c
Which aminoglycoside contains a gunanidino group (guanidine)?
a) Gentamicin
b) Tobramycin
c) streptomycin
d) Kanamycin
e)Amikacin
f) Plazomicin
g) Paromycin
h) Neomycin
it is a basic compound; therefore it makes a delocalized cation when protonated; forming low pH solution
What occurs when Streptomycin comes into H2SO4
gentamicin, tobramycin, streptomycin, amikacin
Which aminoglycoside(s) are only available as IV or IM?
kanamycin
Which aminoglycoside(s) are available orally, IM, and IV?
tuberculosis, black plague; gentamicin
Streptomycin & Gentamicin tx?
ototoxicity, rash
What are common SE's associated with streptomycin?
nephrotoxicity, peripheral neuropathy
What are rare SE's associated with streptomycin?
Gentamicin; streptomycin
__________ is more potent and toxic than _________.
gentamicin, tobramycin
Which aminoglycoside(s) are indicated for treating complicated UTI?
b
Which aminoglycoside(s) are used in conjunction with a nebulizer to treat Pseudomonas?
a) Gentamicin
b) Tobramycin
c) streptomycin
d) Kanamycin
e)Amikacin
f) Plazomicin
g) Paromycin
h) Neomycin
C1; 60%
What is the predominant form in the Gentamicin racemic ? What percentage?
kanamycin
Which aminoglycoside(s) are active against Gm (-), but NOT Pseudomonas?
for pre-operative GI sterilization & catherizing topical wounds/burns
Kanamycin tx?
f
Which aminoglycoside(s) is only available in IV form?
a) Gentamicin
b) Tobramycin
c) streptomycin
d) Kanamycin
e)Amikacin
f) Plazomicin
g) Paromycin
h) Neomycin
f
Which aminoglycoside(s) used as a last resort due to limited data?
a) Gentamicin
b) Tobramycin
c) streptomycin
d) Kanamycin
e)Amikacin
f) Plazomicin
g) Paromycin
h) Neomycin
e
Which aminoglycoside(s) is considered semisynthetic?
a) Gentamicin
b) Tobramycin
c) streptomycin
d) Kanamycin
e)Amikacin
amikacin
Which aminoglycoside(s) contains a derivative form from Kanamycin?
resistant Gm-; pseudo & kes
What is the spectrum for Amikacin?
paromycin
Which aminoglycoside has only an oral form?
amebiasis(dysentery), e.coli
Paromycin tx?
neomycin
Which aminoglycoside is a 1st line treatment to metabolic alkalosis caused by bacteria?
h
Which aminoglycoside has OTC options that are ointment & opthalmic based?
a) Gentamicin
b) Tobramycin
c) streptomycin
d) Kanamycin
e)Amikacin
f) Plazomicin
g) Paromycin
h) Neomycin
tab, solution, ointment
What are the dosage forms of Neomycin?
too toxic for internal use
What is a downside to Paromycin?
h
Which aminoglycoside experience significant resistance to Gm- bacteria s?
a) Gentamicin
b) Tobramycin
c) streptomycin
d) Kanamycin
e)Amikacin
f) Plazomicin
g) Paromycin
h) Neomycin
rapid GI absorption, NM blockade
What are the SE's associated with Kanamycin?
calcium gluconate; neostigtme
How do we treat SE's from Kanamycin?
preoperative GI sterilization, catherization, topical wounds/burns; ammonia removal
Neomycin tx?