llefebvre01-
what are the 3 types of immune deficiencies?
B cells, T cells, severe combined immune deficiency
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what do B cells deficiencies lead to?
decreased circulating immunoglobulins (producers of antibodies), increased susceptibility to infections
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what do T cells deficiencies lead to?
DiGeorge syndrome -> lack/functioning of thymus tissue (where T cells are produced), leads to chronic candidiasis (pathogen infection)
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what do severe combined deficiencies lead to?
basically no immune response, mutations in critical enzymes or antigen receptors MORE HERE
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what are hypersensitivity reactions?
overeating to things that are harmless/beneficial
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what are type I hypersensitivity reactions? (mechanism, allergy, autoimmunity, alloimmunity, rate of development, Ig class, major effector cell, complement system)
IgE-Mediated
Hay fever, bee stings, asthma
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intermediate
IgE
mast cells
No
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what are type II hypersensitivity reactions? (mechanism, allergy, autoimmunity, alloimmunity, rate of development, Ig class, major effector cell, complement system)
Tissue specific
Drug induced hemolysis
hemolytic anemia
hemolytic disease of newborn
intermediate
IgG + IgM
tissue macrophages
frequently
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what are type III hypersensitivity reactions? (mechanism, allergy, autoimmunity, alloimmunity, rate of development, Ig class, major effector cell, complement system)
Immune complex mediated
Gluten allergy (celiac)
systemic lupus, erythematosus
Anaphylaxis to IgA
intermediate
IgG + IgM
neutrophils
yes
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what are type IV hypersensitivity reactions? (mechanism, allergy, autoimmunity, alloimmunity, rate of development, Ig class, major effector cell, complement system)
cell mediated
poison ivy
Hashimoto's disease
graft rejection
delayed
none
lymphocytes + macrophages
no
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explain type I hypersensitivity reactions
allergen presented -> immune system considers it a threat -> starts producing IgE -> IgE binds to mast cells -> field is prepared, no reaction
allergen represented ->
