Antihypertensive agents

Moxonidine (INN) is a new-generation centrally acting antihypertensive drug licensed for the treatment of mild to moderate essential hypertension.

Hydrochlorothiazide (abbreviated HCTZ, HCT, or HZT), is a diuretic medication often used to treat high blood pressure and swelling due to fluid build up.

Tolonidine is an antihypertensive.

Lofexidine (sold under the brand names: BritLofex and Kai Er Ding) is an α2A adrenergic receptor agonist, historically used as an antihypertensive, but more commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal.

Metirosine (INN and BAN; α-Methyltyrosine, Metyrosine USAN, AMPT) is an antihypertensive drug.

Adaprolol is a beta blocker.

Alprenoxime is a beta blocker.

Atiprosin (AY-28,228) is an antihypertensive agent which acts as a selective α1-adrenergic receptor antagonist.

The combination drug olmesartan/amlodipine (trade name Azor in the US) is an oral antihypertensive medication which combines two antihypertensive agents in a film-coated tablet.

Pentolinium is a ganglionic blocking agent which acts as a nicotinic acetylcholine receptor antagonist.

Perindopril/indapamide (marketed as Preterax and Noliprel) is a combination drug used for the treatment of essential hypertension.

Bietaserpine (INN), or 1-diaminoethylreserpine, is a derivative of reserpine used as an antihypertensive agent.

Endralazine is an antihypertensive of the hydrazinophthalazine chemical class.

Guanfacine (brand name Estulic, Tenex and the extended release Intuniv) is a sympatholytic drug used in the treatment of attention deficit hyperactivity disorder (ADHD), anxiety and hypertension (not to be confused with guaifenesin, an expectorant).

Guanoclor is a sympatholytic drug.

Guanadrel is an antihypertensive agent.

Valsartan/sacubitril (brand name Entresto) is a combination drug for use in heart failure developed by Novartis.

Lidanserin (INN; ZK-33,839) is a drug which acts as a combined 5-HT2A and α1-adrenergic receptor antagonist.

Xibenolol is a beta blocker.

Xipranolol is a beta blocker.

Sacubitril (/səˈkjuːbᵻtrɪl/; INN developmental code name AHU-377) is an antihypertensive drug used in combination with valsartan.

Ciclafrine (INN) is a sympathomimetic phenethylamine and antihypertensive which does not appear to have ever been marketed.

Sacubitrilat (INN; or LBQ657) is the active metabolite of the antihypertensive drug sacubitril, which is used in the treatment of heart failure.

Reserpine (also known by trade names Raudixin, Serpalan, Serpasil) is an indole alkaloid, antipsychotic, and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms, although because of the development of better drugs for these purposes and because of its numerous side-effects, it is rarely used today.

Dihydralazine is a drug with antihypertensive properties.

Rescinnamine is an angiotensin-converting enzyme inhibitor used as an antihypertensive drug.

Alfurolol is a beta blocker.

Arnolol is a beta blocker.

Clonidine (trade names Catapres, Kapvay, Nexiclon, Clophelin, and others) is a medication used to treat high blood pressure, attention deficit hyperactivity disorder, anxiety disorders, withdrawal (from either alcohol, opioids, or smoking), migraine, menopausal flushing, diarrhea, and certain pain conditions.

Methyldopa, sold under the brand name Aldomet among others, is a centrally acting antihypertensive agent.

Ajmalicine, also known as δ-yohimbine or raubasine, is an antihypertensive drug used in the treatment of high blood pressure.

Ketanserin (INN, USAN, BAN) (brand name Sufrexal; former code name R41468) is a drug used clinically as an antihypertensive agent and in scientific research to study the serotonin system; specifically, the 5-HT2 receptor family.

Hydralazine (trade name Apresoline) is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles.

Ancarolol is a beta blocker.

Isosorbide dinitrate/hydralazine is a fixed dose combination drug treatment specifically approved by the US FDA to be used to treat African Americans with congestive heart failure.

Debrisoquine is a derivative of guanidine.

Pildralazine (Atensil), also known as propyldazine or propildazine, is an antihypertensive and vasodilator.

Naftopidil (INN, marketed under the brand name Flivas) is a drug used in benign prostatic hypertrophy which acts as a selective α1-adrenergic receptor antagonist or alpha blocker.

Rilmenidine is a prescription medication for the treatment of hypertension.

Methoserpidine is an antihypertensive drug related to reserpine.

Phentolamine (Regitine) is a reversible nonselective α-adrenergic antagonist.

Prazosin, trade names Minipress, Vasoflex, Lentopres and Hypovase, is a sympatholytic drug used to treat high blood pressure, anxiety, and posttraumatic stress disorder (PTSD).

Bucindolol is a non-selective beta blocker with additional weak alpha-blocking properties and some intrinsic sympathomimetic activity.

Butynamine is a tertiary (a highly hindered) aliphatic amine which has antihypertensive effects.

CYT006-AngQb was an investigational vaccine against angiotensin II, designed to lower blood pressure.

Corynanthine, also known as rauhimbine, is an alkaloid found in the Rauwolfia and Pausinystalia (formerly known as Corynanthe) genera of plants.

Cryptenamine (Unitensen) is a mixture of hypotensive alkaloids extracted from Veratrum album.

Deserpidine (INN) is an antihypertensive drug related to reserpine which occurs naturally in Rauvolfia spp.

Hydracarbazine is a pyridazine that has found use as an antihypertensive agent.