General anesthetics

γ-Hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid, is a naturally occurring neurotransmitter and a psychoactive drug.

Sodium thiopental, also known as Sodium Pentothal (a trademark of Abbott Laboratories, not to be confused with pentobarbital), thiopental, thiopentone, or Trapanal (also a trademark), is a rapid-onset short-acting barbiturate general anesthetic that is an analogue of thiobarbital.

Hexobarbital or hexobarbitone, sold both in acid and sodium salt forms as Citopan, Evipan, and Tobinal, is a barbiturate derivative having hypnotic and sedative effects.

Propanidid is an ultra short-acting phenylacetate general anesthetic.

Chloroform, or trichloromethane, is an organic compound with formula CHCl3.

Diethyl ether or simply ether, is an organic compound in the ether class with the formula (C2H5)2O.

Ethylene (IUPAC name: ethene) is a hydrocarbon which has the formula C2H4 or H2C=CH2.

Ketamine, sold under the brand name Ketalar among others, is a medication mainly used for starting and maintaining anesthesia.

Nitrous oxide, commonly known as laughing gas, nitrous, nitro, or NOS  is a chemical compound with the formula N2O.

Chloroethane or monochloroethane, commonly known by its old name ethyl chloride, is a chemical compound with chemical formula C2H5Cl, once widely used in producing tetraethyllead, a gasoline additive.

Sulfur hexafluoride (SF6) is an inorganic, colorless, odorless, non-flammable, extremely potent greenhouse gas, which is an excellent electrical insulator.

Fentanyl (also known as fentanil) is a potent, synthetic opioid pain medication with a rapid onset and short duration of action.

Propofol, marketed as Diprivan among others, is a short-acting medication that results in a decreased level of consciousness and lack of memory for events.

The chemical compound trichloroethylene (C2HCl3) is a halocarbon commonly used as an industrial solvent.

1,1,1,2-tetrafluoroethane, R-134a, Forane 134a, Genetron 134a, Florasol 134a, Suva 134a or HFC-134a, also known as norflurane (INN), is a haloalkane refrigerant with thermodynamic properties similar to R-12 (dichlorodifluoromethane) but with insignificant ozone depletion potential and a somewhat lower global warming potential (1300, compared to R-12's GWP of 2400).

Halothane (trademarked as Fluothane) is a general anesthetic that is inhaled.

Enflurane (2-chloro-1,1,2,-trifluoroethyl-difluoromethyl ether) is a halogenated ether.

Isoflurane is a halogenated ether used for inhalational anesthesia.

Methoxyflurane (INN), formerly marketed as Penthrane by Abbott Laboratories, is a halogenated ether that was in clinical use as a volatile inhalational anesthetic from its introduction by Joseph F.

Phencyclidine (PCP), also known as angel dust and Sernyl among others, is a dissociative drug.

Anileridine (trade name: Leritine) is a synthetic analgesic drug and is a member of the piperidine class of analgesic agents developed by Merck & Co.

Etomidate (USAN, INN, BAN) (marketed as Amidate) is a short-acting intravenous anaesthetic agent used for the induction of general anaesthesia and sedation for short procedures such as reduction of dislocated joints, tracheal intubation, and cardioversion.

Narcobarbital (Pronarcon) is a barbiturate derivative developed by Riedel de Hean in the 1930s.

Minaxolone (CCI-12923) is a neuroactive steroid which was developed as a general anesthetic but was withdrawn before registration due to toxicity seen with long-term administration in rats, and hence was never marketed.

Methoxypropane, or methyl propyl ether, is an ether once used as a general anaesthetic.

Alfaxalone (INN, JAN), also known as alphaxalone or alphaxolone (BAN), is a neuroactive steroid and general anaesthetic.

Hydroxydione, as hydroxydione sodium succinate (INN, USAN, BAN) (brand names Viadril, Predion, and Presuren), is a neuroactive steroid which was formerly used as a general anesthetic, but was discontinued due to incidence of thrombophlebitis in patients.

Methohexital or methohexitone (marketed under the brand name Brevital) is a drug which is a barbiturate derivative.

Fospropofol (INN), often used as the disodium salt (trade name Lusedra) is an intravenous sedative-hypnotic agent.

Sufentanil (R30730, brand name Sufenta) is a synthetic opioid analgesic drug approximately five to 10 times more potent than its parent drug, fentanyl, and 500 times as potent as morphine.

Vinyl ether, also known as divinyl ether, divinyl oxide, Vinethene (pharmaceutical trade name) and ethenoxyethene (IUPAC), is a clear, nearly colorless, volatile liquid which was briefly used as an inhalation anesthetic.

