Hosam Mohamed-
renal corpuscle, renal tubule
What are the components of the nephron?
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bowman's capsule, glomerular capillaries
What are the components of the renal corpuscle?
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a
Which one is responsible for plasma filtration?
a) renal corpuscle
b) glomerular capillaries
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Glomerulus
-a network of capillaries that invaginate into Bowman's capsule
-lined by endothelial cells and supported by a basement membrane
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visceral layer of bowman's capsule
The glomerulus is covered by what?
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high; fenestrated; endothelial
The glomerulus is a ________ pressured, __________ capillary with large holes between the ________ cells.
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lamina rara interna, lamina dense, lamina rara externa
What are the three layers of the basement membrane?
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lamina rara interna
The ______ is fused to the endothelium
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lamina densa
The _______ is located in the middle of the basement membrane
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lamina rara externa
The ________ is fused to the epithelial cell layer
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does not permit filtration of plasma proteins; especially albumin
What is the function of the basement membrane?
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foot processes
Podocytes are attached to the basement membrane via ______
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Filtration slits
-between the foot processes
- range from 25 - 60 nm in diameter
-due to small size, can also act as important barrier to filtration
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negatively charged; glycocalyx
FPs are covered with _________ coat; also known as ________.
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c
What do podocyte foot processes (FPs) contain?
a) tubulin-based cytoskeleton
b) f-actin cytoskeleton
c) actin-based cytoskeleton
d) myosin-based cytoskeleton
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Slit diaphragm
-a group of proteins actively participating in podocyte signaling
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a
What is the best way to describe the Slit diaphragm's structure?
a) multiprotein complex
b) single-protein structure
c) glycoprotein structure
d) none of the above.
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proteinuria
Damage to the slit processes can cause what disease?
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structural support of the capillary loop, barrier against proteins, synthesis & repair of GBM, production of growth factors, immunologic function
What are the 5 major functions of Podocytes?
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traverse gbm against flow of glomerular filtration, maintain healthy endothelium, acts on vegf receptors on glomerular endothelial cells
What are the main functions of Vascular endothelial growth factor (vegf)?
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Platelet-derived growth factors
- critical for the development and migration of mesangial cells into the mesangium.
-
innate immune
Podocytes may be a component of the _________ system.
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d
Podocytes may have a surveillance role for pathogens or abnormal proteins in ________.
a) glomerulus
b) basement membrane
c) lamina externa
d) bowman space
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size selective; charge-dependent
The Glomerular Basement membrane acts as a 3 layer filtration barrier due to it being _________ & __________.
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d
The filtration barrier restricts the passage of _____ & ______.
a) cationic molecules
b) anionic molecules
c) macromolecules
d) b & c
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proximal convoluted tubule
Where does the glomerular capsule direct filtrate towards ?
