what is the osmolality of the filtrate in the bowman's capsule?
300 mOsm
what is the osmolality of the filtrate as it enters the PCT?
300 mOsm
____________ present in the PCT cells that moves ________ from the _______ back into the ____________ ___________
microvilli
sodium
filtrate
peritubular capillaries
once sodium is reabsorbed, the anion __________ follows along the __________________ gradient
chloride
electrochemical
once salt is reabsorbed, ________ molecules follow along the __________ gradient
water
osmotic
once water is reabsorbed, other solutes like _______ _______ _________, various ions, and _______ in the tubules follow water along the _______________ gradient
lipid soluble substances
urea
concentration
what is the osmolality of the filtrate as it enters the descending limb of the loop of henle?
400 mOsm
what is the descending loop of henle permeable to?
water but not salt
what happens to the osmolality of the filtrate as it travels down the descending limb of the loop of henle?
why?
osmolality of the filtrate increases as water is reabsorbed through passive transport
what is the osmolality of the filtrate as it reaches the end of the descending limb of the loop of henle and begins up the ascending limb?
1200 mOsm
what is the ascending limb of the loop of henle permeable to?
impermeable to water and pumps out salt through active transport
what happens to the osmolality of the filtrate as it travels up toward the DCT?
why?
osmolality of the filtrate decreases as sodium and chloride are pumped out
what is the osmolality once the filtrate reaches the DCT?
100 mOsm
what happens to the osmolality of the filtrate as it travels through the collecting duct if the person has had a lot of water to drink?
decreases to 100 mOsm due to decrease in ADH production and aquaporins in collecting duct
what happens to the osmolality of the filtrate as it travels through the collecting duct if the person is dehydrated
increases from 150 mOsm to 1200 mOsm due to increase in ADH production and aquaporins in collecting duct
______ ______ are capillary branches that supply nephron loops in the ________ region of the kidney, they are highly _______ to ________ and ________
vasa recta
permeable
water
solutes
The _______ _________ preserves the medullary gradient by acting as ___________ _________
Since they are highly permeable to water and solutes they are nearly __________ to the surrounding __________ ______. This allows them to reabsorb ______ and _______ into the general ___________ without undoing the _________ ________ created by the ______________ _________.
vasa recta
countercurrent exchangers
isosmotic
interstitial fluid
water
solutes
circulation
osmotic gradient
juxtamedullary nephrons
what creates the gradient in the renal medulla?
long nephron loops of the juxtamedullary nephrons by acting as countercurrent multipliers
sodium and chloride are actively pumped out into the __________ __________ in the __________ _____ __ ________
interstitial fluid
ascending loop of henle
the deepest region of the renal medulla is ___________ as it has the highest solute concentration
hypertonic
Descending Loop Concentrates Filtrate:
As ________ moves out of the ________ in the ___________ ______ due to ________, the _______ becomes more ______________.
water
filtrate
descending loop
osmosis
filtrate
concentrated
2. Ascending Loop Concentrates Interstitium
The ___________ ____ actively pumps ________ back into the _________ ______ _____, further increasing the ____________ in the ______ regions.
ascending loop
solutes
medullary interstitial fluid
concentration
deeper
Vasa Recta Maintains Gradient
The _______________ flow in the _______ ______ helps to prevent it from washing away the ________ concentrated by the ___________ _____. It loses _____ but picks up some ______, maintaining the overall ________.
countercurrent
vasa recta
solutes
ascending loop
water
solutes
gradient