What are the two factors that define the validity of a study?
Internal validity is concerned with the appropriate measurement of ___, ___ and ___.
Internal validity is concerned with the appropriate measurement of exposure, outcome and association between exposure and disease.
A study must have external validity before it can have internal validity. True or false?
False; a study must internal validity before it can have external validity. Internal validity is always the FIRST priority, since invalid findings cannot be generalized.
What are the two categories of error?
Random - rate, odds ratio
Systemic - measurement bias
Name some factors that cause random error.
- poor precision
- sampling error
- variability in measurement
What does precision refer to?
If the measurement/effect is reproducible and consistent over time.
___ helps reduce sampling error.
Increasing sample size
What factors cause systemic error?
- selection bias
- information bias
- confounding
In analytical studies, where does bias come from?
When the comparison groups are not comparable.
Selection bias is due ___.
systematic differences in the characteristics in the study sample and the reference population (not representative). It's likely that the researchers chose the wrong method to capture answers.
What is information bias?
Error in the accuracy of information collected between comparison groups.
How can information bias be minimized?
- use standardized data collection forms
- double blinding
What criteria needs to be satisfied for a factor to be considered a confounder?
1. Be a risk factor for the disease
2. Be associated with the exposure
3. NOT a step in the causal path between exposure and disease
What are prevention strategies for controlling confounding variables?
- randomization
- restriction (ie. restricting a study to women only)
- matching