Drugs acting on the gastrointestinal system and metabolism

Dicycloverine, also known as dicyclomine, is an anticholinergic that blocks muscarinic receptors.

An anti-diarrhoeal drug (or anti-diarrheal drug in American English) is any medication which provides symptomatic relief for diarrhoea.

Imiglucerase is a medication used in the treatment of Gaucher's disease.

Sulfasalazine (SSZ), marketed under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis.

Ursodeoxycholic acid (INN, BAN and AAN), also known as ursodiol (USAN) and the abbreviation UDCA, from the root-word for bear urso, as bear bile contains the substance, is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria.

Bismuth subsalicylate, sold under the brand name Pepto-Bismol, is an antacid medication used to treat temporary discomforts of the stomach and gastrointestinal tract, such as diarrhea, indigestion, heartburn and nausea.

Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, used to enhance cervical dilation during childbirth.

Teduglutide (brand names Gattex in the US and Revestive in Europe) is a 33-membered polypeptide and glucagon-like peptide-2 (GLP-2) analog that is used for the treatment of short bowel syndrome.

Teprenone (or geranylgeranylacetone) is a pharmaceutical drug used for the treatment of gastric ulcers.

Tenapanor is a drug developed by Ardelyx, which acts as an inhibitor of the sodium-proton exchanger NHE3.

Alicaforsen is an inflammatory bowel disease drug candidate.

Linaclotide (marketed under the trade name Linzess in the US and Mexico, and as Constella in Canada and many other countries) is a peptide agonist of guanylate cyclase 2C.

Ferrous tartrate is a chemical compound and the iron(II) salt of tartaric acid.

Aceglutamide (INN, JAN) (brand name Neuramina), or aceglutamide aluminum (JAN, USAN) (brand name Glumal), also known as acetylglutamine, is a psychostimulant, nootropic, and antiulcer agent that is marketed in Spain and Japan.

Acetoxolone is a drug used for peptic ulcer and gastroesophageal reflux disease.

Carbenoxolone (CBX) is a glycyrrhetinic acid derivative with a steroid-like structure, similar to substances found in the root of the licorice plant.

Gefarnate is a drug used for the treatment of gastric ulcers.

Chlordiazepoxide/clidinium bromide is a drug consisting of chlordiazepoxide and clidinium bromide and used to treat peptic ulcers, irritable bowel syndrome (IBS), and gastritis.

Relamorelin (INN, USAN) (developmental code names RM-131, BIM-28131, BIM-28163) is a synthetic, peptide, centrally penetrant, selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) which is under development by Rhythm Pharmaceuticals for the treatment of diabetic gastroparesis, chronic idiopathic constipation, and anorexia nervosa.

Ulimorelin (INN, USAN) (developmental code name TZP-101) is a drug with a modified cyclic peptide structure which acts as a selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR).

Bromopride (INN) is a dopamine antagonist with prokinetic properties widely used as an antiemetic, closely related to metoclopramide.

Alverine is a drug used for functional gastrointestinal disorders.

Sulglicotide (or sulglycotide) is a drug used for peptic ulcer and gastro-oesophageal reflux disease.

Sofalcone (INN) is an oral gastrointestinal medication used in Japan.

Obeticholic acid (abbreviated to OCA), is a semi-synthetic bile acid analogue which has the chemical structure 6α-ethyl-chenodeoxycholic acid.

Bevenopran (INN, USAN) (former developmental code names CB-5945, ADL-5945, MK-2402, OpRA III) is a peripherally selective μ- and δ-opioid receptor antagonist that was under development by Cubist Pharmaceuticals for the treatment of chronic opioid-induced constipation.

Bismuth subgallate, with a chemical formula C7H5BiO6, is commonly used to treat malodor by deodorizing flatulence and stools.

Axelopran (INN, USAN) (developmental code name TD-1211) is a drug which is under development by Theravance Biopharma for the treatment of opioid-induced constipation.

Benexate (INN) is a drug used in the treatment of acid-related disorders.

Malotilate (INN) is a drug used in the treatment of liver disease.

Eupatilin (5,7-Dihydroxy-3',4',6-trimethoxyflavone) is an O-methylated flavone, a type of flavonoids.

Sucralfate is a medication primarily taken to treat active duodenal ulcers.

Cetraxate (INN) is an oral gastrointestinal medication which has a cytoprotective effect.

Lubiprostone (rINN, marketed under the trade name Amitiza among others) is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation.

Candoxatril is the orally active prodrug of candoxatrilat (UK-73967) human neutral endopeptidase (Neprilysin) as the neutral endopeptidase 24.

Ecadotril is a neutral endopeptidase inhibitor ((NEP) EC 3.4.24.11) and determined by the presence of peptidase family M13 as a neutral endopeptidase inhibited by phosphoramidon.