2023-03-17T04:42:05+03:00[Europe/Moscow] en true <p>vancomycin, telavancin, oritavancin, dalbavancin, bacitracin </p>, <p>streptomycin, gentamicin, tobramycin, kanamycin, amikacin, plazomicin, neomycin, paromycin</p>, <p>polymyxin, colistin, coly-mycin</p>, <p>daptomycin</p>, <p>aminoglycosides, polypeptides, tetracyclines</p>, <p>erythromycin, clarithromycin, azithromycin, telithromycin, fidaxomicin</p>, <p>lincomycin, clindamycin</p>, <p>passes through gm- porin channel, binds to 30s subunit, blocks initiation complex at 50s subunit causing codon misreading and defective proteins to be formed</p>, <p>nephrotoxicity, ototoxic, neurotoxic, teratogenic </p>, <p>tetracycline, doxycycline, minocycline</p>, <p>Tigecycline, Omadacycline, eravacycline, sarecycline </p>, <p>reversible inhibition of protein synthesis; reversibly binds to A-site of 30s subunit</p>, <p>inhibits transglycose reaction; blocks linkage to NAM-NAG</p>, <p>red man syndrome</p>, <p>binds to 50s ribosomal subunit and inhibits bacterial protein synthesis by blocking translocation</p>, <p>aminoglycosides, tetracyclines, </p>, <p>macrolides, lincosamines, pleuromutilins, synercid, oxazolidinones </p>, <p>bind to 50s ribosomal subunit, prevent formation of 70s ribosomal initiation, inhibit translation, inhibit protein synthesis</p>, <p>linezolid, tedizolid</p>, <p>epoxide group binds to isoleucine tRNA ligase; inhibiting protein synthesis</p>, <p>retapamulin, lefamulin</p>, <p>bind to 50s; inhibit peptidyl transferase; inhibit protein synthesis</p>, <p>macrolides, tetracyclines</p>, <p>bacitracin, clindamycin, lincomycin, chloramphenicol, oxazolidinones, glycopeptides, pleuromutilins</p>, <p>aminoglycosides, daptomycin, mupirocin, synercid, lipoglycopeptides</p> flashcards
BMS exam II (Big Picture)

BMS exam II (Big Picture)

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  • vancomycin, telavancin, oritavancin, dalbavancin, bacitracin

    What are our Glycopeptides? (5)

  • streptomycin, gentamicin, tobramycin, kanamycin, amikacin, plazomicin, neomycin, paromycin

    What are our Aminoglycosides? (8)

  • polymyxin, colistin, coly-mycin

    What are our Polypeptide cationic detergents? (3)

  • daptomycin

    What is our lipopetide anionic detergent? (1)

  • aminoglycosides, polypeptides, tetracyclines

    Which classes are active against Gm (-)?

  • erythromycin, clarithromycin, azithromycin, telithromycin, fidaxomicin

    What are our Macrolides? (5)

  • lincomycin, clindamycin

    What are our Lincosamines? (2)

  • passes through gm- porin channel, binds to 30s subunit, blocks initiation complex at 50s subunit causing codon misreading and defective proteins to be formed

    Aminoglycoside MOA?

  • nephrotoxicity, ototoxic, neurotoxic, teratogenic

    Adverse effects associated with Aminoglycosides?

  • tetracycline, doxycycline, minocycline

    What are our 1st generation tetracyclines?

  • Tigecycline, Omadacycline, eravacycline, sarecycline

    What are our 2nd generation tetracyclines?

  • reversible inhibition of protein synthesis; reversibly binds to A-site of 30s subunit

    What is the MOA of tetracyclines?

  • inhibits transglycose reaction; blocks linkage to NAM-NAG

    Glycopeptide MOA?

  • red man syndrome

    What are side effects associated with Glycopeptides?

  • binds to 50s ribosomal subunit and inhibits bacterial protein synthesis by blocking translocation

    Macrolides MOA?

  • aminoglycosides, tetracyclines,

    Which AB bind to 30s?

  • macrolides, lincosamines, pleuromutilins, synercid, oxazolidinones

    Which AB bind to 50s

  • bind to 50s ribosomal subunit, prevent formation of 70s ribosomal initiation, inhibit translation, inhibit protein synthesis

    Oxazolidinones MOA?

  • linezolid, tedizolid

    What are our Oxazolidinones? (2)

  • epoxide group binds to isoleucine tRNA ligase; inhibiting protein synthesis

    Mupirocin MOA?

  • retapamulin, lefamulin

    What are our Pleuromutilins?

  • bind to 50s; inhibit peptidyl transferase; inhibit protein synthesis

    What is the MOA of Chloramphenicol, Macrolides, and Clindamycin?

  • macrolides, tetracyclines

    What are our bacteriostatic agents? (2)

  • bacitracin, clindamycin, lincomycin, chloramphenicol, oxazolidinones, glycopeptides, pleuromutilins

    What are drugs that can either be bacteriostatic or cidal? (7)

  • aminoglycosides, daptomycin, mupirocin, synercid, lipoglycopeptides

    What drugs are strictly cidal? (5)