Hosam Mohamed-
d
A low Aspirin dose is used for _________.
a) anti-inflammatory effect
b) antipyretic
c) analgesic effect
d) reducing platelet aggregation
-
b,c
An intermediate Aspirin dose is used for __________.
a) anti-inflammatory effect
b) antipyretic
c) analgesic effect
d) reducing platelet aggregation
-
a
A high Aspirin dose is used for _______.
a) anti-inflammatory effect
b) antipyretic
c) analgesic effect
d) reducing platelet aggregation
-
Reye's Syndrome
- rare, but serious syndrome of rapid liver degeneration and
encephalopathy
-
inhibit platelet aggregation
The Nonacetylated Salicylates are effective analgesics & anti-
inflammatories but do NOT ___________.
-
back pain relief
What is the primary use for Nonacetylated Salicylates?
-
b
Which is contraindicated in those susceptible to bronchospasms from NSAIDs?
a) Naproxen
b) Ibuprofen
c) Diclofenac
d) Indomethacin
-
b
Which has a dose-dependent effect on inflammation? (Higher-doses)
a) Naproxen
b) Ibuprofen
c) Diclofenac
d) Indomethacin
-
ibuprofen; antagonizes platelet inhibition
Which NSAID should not be used with Aspirin? Why?
-
aspirin 1 hr before or 8 hr after
If a patient wants to take Aspirin & Ibuprofen together, what time periods is it permissible?
-
a
Which can be used for RA?
a) Naproxen
b) Ibuprofen
c) Diclofenac
d) Indomethacin
-
a
Which is one of the safest NSAIDs?
a) Naproxen
b) Ibuprofen
c) Diclofenac
d) Indomethacin
-
false
Naproxen is a very potent COX-inhibitor. T/F?
-
b
Which has worse GI bleeds?
a) Ibuprofen
b) Naproxen
-
a
Which has a longer DoA?
a) Naproxen
b) Ibuprofen
-
c
Which can be used topically, patch, or opthalmic?
a) Naproxen
b) Ibuprofen
c) Diclofenac
d) Indomethacin
-
very potent; short
Diclofenac is a _________ NSAID, but has a ________ half-life.
-
c
Which increases liver enzymes the most?
a) Naproxen
b) Ibuprofen
c) Diclofenac
d) Indomethacin
-
c
Which can cause serious bleeding and CV events after MI?
a) Naproxen
b) Ibuprofen
c) Diclofenac
d) Indomethacin
-
d
Which inhibits PLA and PLC decreasing lymphocytes?
a) Naproxen
b) Ibuprofen
c) Diclofenac
d) Indomethacin
-
d
Which has the greatest toxicity?
a) Naproxen
b) Ibuprofen
c) Diclofenac
d) Indomethacin
-
strong GI effects, pancreatitis, headache
What are the AEs associated with Indomethacin? (3)
-
d
Which has the highest GI bleed risk?
a) Nabumetone
b) Ketoprofen
c) Flurbiprofen
d) Ketorolac
-
b
Which can inhibit the LOX enzyme (leukotriene synthesis)?
a) Nabumetone
b) Ketoprofen
c) Flurbiprofen
d) Ketorolac
-
c
Which can inhibit TNF & NOS?
a) Nabumetone
b) Ketoprofen
c) Flurbiprofen
d) Ketorolac
-
a
Which requires high daily doses & is expensive?
a) Nabumetone
b) Ketoprofen
c) Flurbiprofen
d) Ketorolac
-
a
Which is a prodrug?
a) Nabumetone
b) Ketoprofen
c) Flurbiprofen
d) Ketorolac
-
a
Which is the least damaging to the stomach?
a) Nabumetone
b) Ketoprofen
c) Flurbiprofen
d) Ketorolac
-
c
Which is mildly uricosuric, therefore it can be used for gout?
a) Piroxicam
b) Meloxicam
c) Oxaprozin
d) Celecoxib
-
a
Which can inhibit neutrophil migration and decrease ROS formation?
a) Piroxicam
b) Meloxicam
c) Oxaprozin
d) Celecoxib
-
a
Which has the highest risk of peptic ulcers and bleeding risk?
a) Piroxicam
b) Meloxicam
c) Oxaprozin
d) Celecoxib
-
b
Which inhibits COX-1 & COX-2?
a) Piroxicam
b) Meloxicam
c) Oxaprozin
d) Celecoxib
-
COX-1 produces TXA2 which causes platelet aggregation; production will shift to this since COX-2 is inhibited
Why do selective inhibitors of COX-2 have the highest risk of thrombotic
events?
-
d
Which can cause rashes due to a sulfonamide component?
a) Piroxicam
b) Meloxicam
c) Oxaprozin
d) Celecoxib
-
COX-3; anti-inflammatory activity
Acetaminophen inhibits ______; therefore it lacks __________.
-
N-acetylcysteine
What is the antidote for Acetaminophen toxicity?
-
false; not an NSAID
Acetaminophen is a selective NSAID. T/F?
-
pain; fever
COX-3 is responsible for causing _______ & _______.
-
aspirin, naproxen, ibuprofen, indomethacin, ketorolac
Which NSAIDs are Nonselective? (5)
-
etodolac, nabumetone, diclofenac, meloxicam
Which NSAIDs are Partially Selective? (4)
-
c
Which drug is equal to Celecoxib in COX-2 inhibition?
a) Naproxen
b) Ibuprofen
c) Diclofenac
d) Indomethacin