Cyclopentobarbital sodium (Cyclopal, Dormisan) is a barbiturate derivative invented in the 1940s.

Secobarbital sodium (marketed by Eli Lilly and Company, and subsequently by other companies as described below, under the brand name Seconal) is a barbiturate derivative drug that was patented in 1934 in the US.

Chloralose is an avicide, and a rodenticide used to kill mice in temperatures below 15 °C.

Fluroxene (INN, USAN; brand name Fluoromar), or 2,2,2-trifluoroethyl vinyl ether, is a volatile, inhalational anesthetic, and was the first halogenated hydrocarbon anesthetic to be introduced.

Propoxate (INN; R7464) is an anesthetic related to etomidate and metomidate that was never marketed.

Alfentanil (R-39209, trade name Alfenta, Rapifen in Australia) is a potent but short-acting synthetic opioid analgesic drug, used for anaesthesia in surgery.

Ketofol is a mixture of ketamine and propofol.

Thiotetrabarbital (INN; Thionarcex) is a drug which is a short-acting barbiturate derivative that is used as an anesthetic.

Desflurane (1,2,2,2-tetrafluoroethyl difluoromethyl ether) is a highly fluorinated methyl ethyl ether used for maintenance of general anesthesia.

Acetylfentanyl (acetyl fentanyl) is an opioid analgesic drug that is an analog of fentanyl.

Metomidate is a non-barbiturate imidazole that was discovered by Janssen Pharmaceutica in 1965 and under the names (Hypnodil, Nokemyl) is sold as a sedative-hypnotic drug used in Europe to treat humans and for veterinary purposes.

Alfaxolone/alfadolone (Althesin) is a short acting intravenous anaesthetic agent.

Remifentanil (marketed by GlaxoSmithKline and Abbott as Ultiva) is a potent, short-acting synthetic opioid analgesic drug.

Sevoflurane (1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)propane; synonym, fluoromethyl hexafluoroisopropyl ether), is a sweet-smelling, nonflammable, highly fluorinated methyl isopropyl ether used as an inhalational anaesthetic for induction and maintenance of general anesthesia.

Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist.

Butyr-fentanyl or butyrylfentanyl (not to be confused with 3-methylfentanyl) is a potent short-acting synthetic opioid analgesic drug.

Pregnanolone, also known as eltanolone (INN), as well as 3α,5β-tetrahydroprogesterone (3α,5β-THP) or 3α-hydroxy-5β-pregnan-20-one, is an endogenous neurosteroid that is biosynthesized from progesterone.

Tricaine mesylate (Tricaine methanesulfonate, TMS, MS-222), is white powder used for anesthesia, sedation, or euthanasia of fish.

Arketamine, also (R)-ketamine or (R)-(−)-ketamine, is the (R)-(−) enantiomer of ketamine.

Esketamine (also (S)-ketamine or S(+)-ketamine) (brand name Ketanest S) is a general anaesthetic and a dissociative.

Norketamine, or N-desmethylketamine, is the major active metabolite of ketamine, which is formed mainly by CYP3A4.

Alfadolone (INN), or alphadolone is a neuroactive steroid and general anesthetic.

Renanolone (INN), or 11-ketopregnanolone, is a semisynthetic neuroactive steroid which was described as a general anesthetic, but was never introduced for clinical use.

Phenoperidine (Operidine or Lealgin), is an opioid used as a general anesthetic.

Buthalital sodium (INN; Bayinal, Baytinal, Thialbutal, Transithal, Ulbreval), or buthalitone sodium (BAN), is a barbiturate derivative which was under development as a short-acting anesthetic.

Methitural (INN; Neraval, Thiogenal), or methitural sodium, also known as methioturiate, is a barbiturate derivative which was marketed in the 1950s in Europe (in Germany and Italy) as an ultra-short-acting intravenous anesthetic.

Aliflurane (INN, USAN, code name Hoechst Compound 26 or 26-P) is a halocarbon drug which was investigated as an inhalational anesthetic but was never marketed.

Halopropane (synonym FHD-3, trade name Tebron) is a halocarbon drug which was investigated as an inhalational anesthetic but was never marketed.

Roflurane (INN, USAN, code name DA-893) is a halocarbon drug which was investigated as an inhalational anesthetic but was never marketed.

Synthane (code name BAX-3224) is a halocarbon agent which was investigated as an inhalational anesthetic but was never marketed.

Teflurane (INN, USAN, code name Abbott 16900) is a halocarbon drug which was investigated as an inhalational anesthetic but was never marketed.