2022-10-19T18:56:54+03:00[Europe/Moscow] en true <p>Osteogenesis imperfecta </p>, <p>defective synthesis of collagen I alpha chains</p>, <p>Developmental hip dysplasia</p>, <p>scoliosis</p>, <p>b</p>, <p>osteopenia</p>, <p>osteoporosis</p>, <p>osteoporosis</p>, <p>postmenopausal caucasian and asian women</p>, <p>TNF, IL-1, IL-6 cytokines</p>, <p>estrogen replacement therapy, SERMs</p>, <p>testosterone, biphosphonates, calcitonin</p>, <p>biphosphonates</p>, <p>calcitonin</p>, <p>osteomalacia</p>, <p>rickets</p>, <p>Paget disease</p>, <p>first degree family member w disease, paramyxovirus particles in osteoclasts</p>, <p>bisphosphonates and calcitonin</p> flashcards
Ch. 58 Developmental and Metabolic disorders

Ch. 58 Developmental and Metabolic disorders

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  • Osteogenesis imperfecta

    -results in thin poorly developed bones, short limbs, hearing loss due to otoscelrosis, prone to multiple fractures

    -occurrence: 20,000-50,000

  • defective synthesis of collagen I alpha chains

    What is the cause of Osteogenesis imperfecta?

  • Developmental hip dysplasia

    -unstable, subluxated, or complete dislocated

    -occurrence: 1 in 100 have instability; 1 in 1000 have complete dislocation

    -more frequent in girls

  • scoliosis

    -lateral deviation of spine

    -girls are affected most of the time

  • b

    Scoliosis is defined as _________

    a. cryptogenic

    b. idiopathic

    c. agnogenic

  • osteopenia

    -lack of bone mass

    -reduction in bone mass greater than expected

    -includes all metabolic bone diseases

  • osteoporosis

    Which is more debilitating, osteopenia or osteoporosis ?

  • osteoporosis

    -loss of mineralized bone mass causing porosity

    -associated with aging, gender, genetics, activity level, and nutrition

    -susceptible to fractures

  • postmenopausal caucasian and asian women

    Which demographic has the highest rate of osteoperosis?

  • TNF, IL-1, IL-6 cytokines

    Decreased estrogen is associated with increased ___________ that stimulate osteoclast precursors.

  • estrogen replacement therapy, SERMs

    Metabolic treatment for women?

  • testosterone, biphosphonates, calcitonin

    Metabolic treatment for men?

  • biphosphonates

    -analogs of endogenous inorganic pyrophosphates

    -bind to hydroxyapatite to prevent bone reabsorption by inhibiting osteoclast activity

  • calcitonin

    -endogenous peptide that partially inhibits osteoclastic activity

  • osteomalacia

    -softening of bones not involving bone matrix loss

    -inadequate mineralization of bone (adults)

  • rickets

    -failure/delay in calcification of growth plate

    -skeletal pain and deformities, bow legged

  • Paget disease

    -local areas of excessive bone turnover lesions with increased osteoblastic deposition of bone

    -chaotic in fashion; causes bone deformities

    -2nd most common bone disease

  • first degree family member w disease, paramyxovirus particles in osteoclasts

    What are the causes of Paget disease?

  • bisphosphonates and calcitonin

    Treatment for Paget disease?