2023-11-09T02:07:45+03:00[Europe/Moscow] en true <p>hyperkalemia, metabolic acidosis, hyperphosphatemia, pulmonary/peripheral edema</p>, <p>nephron loss, fibrosis, CKD, CVD, death</p>, <p>&lt; 500 mL/day</p>, <p>&lt;50 mL/day</p>, <p>reduction in urine excretion </p>, <p>hypoperfusion of the renal parenchyma; with or without systemic arterial hypotension </p>, <p>Sepsis </p>, <p>prostaglandins </p>, <p>angiotensin </p>, <p>NSAIDs, diuretics </p>, <p>COX; failure to stabilize GFR</p>, <p>renal vasculature damage, glomerular damage, acute tubular necrosis, acute interstitial nephritis </p>, <p>b</p>, <p>d</p>, <p>c</p>, <p>c</p>, <p>a</p>, <p>infections, autoimmune diseases, medications </p>, <p>a</p>, <p>Antibiotics, NSAIDs, PPIs, diuretics, Psych meds </p>, <p>physically impinged urethra </p>, <p>both; significant AKI</p>, <p>diuretics, bactrim, ciprofloxacin, acyclovir </p>, <p>tissue death; obstruction</p>, <p>cisplatin, Aminoglycosides, amphotericin </p>, <p>identify contributing meds, manage fluids, reduce risk of hyperphosphatemia/hyperkalemia </p> flashcards
AKI (Patho & Pharmacology)

AKI (Patho & Pharmacology)

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  • hyperkalemia, metabolic acidosis, hyperphosphatemia, pulmonary/peripheral edema

    What are the short-term consequences to AKI? (4)

  • nephron loss, fibrosis, CKD, CVD, death

    What are the long-term consequences of AKI? (5)

  • < 500 mL/day

    Oliguria =

  • <50 mL/day

    Anuria=

  • reduction in urine excretion

    What is the first indicator of AKI?

  • hypoperfusion of the renal parenchyma; with or without systemic arterial hypotension

    What is the cause of Pre-Renal AKI?

  • Sepsis

    ________ is one of the leading clinical conditions associated with AKI.

  • prostaglandins

    What is the mediator of Afferent Vasodilation?

  • angiotensin

    What is the mediator of Efferent Vasoconstriction?

  • NSAIDs, diuretics

    What medications are involved in Pre-Renal AKI?

  • COX; failure to stabilize GFR

    NSAIDs inhibit _________ synthesis of vasodilatory PG; resulting in ______________.

  • renal vasculature damage, glomerular damage, acute tubular necrosis, acute interstitial nephritis

    What are the categories of Intrinsic AKI? (4)

  • b

    Which Intrinsic AKI is caused by emboli that block the arteries?

    a) Acute Interstitial Nephritis (AIN)

    b) Renal vasculature damage

    c) Acute Tubular Necrosis (ATN)

    d) Glomerular damage

  • d

    Which Intrinsic AKI is caused by circulating immune complexes that

    deposit in the glomeruli?

    a) Acute Interstitial Nephritis (AIN)

    b) Renal vasculature damage

    c) Acute Tubular Necrosis (ATN)

    d) Glomerular damage

  • c

    Which is the most common type of Intrinsic AKI?

    a) Acute Interstitial Nephritis (AIN)

    b) Renal vasculature damage

    c) Acute Tubular Necrosis (ATN)

    d) Glomerular damage

  • c

    Which results from renal ischemia or nephrotoxins?

    a) Acute Interstitial Nephritis (AIN)

    b) Renal vasculature damage

    c) Acute Tubular Necrosis (ATN)

    d) Glomerular damage

  • a

    Which Intrinsic AKI is characterized by inflammation, edema, and

    inflammatory lesions?

    a) Acute Interstitial Nephritis (AIN)

    b) Renal vasculature damage

    c) Acute Tubular Necrosis (ATN)

    d) Glomerular damage

  • infections, autoimmune diseases, medications

    What are the causes of Acute Interstitial Nephritis? (3)

  • a

    Which Intrinsic AKI is the result of an idiosyncratic delayed

    hypersensitivity reaction?

    a) Acute Interstitial Nephritis (AIN)

    b) Renal vasculature damage

    c) Acute Tubular Necrosis (ATN)

    d) Glomerular damage

  • Antibiotics, NSAIDs, PPIs, diuretics, Psych meds

    Which medication classes are implicated in Acute Interstitial Nephritis? (5)

  • physically impinged urethra

    What is the most common cause of bladder outlet obstruction?

  • both; significant AKI

    Obstruction above the bladder must involve ______ kidneys to cause ________.

  • diuretics, bactrim, ciprofloxacin, acyclovir

    Which medications cause accumulations of oxalate crystals? (4)

  • tissue death; obstruction

    Some medications can cause nephrotoxicity which causes _______ and can also lead to ______.

  • cisplatin, Aminoglycosides, amphotericin

    Which nephrotoxic medications can cause obstruction? (3)

  • identify contributing meds, manage fluids, reduce risk of hyperphosphatemia/hyperkalemia

    How do we manage AKI? (3)