2023-09-29T03:05:10+03:00[Europe/Moscow] en true <p>1-2 weeks; 4-8 weeks</p>, <p>budesonide </p>, <p>LABA + ICS</p>, <p>add on for step 4 &amp; higher; patients w/ history of exacerbation &gt;=12 yo</p>, <p>preventative treatment prior to exercise or exposure to known allergen </p>, <p>a,c</p>, <p>d</p>, <p>a</p>, <p>c</p>, <p>a,b </p>, <p>take at least 1 hour before or 2 hours after meals </p>, <p>c</p>, <p>adults w/ chronic rhinosinusitis &amp; nasal polyps + ASA sensitivity </p>, <p>moderate to severe </p>, <p>e</p>, <p>epinephrine autoinjector </p>, <p>a</p>, <p>no anaphylaxis after 3&gt;= doses, can recognize &amp; manage rx, use proper inj technique </p>, <p>mepolizumab, reslizumab, benralizumab</p>, <p>moderate-severe asthma in patients 6&gt;= yo w positive skin test or in vitro reactivity to perennial aeroallergen </p>, <p>f</p>, <p>f</p>, <p>Budesonide + albuterol </p>, <p>skin bruising, osteoporosis, cataracts </p>, <p>15% decrease in PEF or FEV1</p>, <p>oxygen, continuous SABA use and inhaled ipatropium, systemic corticosteroids</p>, <p>magnesium sulfate, epinephrine, terbutaline, ketamine, Heliox </p>, <p>&gt;=1 exacerbation in previous year + SABA monotherapy, overuse of SABA (poor), poor adherence, incorrect inhaler technique, low FEV1, smoking, blood eosinophilia, no tools to assess risk </p>, <p>8 puffs; 36 mcg</p>, <p>12 puffs; 54 mcg </p>, <p>LAMAs</p>, <p>blurred vision, urinary retention, dry mouth, constipation</p>, <p>adrenal suppression, Cushing's syndrome, cataracts, impaired immune system</p>, <p>ICS</p>, <p>2 weeks</p>, <p>add-on therapy for asthma not controlled on low-medium dose of ICS; prevention of exercised induced bronchospasm </p> flashcards
Asthma Therapeutics (pt.2)

Asthma Therapeutics (pt.2)

  • 1-2 weeks; 4-8 weeks

    When will patients see initial improvement when starting an ICS?

    When will they see the maximum improvement?

  • budesonide

    ________ is the only FDA approved ICS for children younger than 4 years.

  • LABA + ICS

    Use of _________ combo is NOW recommended to treat acute symptoms or

    exacerbations of asthma.

  • add on for step 4 & higher; patients w/ history of exacerbation >=12 yo

    Spiriva Respimat is considered what type of medication and for who?

  • preventative treatment prior to exercise or exposure to known allergen

    Cromolyn Sodium is used for what?

  • a,c

    Which are used as alternative STEP 2 treatments

    a) methylxanthines

    b) spiriva respimat

    c) cromolyn sodium

    d) trelegy ellipta

  • d

    Which is reserved for step 5 therapy?

    a) methylxanthines

    b) spiriva respimat

    c) cromolyn sodium

    d) trelegy ellipta

  • a

    Which have a narrow therapeutic index?

    a) methylxanthines

    b) spiriva respimat

    c) cromolyn sodium

    d) trelegy ellipta

  • c

    Which is available as a tablet and oral granules?

    a) zafirlukast

    b) Zileuton

    c) Montelukast

  • a,b

    Which inhibits CYP3A4?

    a) zafirlukast

    b) Zileuton

    c) Montelukast

  • take at least 1 hour before or 2 hours after meals

    How does Zafirlukast dosing work?

  • c

    Which has to be taken at night?

    a) zafirlukast

    b) Zileuton

    c) Montelukast

  • adults w/ chronic rhinosinusitis & nasal polyps + ASA sensitivity

    Montelukast is a good option for patients with what condition?

  • moderate to severe

    Immune modulators are for __________ asthma.

  • e

    Which is the ONLY one that won't cause severe allergic reactions?

    a) omalizumab

    b) mepolizumab

    c) reslizumab

    d) benralizumab

    e) dupilumab

    f) tezepelumab

  • epinephrine autoinjector

    Patients who have been prescribed immune modulators require what else

    along with their medication?

  • a

    Which requires initiation in a HC setting ?

    a) omalizumab

    b) mepolizumab

    c) reslizumab

    d) benralizumab

    e) dupilumab

    f) tezepelumab

  • no anaphylaxis after 3>= doses, can recognize & manage rx, use proper inj technique

    What is the criteria for self-administration of Omalizumab? (3)

  • mepolizumab, reslizumab, benralizumab

    Which is for severe eosinophilic asthma? (3)

  • moderate-severe asthma in patients 6>= yo w positive skin test or in vitro reactivity to perennial aeroallergen

    Omalizumab indication?

  • f

    Which is taken once every 4 weeks?

    a) omalizumab

    b) mepolizumab

    c) reslizumab

    d) benralizumab

    e) dupilumab

    f) tezepelumab

  • f

    Which is approved for severe asthma in ages >=12 ?

    a) omalizumab

    b) mepolizumab

    c) reslizumab

    d) benralizumab

    e) dupilumab

    f) tezepelumab

  • Budesonide + albuterol

    What is the preferred asthma treatment in pregnancy?

  • skin bruising, osteoporosis, cataracts

    What AE's can occur in elderly patients when taking asthma medications? (3)

  • 15% decrease in PEF or FEV1

    How is Exercise-Induced Bronchospasm (EIB) diagnosed?

  • oxygen, continuous SABA use and inhaled ipatropium, systemic corticosteroids

    What is the primary treatment for exacerbations? (3)

  • magnesium sulfate, epinephrine, terbutaline, ketamine, Heliox

    What are the adjunctive therapies for exacerbation? (5)

  • >=1 exacerbation in previous year + SABA monotherapy, overuse of SABA (poor), poor adherence, incorrect inhaler technique, low FEV1, smoking, blood eosinophilia, no tools to assess risk

    Risk factors of exacerbations? (8)

  • 8 puffs; 36 mcg

    Max daily dose of MART therapy in ages 4-11?

  • 12 puffs; 54 mcg

    Max daily dose of MART therapy in ages >=12 ?

  • LAMAs

    Use of _____ should be used in caution with African American patients as it

    can increase risk of death.

  • blurred vision, urinary retention, dry mouth, constipation

    AE's of SAMAs? (4)

  • adrenal suppression, Cushing's syndrome, cataracts, impaired immune system

    Long-term AE's of Systemic Corticosteroids? (4)

  • ICS

    _______ are the ONLY therapy that reduces the risk of dying from asthma.

  • 2 weeks

    Budesonide nebules have ampules that should be used within _______ of opening the aluminum package.

  • add-on therapy for asthma not controlled on low-medium dose of ICS; prevention of exercised induced bronchospasm

    LABA indication? (2)