2023-02-11T21:43:22+03:00[Europe/Moscow] en true <p>allergic to penicillin &amp; cephalosporin</p>, <p>contains single mono ring; doesn't bind with body proteins associated w penicillin allergies</p>, <p>KES; Pseudomonas , Gm +</p>, <p>ceftazidime </p>, <p>a,c,d </p>, <p>to prevent metabolism so the patient can reach therapeutic concentrations ; DHP-1</p>, <p>this is a polar group that increases gm (-) porin penetration; increases stability to b-lactamases; thienamycin </p>, <p>rash, high doses can cause seizures, 50% cross-allergenic with pens</p>, <p>imipenem, cilastatin, relebactam</p>, <p>complicated: uti, intra-abdominal infections</p>, <p>carbapenems strong induce bacteria to produce b-lactamases</p>, <p>stability to DHP-1; no need for cilastatin</p>, <p>Meropenem + Vaboractam</p>, <p>new non-suicidal b-lactamase inhibitor</p>, <p>complicated uti</p>, <p>a</p>, <p>imipenem, meropenem, vabomere, ertapenem, doripenem</p>, <p>d</p>, <p>c</p>, <p>Cephalosporins dose is reduced more</p>, <p>c</p>, <p>d</p>, <p>passes through gm- cell wall via passive &amp; active diffusion due to siderophore structure and gm- need for iron. </p>, <p>resistant to all known b-lactamases; porin channel deletion, efflux- pump up-regulation</p>, <p>Fetroja</p>, <p>PBP 2 &amp; 1B</p> flashcards
Monobactam, Carbapenems, & Siderophores

Monobactam, Carbapenems, & Siderophores

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  • allergic to penicillin & cephalosporin

    Aztreonam is used in patients who are what?

  • contains single mono ring; doesn't bind with body proteins associated w penicillin allergies

    What is unique about Aztreonam's structure?

  • KES; Pseudomonas , Gm +

    Aztreonam is used for moderate/severe _____ infections, also active against _______. Not active against ________.

  • ceftazidime

    What Cephalosporin side chain does Aztreonam contain?

  • a,c,d

    Which are broad-spectrum antibiotics with resistance to anaerobes?

    a) Recarbio

    b) Aztreonam

    c) Imipenem

    d) Meropenem

  • to prevent metabolism so the patient can reach therapeutic concentrations ; DHP-1

    Why is Cilastatin added to Imipenem? What enzyme does it inhibit?

  • this is a polar group that increases gm (-) porin penetration; increases stability to b-lactamases; thienamycin

    This is the structure of Imipenem. a) What is the structure the first arrow points to responsible for?b) How does this lack of sulfur &amp; reversed configuration assist this drug molecule?c) Which species is this developed from?

    This is the structure of Imipenem.

    a) What is the structure the first arrow points to responsible for?

    b) How does this lack of sulfur & reversed configuration assist this drug molecule?

    c) Which species is this developed from?

  • rash, high doses can cause seizures, 50% cross-allergenic with pens

    AE associated with Imipenem?

  • imipenem, cilastatin, relebactam

    Recarbio is a combination of what drug molecules?

  • complicated: uti, intra-abdominal infections

    Recarbio is used to treat what?

  • carbapenems strong induce bacteria to produce b-lactamases

    What is a strong reason why we should consider penicillins and cephalosporins before carbapenems?

  • stability to DHP-1; no need for cilastatin

    Meropenem's altered side-chain allows for what?

  • Meropenem + Vaboractam

    What are the drug molecules that make up Vabomere?

  • new non-suicidal b-lactamase inhibitor

    What is unique about Vabomere's MOA?

  • complicated uti

    Vabomere is used to treat _________ in patients 18 years of age and older.

  • a

    Which carbapenem is not stable to DHP-1 and requires cilastatin?

    a) imipenem

    b) meropenem

    c) ertapenem

    d) doripenem

  • imipenem, meropenem, vabomere, ertapenem, doripenem

    What are our Carbapenems?

  • d

    Which Carbapenem can be used against some resistant strains of hospital-acquired Pseudomonas?

    a) imipenem

    b) meropenem

    c) ertapenem

    d) doripenem

  • c

    Which Carbapenem do we NOT use against Pseudomonas?

    a) imipenem

    b) meropenem

    c) ertapenem

    d) doripenem

  • Cephalosporins dose is reduced more

    In general, when it comes to dose restrictions based on kidney failure; how do Cephalosporins compare to Carbapenems?

  • c

    Which Carbapenem has a long half life?

    a) imipenem

    b) meropenem

    c) ertapenem

    d) doripenem

  • d

    Which Carbapenem has a short half life?

    a) imipenem

    b) meropenem

    c) ertapenem

    d) doripenem

  • passes through gm- cell wall via passive & active diffusion due to siderophore structure and gm- need for iron.

    Fetroja MOA?

  • resistant to all known b-lactamases; porin channel deletion, efflux- pump up-regulation

    Fetroja resistance?

  • Fetroja

    -used for MDR gm (-) pseudomonas, acinetobacter baumannii, MDR-KES, Hospital-acquired pneumonia, and ventilator-associated bacterial pneumonia.

  • PBP 2 & 1B

    The Carbapenam nucleus binds to ______ and _____ in Enterobacteria and Pseudomonas aerguinosa.