Karma Kagyu (Tibetan: ཀརྨ་བཀའ་བརྒྱུད, Wylie: karma bka'-brgyud), or Kamtsang Kagyu (Tibetan: ཀརྨ་ཀཾ་ཚང་, Wylie: kar+ma kaM tshang), is probably the 2nd largest and certainly the most widely practiced lineage within the Kagyu school, one of the four major schools of Tibetan Buddhism.