1. Decreased transport of and use of glucose (insulin brings glucose to the cells, when there's a deficit not as much sugar will be going into the cells).

2. As a result glucose will remain in the blood and thus blood glucose levels rise (hyperglycemia).

3. The excess glucose spills into the urine (glucosuria).

4. Glucose in the urine exerts osmotic pressure (pulls in lots of fluid), resulting in a large volume of urine being excreted (polyuria).

5. Large fluid loss from hyperglycemia pulls water from the cells, resulting in dehydration.

6. Dehydration causes thirst (polydipsia).

7. Lack of nutrients (ex. glucose) entering the cells stimulates appetite (polyphagia).

Review: Pathophysiology, Chp. 16 - The Endocrine System