Drugs acting on the gastrointestinal system and metabolism

An anti-diarrhoeal drug (or anti-diarrheal drug in American English) is any medication which provides symptomatic relief for diarrhoea.

Imiglucerase is a medication used in the treatment of Gaucher's disease.

Bromopride (INN) is a dopamine antagonist with prokinetic properties widely used as an antiemetic, closely related to metoclopramide.

Dicycloverine, also known as dicyclomine, is an anticholinergic that blocks muscarinic receptors.

Ursodeoxycholic acid (INN, BAN and AAN), also known as ursodiol (USAN) and the abbreviation UDCA, from the root-word for bear urso, as bear bile contains the substance, is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria.

Bismuth subsalicylate, sold under the brand name Pepto-Bismol, is an antacid medication used to treat temporary discomforts of the stomach and gastrointestinal tract, such as diarrhea, indigestion, heartburn and nausea.

Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, used to enhance cervical dilation during childbirth.

Sulfasalazine (SSZ), marketed under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis.

Ulimorelin (INN, USAN) (developmental code name TZP-101) is a drug with a modified cyclic peptide structure which acts as a selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR).

Obeticholic acid (abbreviated to OCA), is a semi-synthetic bile acid analogue which has the chemical structure 6α-ethyl-chenodeoxycholic acid.

Acetoxolone is a drug used for peptic ulcer and gastroesophageal reflux disease.

Carbenoxolone (CBX) is a glycyrrhetinic acid derivative with a steroid-like structure, similar to substances found in the root of the licorice plant.

Cetraxate (INN) is an oral gastrointestinal medication which has a cytoprotective effect.

Gefarnate is a drug used for the treatment of gastric ulcers.

Sulglicotide (or sulglycotide) is a drug used for peptic ulcer and gastro-oesophageal reflux disease.

Teprenone (or geranylgeranylacetone) is a pharmaceutical drug used for the treatment of gastric ulcers.

Alicaforsen is an inflammatory bowel disease drug candidate.

Candoxatril is the orally active prodrug of candoxatrilat (UK-73967) human neutral endopeptidase (Neprilysin) as the neutral endopeptidase 24.

Ecadotril is a neutral endopeptidase inhibitor ((NEP) EC 3.4.24.11) and determined by the presence of peptidase family M13 as a neutral endopeptidase inhibited by phosphoramidon.

Lubiprostone (rINN, marketed under the trade name Amitiza among others) is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation.

Alverine is a drug used for functional gastrointestinal disorders.

Teduglutide (brand names Gattex in the US and Revestive in Europe) is a 33-membered polypeptide and glucagon-like peptide-2 (GLP-2) analog that is used for the treatment of short bowel syndrome.

Chlordiazepoxide/clidinium bromide is a drug consisting of chlordiazepoxide and clidinium bromide and used to treat peptic ulcers, irritable bowel syndrome (IBS), and gastritis.

Sucralfate is a medication primarily taken to treat active duodenal ulcers.

Aceglutamide (INN, JAN) (brand name Neuramina), or aceglutamide aluminum (JAN, USAN) (brand name Glumal), also known as acetylglutamine, is a psychostimulant, nootropic, and antiulcer agent that is marketed in Spain and Japan.

Ferrous tartrate is a chemical compound and the iron(II) salt of tartaric acid.

Malotilate (INN) is a drug used in the treatment of liver disease.

Axelopran (INN, USAN) (developmental code name TD-1211) is a drug which is under development by Theravance Biopharma for the treatment of opioid-induced constipation.

Eupatilin (5,7-Dihydroxy-3',4',6-trimethoxyflavone) is an O-methylated flavone, a type of flavonoids.

Tiropramide (INN) is an antispasmodic.

Sofalcone (INN) is an oral gastrointestinal medication used in Japan.

Bismuth subgallate, with a chemical formula C7H5BiO6, is commonly used to treat malodor by deodorizing flatulence and stools.

Linaclotide (marketed under the trade name Linzess in the US and Mexico, and as Constella in Canada and many other countries) is a peptide agonist of guanylate cyclase 2C.

Bevenopran (INN, USAN) (former developmental code names CB-5945, ADL-5945, MK-2402, OpRA III) is a peripherally selective μ- and δ-opioid receptor antagonist that was under development by Cubist Pharmaceuticals for the treatment of chronic opioid-induced constipation.

Tidiacic is a hepatoprotective drug.

Tenapanor is a drug developed by Ardelyx, which acts as an inhibitor of the sodium-proton exchanger NHE3.

Benexate (INN) is a drug used in the treatment of acid-related disorders.

Relamorelin (INN, USAN) (developmental code names RM-131, BIM-28131, BIM-28163) is a synthetic, peptide, centrally penetrant, selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) which is under development by Rhythm Pharmaceuticals for the treatment of diabetic gastroparesis, chronic idiopathic constipation, and anorexia nervosa.

Volixibat (INN; development code SHP626) is a medication under development as a possible treatment for nonalcoholic steatohepatitis (NASH), the most severe form of non-alcoholic fatty liver disease (NAFLD).