2023-11-04T04:10:54+03:00[Europe/Moscow] en true <p>blood loss/hemorrhage, hemolytic anemia, anemia of chronic disease</p>, <p>infection, autoimmune processes, Pens/Cephs, sulfas, thiazides</p>, <p>folate/B12 deficiency, chronic alcohol intake, metformin</p>, <p>iron deficiency </p>, <p>Hb, hematocrit, MCV, MCH, reticulocytes </p>, <p>Mean Corpuscular Hemoglobin (MCH)</p>, <p>a,b</p>, <p>d</p>, <p>b,c</p>, <p>a</p>, <p>80-96</p>, <p>36-45%</p>, <p>12.3-15.3</p>, <p>dizziness/loss of concentration, pale skin, chest pain, SOB, fatigue/weakness, cold intolerance</p>, <p>iron deficiency, decreased erythropoietin, decreased RBC survival</p>, <p>yearly</p>, <p>2 times a year</p>, <p>every 3 months </p>, <p>&gt; 100 fL</p>, <p>0.5-1.5%</p>, <p>30-50%</p>, <p>&gt;500 ng/mL</p>, <p>14-17.5</p>, <p>42-50%</p>, <p>MCV, reticulocyte </p>, <p>assess/correct for any causes of inflammation, correct iron deficiency, replace EPO</p>, <p>TSat &lt;30%; Ferritin &lt;500ng/mL</p>, <p>TSat &lt;10%; Hgb &lt; 8g/dL</p>, <p>IV</p>, <p>1-3 month trial of oral iron for non-HD patients </p>, <p>200 mg/ day; must take with food; titrate dose</p>, <p>&gt;=3-4 months after anemia resolves; allow iron stores to replenish </p>, <p>TSAT &lt;30%; ferritin &lt;500ng/mL</p> flashcards
Anemia of CKD (Therapeutics)

Anemia of CKD (Therapeutics)

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  • blood loss/hemorrhage, hemolytic anemia, anemia of chronic disease

    What are the causes of Normocytic Anemia? (3)

  • infection, autoimmune processes, Pens/Cephs, sulfas, thiazides

    What are the causes of Hemolytic anemia? (5)

  • folate/B12 deficiency, chronic alcohol intake, metformin

    What are the causes of Macrocytic anemia? (3)

  • iron deficiency

    What is the cause of Microcytic anemia?

  • Hb, hematocrit, MCV, MCH, reticulocytes

    Which labs are used to evaluate anemia? (5)

  • Mean Corpuscular Hemoglobin (MCH)

    -average weight of hemoglobin in RBCs

  • a,b

    Which will have a sustained MCV?

    a) hemolytic anemia

    b) anemia of chronic disease

    c) microcytic anemia

    d) macrocytic anemia

  • d

    Which will have an increase in MCV?

    a) hemolytic anemia

    b) anemia of chronic disease

    c) microcytic anemia

    d) macrocytic anemia

  • b,c

    Which will have a decrease in MCV?

    a) hemolytic anemia

    b) anemia of chronic disease

    c) microcytic anemia

    d) macrocytic anemia

  • a

    Which will have an increase in Reticulocyte count?

    a) hemolytic anemia

    b) anemia of chronic disease

    c) microcytic anemia

    d) macrocytic anemia

  • 80-96

    What is the normal range for MCV?

  • 36-45%

    What is the normal range for Hematocrit (Hct)? (females)

  • 12.3-15.3

    What is the normal range for Hgb? (Females)

  • dizziness/loss of concentration, pale skin, chest pain, SOB, fatigue/weakness, cold intolerance

    What are signs/symptoms of Anemia of CKD? (6)

  • iron deficiency, decreased erythropoietin, decreased RBC survival

    What pathological features do we expect in Anemia of CKD? (3)

  • yearly

    How often do we check Hgb in CKD G3?

  • 2 times a year

    How often do we check Hgb in CKD G4-5?

  • every 3 months

    How often do we check Hgb in CKD G5 + Hemodialysis?

  • > 100 fL

    What MCV value indicates macrocytosis?

  • 0.5-1.5%

    What is the normal reticulocyte range?

  • 30-50%

    What is the normal range for Tsat?

  • >500 ng/mL

    What is the normal range for Ferritin?

  • 14-17.5

    What is normal range for Hgb? (Males)

  • 42-50%

    What is the normal range for Hematocrit (Hct)? (males)

  • MCV, reticulocyte

    Which labs may be normal in Anemia? (2)

  • assess/correct for any causes of inflammation, correct iron deficiency, replace EPO

    What is the treatment for Anemia of CKD? (3)

  • TSat <30%; Ferritin <500ng/mL

    When do we initiate Iron supplementation? (2)

  • TSat <10%; Hgb < 8g/dL

    What are the requirements for a patient to be diagnosed as severe anemia?(2)

  • IV

    In patients on hemodialysis, ______ iron supplementation is preferred.

  • 1-3 month trial of oral iron for non-HD patients

    What are KDIGO recommendations for iron supplementation?

  • 200 mg/ day; must take with food; titrate dose

    How do we dose Oral Iron supplements?

  • >=3-4 months after anemia resolves; allow iron stores to replenish

    How long should patients receive Oral Iron supplements?

  • TSAT <30%; ferritin <500ng/mL

    How can we tell a patient hasn't responded to oral iron supplementation?