Hosam Mohamed-
lower
Metals are more soluble at _____ pHs.
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interactions with essential metals, metal protein complex, exposed subject
What are factors that impact the toxicity of metals? (3)
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ca; ca-dependent neurotransmitter release
Lead can replace _______ in bone and interfere with _________ release.
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a
Which metal has no useful purpose in humans.
a) lead
b) arsenic
c) mercury
d) iron
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b
Which metal can be used to treat cancer & syphillis?
a) lead
b) arsenic
c) mercury
d) iron
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b
Which metal is bound to skin, hair, and nails?
a) lead
b) arsenic
c) mercury
d) iron
-
b
Which metal is metabolized undergoes methylation in the liver & excreted in the urine?
a) lead
b) arsenic
c) mercury
d) iron
-
india; bangladesh
Arsenic is a public health crisis in _____ & _____.
-
blood
In order to determine lead exposure duration you must confirm with a ______ test.
-
encephalopathy, neurocognitive defects
Major clinical effects of lead toxicity? (2)
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capillaries, GI tract, liver, erythrocytes
What are the target organs for Arsenic poisoning? (3)
-
b
Which metal can cause gastroenteritis, encephalopathy, pancytopenia, and arrhythmic shock?
a) lead
b) arsenic
c) mercury
d) iron
-
hyperpigmentation
Chronic Arsenic exposure can lead to ________.
-
c
Which metal is liquid at room temperature?
a) lead
b) arsenic
c) mercury
d) iron
-
c
Which metal can cause Acrodynia (pink hands and feet)?
a) lead
b) arsenic
c) mercury
d) iron
-
d
Which metal has vast uses for humans and is an essential element in the body?
a) lead
b) arsenic
c) mercury
d) iron
-
chelators
-Prevent or reverse the toxic effects of a heavy metal on an enzyme or other cellular target; Accelerate the elimination of a metal from the body
-
b,c
Which chelator can be used orally or IV?
a) dimercaprol
b) succimer
c) unithiol
d) penicillamine
e) EDTA
f) Defroxamine
-
a
Which chelator is lipophilic and can cause several adverse events?
a) dimercaprol
b) succimer
c) unithiol
d) penicillamine
e) EDTA
f) Defroxamine
-
b
Which chelator can cause skin rashes?
a) dimercaprol
b) succimer
c) unithiol
d) penicillamine
e) EDTA
f) Defroxamine
-
c
Which chelator can cause vasodilation and hypotension with rapid IV infusion?
a) dimercaprol
b) succimer
c) unithiol
d) penicillamine
e) EDTA
f) Defroxamine
-
d
Which chelator is used to treat copper poisoning?
a) dimercaprol
b) succimer
c) unithiol
d) penicillamine
e) EDTA
f) Defroxamine
-
d
Which chelator can cause nephrotoxicity and autoimmune dysfunction?
a) dimercaprol
b) succimer
c) unithiol
d) penicillamine
e) EDTA
f) Defroxamine
-
e
Which chelator is given IV ONLY with calcium disodium salt to prevent hypocalcemia?
a) dimercaprol
b) succimer
c) unithiol
d) penicillamine
e) EDTA
f) Defroxamine
-
f
Which chelator is used to treat iron poisoning?
a) dimercaprol
b) succimer
c) unithiol
d) penicillamine
e) EDTA
f) Defroxamine
-
f
Which chelator can cause neurotoxicity, hepatic, and renal dysfunction if used long term?
a) dimercaprol
b) succimer
c) unithiol
d) penicillamine
e) EDTA
f) Defroxamine
-
b
Which organ is quickly impacted by iron toxicity?
a) lung
b) liver
c) kidneys
d) heart
-
c
Which metal is absorbed via inhalation?
a) lead
b) arsenic
c) mercury
d) iron
-
a,b,c,d
Which is a Bidentate chelator?
a) dimercaprol
b) succimer
c) unithiol
d) penicillamine
e) EDTA
f) Defroxamine
-
e,f
Which is a Polydentate chelator?
a) dimercaprol
b) succimer
c) unithiol
d) penicillamine
e) EDTA
f) Defroxamine
