2023-12-07T04:13:27+03:00[Europe/Moscow] en true <p>lose weight, stay hydrated, smoking cessation, exercise, healthy diet</p>, <p>organ meats (liver, kidney), sweet bread, high fructose corn syrup, alcohol overuse(avoid in periods of frequent gout attacks )</p>, <p>2 or more gout attacks, &gt; 1 tophus, CKD stage 2, history of urolithiasis </p>, <p>maintain concentration of 6mg/dL; below 5mg/dl is preferred </p>, <p>false; can be started if anti-inflammatory prophylaxis has started </p>, <p>probenecid, losartan, fenofibrate</p>, <p>xanthine oxidase inhibitors </p>, <p>combination therapy + uricosuric agent </p>, <p>severe cases when patient can't tolerate/not responding to other meds</p>, <p>allopurinol, febuxostat, pegloticase </p>, <p>probenecid </p>, <p>b</p>, <p>d</p>, <p>impaired renal function (CrCl &lt;50ml/min), overproducers of uric acid</p>, <p>maintain urine flow, alkalize urine during first few days </p>, <p>2 gm</p>, <p>d</p>, <p>c</p>, <p>bi-weekly infusions, administer over no less than 2 hours, pretreatment with antihistamines/corticosteroids </p>, <p>fenofibrate or losartan + XO inhibitor </p>, <p>low dose colchicine + low dose NSAID </p>, <p>3 months after achieving uric acid levels or 6 months total </p>, <p>every 2-5 weeks until target achieved; every 6 months after </p> flashcards
Hyperuricemia (Therapeutics)

Hyperuricemia (Therapeutics)

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  • lose weight, stay hydrated, smoking cessation, exercise, healthy diet

    What are the non-pharmacological treatments for Hyperuricemia? (5)

  • organ meats (liver, kidney), sweet bread, high fructose corn syrup, alcohol overuse(avoid in periods of frequent gout attacks )

    Which foods should patients with Hyperuricemia avoid? (4)

  • 2 or more gout attacks, > 1 tophus, CKD stage 2, history of urolithiasis

    What patient factors does ACR recommend Urate Lowering Therapy (ULT) for? (4)

  • maintain concentration of 6mg/dL; below 5mg/dl is preferred

    What is the goal serum uric acid concentration for ULT?

  • false; can be started if anti-inflammatory prophylaxis has started

    ULT cannot be initiated during acute gout attacks. T/F?

  • probenecid, losartan, fenofibrate

    What are the uricosuric agents?

  • xanthine oxidase inhibitors

    ________ are recommended as 1st-line therapies.

  • combination therapy + uricosuric agent

    What is the treatment for refractory cases?

  • severe cases when patient can't tolerate/not responding to other meds

    When is Pegloticase recommended?

  • allopurinol, febuxostat, pegloticase

    Which medications are used for overproducers AND under-excretors? (3)

  • probenecid

    Which medication is used for under-excretors?

  • b

    Which is 1st line?

    a) febuxostat

    b) allopurinol

    c) pegloticase

    d) probenecid

  • d

    Which one should NOT be used in patients with a history of kidney stones?

    a) febuxostat

    b) allopurinol

    c) pegloticase

    d) probenecid

  • impaired renal function (CrCl <50ml/min), overproducers of uric acid

    Probenecid Contraindications? (2)

  • maintain urine flow, alkalize urine during first few days

    How can we prevent kidney stone formation in patients on Probenecid? (2)

  • 2 gm

    What is the maximum dose of Probenecid?

  • d

    Which should be avoided with Salicylates?

    a) febuxostat

    b) allopurinol

    c) pegloticase

    d) probenecid

  • c

    Which is the agent of last resort?

    a) febuxostat

    b) allopurinol

    c) pegloticase

    d) probenecid

  • bi-weekly infusions, administer over no less than 2 hours, pretreatment with antihistamines/corticosteroids

    Pegloticase dosing instructions? (3)

  • fenofibrate or losartan + XO inhibitor

    ACR guidelines for patients with refractory disease?

  • low dose colchicine + low dose NSAID

    What is the 1st line-ACR prophylactic treatments?

  • 3 months after achieving uric acid levels or 6 months total

    How long does prophylactic treatment last?

  • every 2-5 weeks until target achieved; every 6 months after

    If a patient is doing ULT therapy, how often do we check their Uric Acid levels?