2025-01-15T05:08:26+03:00[Europe/Moscow] en true <p>tegaserod, prucalopride </p>, <p>5HT-4 agonists; releases acetylcholine; causing peristalsis to occur</p>, <p>b,d</p>, <p>plecanatide, linaclotide, tenapanor, lubipristone</p>, <p>severe diarrhea/dehydration </p>, <p>e</p>, <p>f</p>, <p>poorly absorbable carbs that increase osmotic load/bacterial growth in the gut</p>, <p>recurrent abdominal pain/discomfort &gt;=1x per week in last 3 months with &gt;=2 of the following: relieved with defecation, change in frequency, change in appearance</p>, <p>IBS-C in women &lt;65 yo</p>, <p>b</p>, <p>tegaserod, lubirpristone</p>, <p>b</p>, <p>Chronic idiopathic constipation </p>, <p>a,c</p>, <p>methylcellulose, psyllium, polycarbophil </p>, <p>PEG, lactulose, magnesium hydroxide, sorbitol, glycerin </p>, <p>senna, bisacodyl </p>, <p>stool softener </p>, <p>hyoscyamine, dicyclomine, Librax, Donnatal </p>, <p>inhibits NHE3 transporter in small intestine; reduces sodium absorption, increasing water secretion into lumen </p>, <p>agonists of guanylate cyclase c-receptors on intestinal epithelium; increasing fluid secretion into lumen</p>, <p>activates type 2 cl channels of epithelial cells; increasing cl/water secretion in the intestinal lumen </p>, <p>a</p>, <p>b</p>, <p>beans/legumes, wheat, dairy products w/lactose, high fructose corn syrup, artificial sweeteners, some fruits/veggies </p>, <p>c</p>, <p>e</p>, <p>d</p> flashcards
IBS-C

IBS-C

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  • tegaserod, prucalopride

    Which drugs act on Serotonin-4 receptors? (2)

  • 5HT-4 agonists; releases acetylcholine; causing peristalsis to occur

    Serotonin 4-agonist MOA?

  • b,d

    Which drugs have a BBW for suicidal ideation?

    a) Plecainatide

    b) Tegaserod

    c) Linaclotide

    d) Prucalopride

    e) Lubipristone

    f) Tenapanor

  • plecanatide, linaclotide, tenapanor, lubipristone

    What are the Intestinal Secretagogues? (4)

  • severe diarrhea/dehydration

    What is the BBW associated with Intestinal Secretagogues?

  • e

    Which drug activates Chloride receptors directly?

    a) Plecainatide

    b) Tegaserod

    c) Linaclotide

    d) Prucalopride

    e) Lubipristone

    f) Tenapanor

  • f

    Which drug inhibits sodium reabsorption?

    a) Plecainatide

    b) Tegaserod

    c) Linaclotide

    d) Prucalopride

    e) Lubipristone

    f) Tenapanor

  • poorly absorbable carbs that increase osmotic load/bacterial growth in the gut

    What are FODMAPS, and how do they impact IBS-C?

  • recurrent abdominal pain/discomfort >=1x per week in last 3 months with >=2 of the following: relieved with defecation, change in frequency, change in appearance

    What is the ROME IV Criteria for IBS? (4)

  • IBS-C in women <65 yo

    What is the indication for Tegaserod?

  • b

    Which has a Boxed Warning for major CV events?

    a) Plecainatide

    b) Tegaserod

    c) Linaclotide

    d) Prucalopride

    e) Lubipristone

    f) Tenapanor

  • tegaserod, lubirpristone

    Which medications ONLY have IBS-C indications in women? (2)

  • b

    Which can be used in men with OIC?

    a) Tegaserod

    b) Lubipristone

  • Chronic idiopathic constipation

    What is the indication for Prucalopride?

  • a,c

    Which act on GC-C?

    a) Plecainatide

    b) Tegaserod

    c) Linaclotide

    d) Prucalopride

    e) Lubipristone

    f) Tenapanor

  • methylcellulose, psyllium, polycarbophil

    What are the bulk-forming laxatives? (3)

  • PEG, lactulose, magnesium hydroxide, sorbitol, glycerin

    What are the Osmotic Laxatives? (5)

  • senna, bisacodyl

    What are the stimulant laxatives? (2)

  • stool softener

    Docusate is a _________.

  • hyoscyamine, dicyclomine, Librax, Donnatal

    What are the antispasmodics? (4)

  • inhibits NHE3 transporter in small intestine; reduces sodium absorption, increasing water secretion into lumen

    Tenapanor MOA?

  • agonists of guanylate cyclase c-receptors on intestinal epithelium; increasing fluid secretion into lumen

    GC-C agonists MOA?

  • activates type 2 cl channels of epithelial cells; increasing cl/water secretion in the intestinal lumen

    Lubiprostone MOA?

  • a

    Increased serotonin =

    a) diarrhea

    b) constipation

  • b

    Decreased serotonin =

    a) diarrhea

    b) constipation

  • beans/legumes, wheat, dairy products w/lactose, high fructose corn syrup, artificial sweeteners, some fruits/veggies

    What are some foods to avoid when on a low-FODMAPS diet? (6)

  • c

    Which should be taken >=30 min before meals for best absorption?

    a) Plecainatide

    b) Tegaserod

    c) Linaclotide

    d) Prucalopride

    e) Lubipristone

    f) Tenapanor

  • e

    Which should be taken with food & water?

    a) Plecainatide

    b) Tegaserod

    c) Linaclotide

    d) Prucalopride

    e) Lubipristone

    f) Tenapanor

  • d

    Which should be taken at the same time each day for the best results?

    a) Plecainatide

    b) Tegaserod

    c) Linaclotide

    d) Prucalopride

    e) Lubipristone

    f) Tenapanor