2022-05-15T10:10:49+03:00[Europe/Moscow] en true <p>which cells detect a decrease in blood glucose concentration</p>, <p>how do alpha cells respond to a decrease in blood glucose concentration</p>, <p>how do beta cells respond to a decrease in blood glucose concentration</p>, <p>STEP 1 ; Detection</p>, <p>STEP 2; decreases</p>, <p>STEP 3 ; Reception</p>, <p>STEP 4 ; Change</p>, <p>STEP 5 ; wake up ady</p>, <p>STEP 6 catalysis by ady</p>, <p>STEP 7 ; cAMP kinase</p>, <p>STEP 8; A Kinase taps P Kinase</p>, <p>STEP 9 ; active P kinase tap GPes</p>, <p>STEP 10 ; GPes instigator</p>, <p>what process takes place when there is a decrease in blood concentration</p>, <p>what is the importance of the enzyme cascade caused by a decrease in BGC</p>, <p>what is the result of glycogenolysis</p> flashcards

A2 Decrease in Blood Glucose Concentration

CIE Syllabus

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  • which cells detect a decrease in blood glucose concentration

    alpha and beta cells of the islets of Langerhans

  • how do alpha cells respond to a decrease in blood glucose concentration

    by secreting glucagon

  • how do beta cells respond to a decrease in blood glucose concentration

    by stopping the secretion of insulin

  • STEP 1 ; Detection

    a decrease in blood glucose concentration is detected by alpha and beta cells of the islets and secrete glucagon and stop secreting insulin

  • STEP 2; decreases

    the decrease in blood insulin concentration reduces the use of glucose by liver and muscle cells

  • STEP 3 ; Reception

    glucagon binds to receptors in the cell surface membrane of liver cells

  • STEP 4 ; Change

    this binding causes a conformational change in the receptor protein that activates a G protein

  • STEP 5 ; wake up ady

    the activated G protein activates the enzyme adenylyl cyclase

  • STEP 6 catalysis by ady

    active adenylyl cyclase catalyses the conversion of ATP to the second messenger cyclic AMP (cAMP)

  • STEP 7 ; cAMP kinase

    cAMP binds to protein kinase A enzymes and activates them

  • STEP 8; A Kinase taps P Kinase

    active protein kinase A enzymes activate phosphorylase kinase enzymes by adding phosphate groups to them

  • STEP 9 ; active P kinase tap GPes

    active phosphorylase kinase enzymes activate glycogen phosphorylase enzymes

  • STEP 10 ; GPes instigator

    active glycogen phosphorylase enzymes catalyse the breakdown of glycogen to glucose

  • what process takes place when there is a decrease in blood concentration

    Glycogenolysis

  • what is the importance of the enzyme cascade caused by a decrease in BGC

    it amplifies the original signal from glucagon

  • what is the result of glycogenolysis

    releasing of extra glucose by the liver to increase the BGC back to normal