

    Which plastic is good for medical device applications?

    a) high density polyethylene (HDPE)

    b) low density polyethylene (LDPE)

    c) Polyproylene

    d) Polyvinyl chloride

  • closure

    What is the most vulnerable & critical component of a container?

  • closure liners

    -provide a gasket or seal to eliminate leaks by overcoming the minor imperfections between the container and closure

  • metal tube

    -interior must be lined with wax-type formulation or resin solution to protect product from the metal

  • plastic tube

    -LDPE, HDPE, or PP

    -lined with other materials to improve barrier qualities

  • laminated

    - consists of layers of plastic, paper, foil

  • functional packaging

    -packaging that contains and delivers drug directly to the patient

    -pre- filled syringes, injector systems, transdermal patches

  • overt tamper

    -packaging system which must be cut or torn to open the container and remove the product

  • a

    Which plastic has a poor barrier against gases?

    a) high density polyethylene (HDPE)

    b) low density polyethylene (LDPE)

    c) Polyproylene

    d) Polyvinyl chloride

  • a

    What kind of plastic is Tyvek?

    a) polyetylene

    c) Polyproylene

    d) Polyvinyl chloride

  • c

    Which plastic is an effective barrier against gas, vapor, and moisture?

    a) high density polyethylene (HDPE)

    b) low density polyethylene (LDPE)

    c) Polyproylene

    d) Polyvinyl chloride

  • d

    Which plastic is used for iv bags and tubing?

    a) high density polyethylene (HDPE)

    b) low density polyethylene (LDPE)

    c) Polyproylene

    d) Polyvinyl chloride

  • a

    Which material is the most impermeable of the tube materials?

    a) metal

    b) plastic

    c) laminated

  • b

    Which blister packaging is the most protective?

    a) polyvinyl chloride

    b) aluminum

    c) Aclar

    d) Cycloolefine copolymer

  • a

    Which blistering packaging is the cheapest to produce?

    a) polyvinyl chloride

    b) aluminum

    c) Aclar

    d) Cycloolefine copolymer

  • c

    Which blistering packaging has the highest moisture barrier?

    a) polyvinyl chloride

    b) aluminum

    c) Aclar

    d) Cycloolefine copolymer

  • d

    Which blistering packaging has outstanding transparency?

    a) polyvinyl chloride

    b) aluminum

    c) Aclar

    d) Cycloolefine copolymer