2023-11-09T03:49:28+03:00[Europe/Moscow] en true <p>an increase in SCr lags behind kidney injury; delaying diagnosis </p>, <p>excreted Na/ filtered Na x 100 </p>, <p>&gt; 1%</p>, <p>hyperkalemia, hyperphosphatemia, hypocalcemia </p>, <p>hemodynamic support and volume replacement</p>, <p>managing the cause and providing supportive care</p>, <p>removing the cause of the obstruction</p>, <p>increase dose of loop diuretic; loop diuretics + metalozone </p>, <p>a</p>, <p>discontinue drug and other potential nephrotoxins; ensure patient is hydrated</p>, <p>amifostine, antioxidants, hypertonic saline, IV magnesium </p>, <p>plasmaforesis; stop drug/reduce dose + vigorous hydration w NS</p>, <p>activates TNF-a which leads to renal tubular cell death; causes damage to vascular- decreased O2 delivery and cell death</p>, <p>false; it is highly protein bound and requires plasmaphoresis </p>, <p>acetylcysteine, amifostine </p>, <p>a</p>, <p>high BUN, metabolic acidosis, decreased GFR</p>, <p>diabetic; they already have elevated glomerular capillary pressure due to albumin </p>, <p>drink lots of fluids, sodium bicarbonate, ascorbic acid, K-phos OG</p>, <p>rhabdomyolysis </p>, <p>a</p>, <p>b</p>, <p>c</p>, <p>false; high dose to increase perfusion </p>, <p>Ethyol </p>, <p>acid-base abnormalities, electrolyte imbalance, intoxication, fluid overload, uremia</p> flashcards
Drug-Induced AKI, Prevention, & Treatment

Drug-Induced AKI, Prevention, & Treatment

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  • an increase in SCr lags behind kidney injury; delaying diagnosis

    What is the problem with using SCr as a biomarker for AKI?

  • excreted Na/ filtered Na x 100

    FeNa formula?

  • > 1%

    Intrinsic AKI FeNa =

  • hyperkalemia, hyperphosphatemia, hypocalcemia

    What electrolyte abnormalities can occur in AKI? (3)

  • hemodynamic support and volume replacement

    How do we manage/treat Pre-Renal AKI?

  • managing the cause and providing supportive care

    How do we manage/treat Intrinsic AKI?

  • removing the cause of the obstruction

    How do we manage/treat Post-Renal AKI?

  • increase dose of loop diuretic; loop diuretics + metalozone

    How can we manage diuretic resistance in a volume-overloaded patient with AKI?

  • a

    Which would be used in a hemodynamically unstable patient?

    a) continuous RRT

    b) intermittent RRT

  • discontinue drug and other potential nephrotoxins; ensure patient is hydrated

    How is AG induced Tubular Necrosis treated? (2)

  • amifostine, antioxidants, hypertonic saline, IV magnesium

    How can we prevent Cisplatin induced Tubular Necrosis? (4)

  • plasmaforesis; stop drug/reduce dose + vigorous hydration w NS

    How is Cisplatin induced Tubular Necrosis treated? (2)

  • activates TNF-a which leads to renal tubular cell death; causes damage to vascular- decreased O2 delivery and cell death

    How does Cisplatin cause AKI? (2)

  • false; it is highly protein bound and requires plasmaphoresis

    Cisplatin can be removed with dialysis. T/F?

  • acetylcysteine, amifostine

    Which drugs can we use to treat Cisplatin overdose? (2)

  • a

    Which is a prodrug?

    a) amifostine

    b) acetylcysteine

  • high BUN, metabolic acidosis, decreased GFR

    How can Lisinopril cause AKI? (3)

  • diabetic; they already have elevated glomerular capillary pressure due to albumin

    Which patients can we use Lisinopril to treat AKI? Why?

  • drink lots of fluids, sodium bicarbonate, ascorbic acid, K-phos OG

    How can we prevent Indinvair/ Methotrexate crystals from being formed? (4)

  • rhabdomyolysis

    What are elevated levels of creatine kinase indicative of?

  • a

    Which dose targets "dopamine receptors of the kidney"?

    a) 1-3 mcg

    b) 3-10 mcg

    c) > 10

  • b

    Which dose targets beta receptors?

    a) 1-3 mcg

    b) 3-10 mcg

    c) > 10

  • c

    Which dose targets alpha & beta receptors?

    a) 1-3 mcg

    b) 3-10 mcg

    c) > 10

  • false; high dose to increase perfusion

    Renal dose dopamine is recommended in treating AKI. T/F?

  • Ethyol

    Amifostine Brand Name?

  • acid-base abnormalities, electrolyte imbalance, intoxication, fluid overload, uremia

    What are the indications for starting hemodialysis? (5)