2022-09-01T18:24:30+03:00[Europe/Moscow] en true <p>Stereoisomers</p>, <p>Enantiomers</p>, <p>Diastereomers </p>, <p>Stereochemistry</p>, <p>pharmacodynamic phase</p>, <p>conformational, geometric (cis/trans), optical</p>, <p>True</p>, <p>Racemic mixture</p>, <p>diastereomers </p>, <p>Optically active</p>, <p>Levorotatory</p>, <p>Dextrorotatory </p>, <p>Chiral carbons</p>, <p>achiral</p>, <p>meso compound</p>, <p>Advantages of Single-Enantiomer Drugs</p> flashcards
Conformation of Molecules and Stereochemistry

Conformation of Molecules and Stereochemistry

Customize
collection saved
Share
Long Term Learning Spaced Repetition
Add to Long Term Learning Desk
Fast learning Repeat this set of flashcards
Preview Test Spell
Play
Match
Review

  • Stereoisomers

    -possess same molecular formula

    -same atom connectivity

    -nonsuperposable

    -atomic arrangment in space is different

  • Enantiomers

    two mirror-image compounds that are non-superimposable

    -identical physical properties

    -Non-distinguishable with the exception of their ability to rotate plane-polarized light

  • Diastereomers

    -chiral compounds which are not enantiomers

    -not mirror images

  • Stereochemistry

    -the relative 3D spatial arrangement of atoms

    -affects all phase of drug action

    -receptors are "handed," so stereochemistry of ligands can be important

  • pharmacodynamic phase

    Which phase of drug action do stereoisomers have the most affect on?

  • conformational, geometric (cis/trans), optical

    What are the 3 kinds of stereochemical isomerism?

  • True

    Biological activity of an enantiomer can significantly differ from that of its mirror image. T/F?

  • Racemic mixture

    mixture of equal amounts of two stereoisomers of an optically active substance

  • diastereomers

    Cis-trans isomers are not mirror images therefore they are ___

  • Optically active

    any compound that rotates the plane of polarized light

  • Levorotatory

    left (counterclockwise)

  • Dextrorotatory

    right (clockwise)

  • Chiral carbons

    tetrahedral carbons with 4 different attached groups

  • achiral

    when two attached groups on the carbon are the same

  • meso compound

    a molecule with an internal mirror plane of symmetry

  • Advantages of Single-Enantiomer Drugs

    -increased selectivity

    -reduced risk of drug-drug interactions

    -less complex pharmacokinetics

    -may improve therapeutic response of patients