2023-08-31T01:15:01+03:00[Europe/Moscow] en true <p>-pril suffix </p>, <p>-sartan suffix </p>, <p>aliskiren </p>, <p>decrease conversion of Ang I to Ang II; prevents bradykinin breakdown </p>, <p>angiotensin II</p>, <p>bradykinin </p>, <p>no reflex tachycardia, enhance diuretic efficacy; less K+ loss</p>, <p>hypotension, renal failure (patients w/ bilateral renal artery stenosis), hyperkalemia, dry cough, angioedema </p>, <p>d,e</p>, <p>risk of fetal hypotension and renal failure; teratogenic </p>, <p>can block bradykinin-induced vasodilation</p>, <p>potassium supplements &amp; potassium diuretics; hyperkalemia </p>, <p>competitively antagonize AngII binding receptors (AT1); no effect on bradykinin</p>, <p>when they can't tolerate an ACEi</p>, <p>ARBs; ACEi</p>, <p>b</p>, <p>competitive inhibitor of renin; decreases water retention and vasoconstriction</p>, <p>stroke, renal complications, hyperkalemia, hypotension</p>, <p>diabetics; adverse cardiovascular events </p> flashcards
ACE inhibitors, ARBs, and Renin inhibitors

ACE inhibitors, ARBs, and Renin inhibitors

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  • -pril suffix

    How can we tell ACE- inhibitors apart?

  • -sartan suffix

    How can we tell Angiotensin II receptor blockers apart?

  • aliskiren

    What is our renin antagonist?

  • decrease conversion of Ang I to Ang II; prevents bradykinin breakdown

    ACE inhibitor MOA?

  • angiotensin II

    -a potent vasoconstrictor and stimulator of aldosterone secretion

  • bradykinin

    - a vasodilator peptide that stimulates NO and prostaglandins

  • no reflex tachycardia, enhance diuretic efficacy; less K+ loss

    What are benefits of ACEi? (2)

  • hypotension, renal failure (patients w/ bilateral renal artery stenosis), hyperkalemia, dry cough, angioedema

    What are AE's of ACEi?

  • d,e

    Increased Bradykinin leads to what AE's of ACEi?

    a) hypotension

    b) renal failure

    c) hyperkalemia

    d) dry cough

    e) angioedema

  • risk of fetal hypotension and renal failure; teratogenic

    Why is pregnancy contraindicated with ACEi?

  • can block bradykinin-induced vasodilation

    Why are NSAIDs contraindicated with ACEi?

  • potassium supplements & potassium diuretics; hyperkalemia

    What must be avoided when using ACEi? Why?

  • competitively antagonize AngII binding receptors (AT1); no effect on bradykinin

    ARBs MOA?

  • when they can't tolerate an ACEi

    When do we start a patient on an ARB?

  • ARBs; ACEi

    _______ have less coughing and edema than ______.

  • b

    Which is more selective?

    a) ACEi

    b) ARBs

  • competitive inhibitor of renin; decreases water retention and vasoconstriction

    Aliskiren MOA?

  • stroke, renal complications, hyperkalemia, hypotension

    Aliskiren AE's? (4)

  • diabetics; adverse cardiovascular events

    Who can not tolerate a combination of Aliskiren + ACEi or ARB? Why?