press-fit gelcaps
-unique dosage form consisting of a high-gloss gelatin coating that encases a caplet core.
increased amount of polyhydric alcohol
What makes soft gelatin capsules more elastic?
drug migration in shell via partition coefficient
What is a disadvantage associated with Soft Gelatin capsules?
emulsions, aqueous suspensions, high moisture content
What cannot be filled in hard capsules?
more expensive than tabs, rapid release can cause gastric irritation, adhesion to esophagus
What are disadvantages of hard gelatin capsules?
weight uniformity, content uniformity, disintegration test, dissolution test
What are the tests for capsules?
dissolution test
-tests how fast the drug comes out of the capsule
disintegration test
-how quickly does the capsule come apart