Opioid peptides

2017-08-01T17:47:00+03:00[Europe/Moscow] en true Deltorphin, Nociceptin, Morphiceptin, Hemorphin-4, Spinorphin, Dermorphin, Met-enkephalin, Dynorphin A, Difelikefalin, Opiorphin, Dynorphin, Gliadorphin, DAMGO, Enkephalin, Beta-Endorphin, Leu-enkephalin, Endorphins, Cytochrophin-4, Opioid peptide, CR665, Frakefamide, Metkefamide, Casokefamide, Valorphin, Amidorphin, TRIMU 5, DADLE, Zyklophin, Adrenorphin, Alpha-Endorphin, Alpha-Neoendorphin, Beta-Neoendorphin, Dynorphin B, Gamma-Endorphin, Leumorphin flashcards Opioid peptides
Click to flip
  • Deltorphin
    Deltorphin, also known as deltorphin A and dermenkephalin, is a naturally occurring, exogenous opioid heptapeptide and thus, exorphin, with the amino acid sequence Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2.
  • Nociceptin
    Nociceptin/orphanin FQ (N/OFQ), a 17-amino acid neuropeptide, is the endogenous ligand for the nociceptin receptor (NOP, ORL-1), and initiates its function to act on numerous brain activities such as pain sensation and fear learning.
  • Morphiceptin
    Morphiceptin is a tetrapeptide (Tyr-Pro-Phe-Pro-NH2) that is a selective μ-opioid receptor agonist.
  • Hemorphin-4
    Hemorphin-4 is an endogenous opioid peptide of the hemorphin family which possesses antinociceptive properties and is derived from the β-chain of hemoglobin in the bloodstream.
  • Spinorphin
    Spinorphin is an endogenous, non-classical opioid peptide of the hemorphin family first isolated from the bovine spinal cord (hence the prefix spin-) and acts as a regulator of the enkephalinases, a class of enzymes that break down endogenous the enkephalin peptides.
  • Dermorphin
    Dermorphin is a hepta-peptide first isolated from the skin of South American frogs belonging to the genus Phyllomedusa.
  • Met-enkephalin
    Met-enkephalin, also known as metenkefalin (INN), sometimes referred to as opioid growth factor (OGF), is a naturally occurring, endogenous opioid peptide that has opioid effects of a relatively short duration.
  • Dynorphin A
    Dynorphin A is a form of dynorphin and an endogenous opioid peptide with the amino acid sequence: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys.
  • Difelikefalin
    Difelikefalin (INN) (developmental code names CR845, FE-202845), also known as D-Phe-D-Phe-D-Leu-D-Lys-[γ-(4-N-piperidinyl)amino carboxylic acid] (as the acetate salt), is an analgesic opioid peptide acting as a peripherally specific, highly selective agonist of the κ-opioid receptor (KOR).
  • Opiorphin
    Opiorphin is an endogenous chemical compound first isolated from human saliva.
  • Dynorphin
    Dynorphins (Dyn) are a class of opioid peptides that arise from the precursor protein prodynorphin.
  • Gliadorphin
    Gliadorphin (also known as gluteomorphin) is an opioid peptide that is formed during digestion of the gliadin component of the gluten protein.
  • DAMGO
    DAMGO ([D-Ala2, N-MePhe4, Gly-ol]-enkephalin) is a synthetic opioid peptide with high μ-opioid receptor specificity.
  • Enkephalin
    An enkephalin (occasionally spelt encephalin) is a pentapeptide involved in regulating nociception in the body.
  • Beta-Endorphin
    β-Endorphin is an endogenous opioid neuropeptide found in the neurons of both the central and peripheral nervous system.
  • Leu-enkephalin
    Leu-enkephalin is an endogenous opioid peptide neurotransmitter with the amino acid sequence Tyr-Gly-Gly-Phe-Leu that is found naturally in the brains of many animals, including humans.
  • Endorphins
    Endorphins (contracted from "endogenous morphine") are endogenous opioid neuropeptides in humans and other animals.
  • Cytochrophin-4
    Cytochrophin-4 is an opioid peptide.
  • Opioid peptide
    Opioid peptides are short sequences of amino acids that bind to opioid receptors in the brain; opiates and opioids mimic the effect of these peptides.
  • CR665
    CR665 (H-D-Phe-D-Phe-D-Nle-D-Arg-NH-4-Picolyl), also known by the previous developmental code names FE-200665 and JNJ-38488502, is an all D-amino acid peptide that acts as a peripherally restricted κ-opioid receptor agonist.
  • Frakefamide
    Frakefamide (INN) is a synthetic, fluorinated opioid tetrapeptide with the amino acid sequence Tyr-D-Ala-(p-F)Phe-Phe-NH2 which acts as a peripherally-specific, selective μ-opioid receptor agonist.
  • Metkefamide
    Metkefamide (INN; LY-127,623), or metkephamid acetate (USAN), but most frequently referred to simply as metkephamid, is a synthetic opioid pentapeptide and derivative of [Met]enkephalin with the amino acid sequence Tyr-D-Ala-Gly-Phe-(N-Me)-Met-NH2.
  • Casokefamide
    Casokefamide (INN), also known as β-casomorphin 4027 (β-CM-4027) and [D-Ala2,4,Tyr5]-β-casomorphin-5-amide, is a peripherally-specific, synthetic opioid pentapeptide with the amino acid sequence Tyr-D-Ala-Phe-D-Ala-Tyr-NH2.
  • Valorphin
    Valorphin, also known as VV-hemorphin-5, is a naturally occurring, endogenous opioid heptapeptide of the hemorphin family with the amino acid sequence H-Val-Val-Tyr-Pro-Trp-Thr-Gln-OH.
  • Amidorphin
    Amidorphin is an endogenous, C-terminally amidated, opioid peptide generated as a cleavage product of proenkephalin A that is widely distributed in the mammalian brain, with particularly high concentrations found in the adrenal medulla, posterior pituitary, and striatum.
  • TRIMU 5
    TRIMU 5 is a selective agonist of the mu opioid receptor type 2.
  • DADLE
    DADLE ([D-Ala2, D-Leu5]-Enkephalin) is a synthetic opioid peptide with analgesic properties.
  • Zyklophin
    Zyklophin is a semisynthetic peptide derived from dynorphin A and a highly selective antagonist of the κ-opioid receptor (KOR).
  • Adrenorphin
    Adrenorphin, also sometimes referred to as metorphamide, is an endogenous, C-terminally amidated, opioid octapeptide (Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2) that is produced from proteolytic cleavage of proenkephalin A and is widely distributed throughout the mammalian brain.
  • Alpha-Endorphin
    α-Endorphin is an endogenous opioid peptide with a length of 16 amino acids, and the amino acid sequence: Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr.
  • Alpha-Neoendorphin
    α-Neoendorphin is an endogenous opioid peptide with a decapeptide structure and the amino acid sequence Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Lys.
  • Beta-Neoendorphin
    β-Neoendorphin is an endogenous opioid peptide with a nonapeptide structure and the amino acid sequence Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro.
  • Dynorphin B
    Dynorphin B, also known as rimorphin, is a form of dynorphin and an endogenous opioid peptide with the amino acid sequence Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr.
  • Gamma-Endorphin
    γ-Endorphin is an opioid peptide that is characterized by the presence of 17 amino acids.
  • Leumorphin
    Leumorphin, also called dynorphin B-29, is a naturally occurring, endogenous opioid peptide.