Cefepime
What is our only 4th generation Cephalosporin?
Pneumonia caused by ab resistant KES; Complicated UTI caused by Pseudomonas
What is Cefepime used for?
most stable to ceph'ases
What is unique about Cefepime in regard to all other Cephs?
phlebitis, neutropenia
AE associated with cefepime?
ceftaroline fosamil, ceftolozane, zerbaxa
What are our 5th generation Cephalosporins? (3)
ceftolozane + tazobactam
What is the Cephalosporin and B-lactamase inhibitor that make up Zerbaxa?
ceftaroline fosamil
Which 5th gen ceph is a prodrug?
side chain is specially designed to bind MRSA PBP2a
What is special about ceftaroline fosamil's moa?
antibiotic-resistant gm+ & gm-
Ceftaroline Fosamil spectrum?
d
Which species is Ceftaroline fosamil NOT active against?
a) MRSA
b) KES
c) MDR Strep
d) Psuedomonas
KES, pseudomonas, and anaerobes
Zerbaxa is active against what bacteria?
complicated ssi, community-acquired pneumonia
Ceftaroline Fosamil is used to treat ______.
complicated UTI
Zerbaxa is used to treat ________.
c
Which 4th/5th gen is administered via IV only?
a) ceftaroline fosamil
b) cefepime
c) zerbraxa
ceftaroline fosamil
Which 5th Generation Cephalosporin is the only beta lactam active against MRSA?
ceftaroline fosamil
Which 5th Generation Cephalosporin is broad spectrum and has high rates of C. Diff?