Enzyme inhibitors

2017-07-30T04:38:03+03:00[Europe/Moscow] en true Orlistat, Clavulanic acid, Aztreonam, Piceatannol, LY294002, Milnacipran, Azelaic acid, Myxothiazol, Wortmannin, 3-Amino-1,2,4-triazole, Abiraterone acetate, Orteronel, Medroxyprogesterone acetate, Fumonisin B1, 3-Benzoxepin, Tipiracil, Fumonisin B2, Seviteronel, Non-competitive inhibition, VNI (molecule), Bifluranol, Saralasin, Calcium carbimide, Levomilnacipran, JNJ-42165279, Galeterone, Uncompetitive inhibitor, Decynium-22, PF-04457845, PF-4800567, AMG319, 3-Nitrooxypropanol, Epostane, AZD3293, 4-Nonylphenylboronic acid, Etomoxir flashcards Enzyme inhibitors
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  • Orlistat
    Orlistat is a drug designed to treat obesity.
  • Clavulanic acid
    Clavulanic acid (rINN) /ˌklævjuːˈlænᵻk ˈæsᵻd/ is a β-lactam drug that functions as a mechanism-based β-Lactamase inhibitor.
  • Aztreonam
    Aztreonam (trade names Azactam injection, Cayston inhalation) is a monobactam antibiotic used primarily to treat infections caused by gram-negative bacteria.
  • Piceatannol
    Piceatannol is a stilbenoid, a type of phenolic compound.
  • LY294002
    LY294002 is a morpholine-containing chemical compound that is a potent inhibitor of numerous proteins, and a strong inhibitor of phosphoinositide 3-kinases (PI3Ks).
  • Milnacipran
    Milnacipran (trade names Ixel, Savella, Dalcipran, Toledomin) is a serotonin–norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia.
  • Azelaic acid
    Azelaic acid is an organic compound with the formula (CH2)7(CO2H)2.
  • Myxothiazol
    Myxothiazol (produced by the myxobacterium Myxococcus fulvus) is an inhibitor of the mitochondrial cytochrome bc1 complex (coenzyme Q - cytochrome c reductase).
  • Wortmannin
    Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces wortmannii, is a non-specific, covalent inhibitor of phosphoinositide 3-kinases (PI3Ks).
  • 3-Amino-1,2,4-triazole
    3-Amino-1,2,4-triazole (3-AT) is a heterocyclic organic compound that consists of a 1,2,4-triazole substituted with an amino group.
  • Abiraterone acetate
    Abiraterone acetate (INN, USAN, BAN, JAN) (brand names Zytiga, Abiratas, Abretone, Abirapro) is a steroidal antiandrogen, specifically an androgen synthesis inhibitor, used in combination with prednisone in metastatic castration-resistant prostate cancer (previously called hormone-resistant or hormone-refractory prostate cancer) – i.
  • Orteronel
    Orteronel (TAK-700) is a non-steroidal antiandrogen that was being developed for the treatment of cancer by Takeda Pharmaceutical Company in conjunction with Millennium Pharmaceuticals.
  • Medroxyprogesterone acetate
    Medroxyprogesterone acetate (MPA), sold under the brand name Depo-Provera among others, is a steroidal progestin of the 17α-hydroxyprogesterone group and a synthetic derivative of the progestational steroid hormone progesterone.
  • Fumonisin B1
    Fumonisin B1 is the most prevalent member of a family of toxins, known as fumonisins, produced by several species of Fusarium molds, such as Fusarium verticillioides, which occur mainly in maize (corn), wheat and other cereals.
  • 3-Benzoxepin
    3-Benzoxepin is an annulated ring system with an aromatic benzene ring and a non-aromatic, unsaturated, oxygen-containing seven-membered heterocyclic oxepin.
  • Tipiracil
    Tipiracil is a drug used in the treatment of cancer.
  • Fumonisin B2
    Fumonisin B2 is a fumonisin mycotoxin produced by the fungi Fusarium verticillioides and Fusarium moniliforme.
  • Seviteronel
    Seviteronel (INN; developmental code VT-464) is an experimental cancer treatment for a type of prostate cancer.
  • Non-competitive inhibition
    Non-competitive inhibition is a type of enzyme inhibition where the inhibitor reduces the activity of the enzyme and binds equally well to the enzyme whether or not it has already bound the substrate.
  • VNI (molecule)
    VNI is an experimental drug for treating Chagas disease currently being studied at Vanderbilt University.
  • Bifluranol
    Bifluranol (INN, BAN) (brand name Prostarex) (former developmental code name BX-341) is an non-steroidal estrogen of the stilbestrol group related to diethylstilbestrol that is used as an antiandrogen in the United Kingdom in the treatment of prostate cancer.
  • Saralasin
    Saralasin is a partial agonist of angiotensin II receptors, though it is commonly mistaken as a competitive antagonist.
  • Calcium carbimide
    Calcium carbimide, sold as the citrate salt under the trade name Temposil, is an alcohol sensitizing agent.
  • Levomilnacipran
    Levomilnacipran (brand name Fetzima) is an antidepressant approved in the United States for the treatment of major depressive disorder (MDD) in adults.
  • JNJ-42165279
    JNJ-42165279 is a drug developed by Janssen which acts as a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 70nM.
  • Galeterone
    Galeterone (TOK-001 or VN/124-1) is a novel steroidal antiandrogen under development by Tokai Pharmaceuticals for the treatment of prostate cancer.
  • Uncompetitive inhibitor
    Uncompetitive inhibition, also known as anti-competitive inhibition, takes place when an enzyme inhibitor binds only to the complex formed between the enzyme and the substrate (the E-S complex).
  • Decynium-22
    Decynium-22 is a cation derivative of quinoline, and a potent inhibitor of the plasma membrane monoamine transporter (PMAT), as well as all members of the organic cation transporter (OCT) family in both human and rat cells.
  • PF-04457845
    PF-04457845 is a potent and exquisitely selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 7.
  • PF-4800567
    PF-4800567 is a drug developed by Pfizer which acts as a selective inhibitor of the enzyme Casein kinase 1 epsilon (CK1-ε), and has mainly been used in the study of the casein kinase 1 enzymes in the regulation of circadian rhythm, as well as showing potential neuroprotective effects.
  • AMG319
    AMG319 is a drug developed by Amgen which acts as an inhibitor of the phosphoinositide 3-kinase enzyme subtype PI3Kδ.
  • 3-Nitrooxypropanol
    3-Nitrooxypropanol, abbreviated 3NOP, is an organic compound with the formula HOCH2CH2CH2ONO2.
  • Epostane
    Epostane (INN, USAN, BAN) (developmental code name WIN-32729) is an inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD) that was developed as an contraceptive, abortifacient, and oxytocic drug but was never marketed.
  • AZD3293
    AZD3293, also known as LY3314814 is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor.
  • 4-Nonylphenylboronic acid
    4-Nonylphenylboronic acid is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 9.
  • Etomoxir
    Etomoxir, or 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate, is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane.