ischemic heart disease (IHD)
-arteries of the heart cannot deliver enough blood to the heart
Coronary artery disease (CAD)
-buildup of plaque inside the coronary arteries; can be obstructive or non-obstructive
peripheral arterial disease (PAD)
-narrowing of the peripheral arteries in legs, stomach, arms, and head
CAD, HF, stroke, HTN
What diseases are considered cardiovascular disease (CVD) ? (4)
STEMI, NSTEMI, UA
What diseases fall under Acute Coronary Syndrome (ACS)? (3)
ACS, hx of MI, stable/unstable angina, coronary stroke, TIA, PAD
What diseases fall under ASCVD? (6)
>=50% of lumen
Obstructive CAD =
atherosclerosis
-inflammatory process characterized by the thickening and hardening of
vessel walls causing the arteries to lose the ability to change lumen size.
smoking, HTN, dyslipidemia
What are the 3 biggest risk factors for CAD/PAD?
a
Injury occurs to the entire myocardial wall in _____.
a) STEMI
b) NSTEMI
c) Unstable Angina
b
Injury is limited to the subendocardial myocardium in ____.
a) STEMI
b) NSTEMI
c) Unstable Angina
c
Ischemia hasn't progressed to the point of necrosis yet.
a) STEMI
b) NSTEMI
c) Unstable Angina
a
This disease state is characterized by ST segment elevation/prolongation.
a) STEMI
b) NSTEMI
c) Unstable Angina
a,b
These disease states are positive for Troponin.
a) STEMI
b) NSTEMI
c) Unstable Angina
c
This disease state has no change in the ST segment.
a) STEMI
b) NSTEMI
c) Unstable Angina
CK-MB, troponin, myoglobin ; useful in confirming diagnosis and estimating infarction size
What enzymes are released from myocardial cells after injury? (3)
What can they tell us?
false; positive test must always correlate w/ patients symptoms
Troponins are always elevated for cardiac reasons. T/F?
chest pain/pressure, pain/tingling in left arm, back pain, jaw pain, shortness of breath, dizzy, nausea, palpitations
What are the major symptoms of a heart attack/ MI? (8)
exertional angina that doesn't change w breathing; not sharp or reproducible; pain may radiate
Signs/ Symptoms of SIHD?
prevent platelet activation & aggregation in arterial blood vessels
What is the purpose of Anti-platelet drugs?
to prevent formation of fibrin clots
What is the purpose of Anticoagulants?
to increase the amount of plasmin & break down clots
What is the purpose of Fibrinolytic drugs?
ASA, P2Y12 inhibitors, abciximab, eptifibatide, triofiban
Which drugs are Anti-Platelets? (5)
Heparin, bilvalirudin, rivaroxaban, dabigatran
Which drugs are Anticoagulants (4 )
alteplase, tenectepalse, reteplase
Which drugs are fibrinolytics? (3)
platelet repulsion, thrombin dilution, endogenous anticoagulants
What are the 3 physiological mechanisms we possess to prevent inappropriate clotting?
anti-thrombin, protein c/s
What are our endogenous anticoagulants?